A pulsed wave excitation system to characterize micron-scale magnetoelastic biosensors

•We develop a pulse wave excitation system which can be used to resonate and measure micron-scale magnetoelastic (ME) biosensors.•We design a low noise signal amplification system for the time-domain resonance signal of ME biosensors.•We investigate the detection of limit on 200μm-long ME biosensors...

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Veröffentlicht in:Sensors and actuators. A. Physical. 2014-01, Vol.205, p.143-149
Hauptverfasser: Xie, Hong, Chai, Yating, Horikawa, Shin, Li, Suiqiong, Chin, Bryan A., Wikle, H. Clyde
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container_title Sensors and actuators. A. Physical.
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creator Xie, Hong
Chai, Yating
Horikawa, Shin
Li, Suiqiong
Chin, Bryan A.
Wikle, H. Clyde
description •We develop a pulse wave excitation system which can be used to resonate and measure micron-scale magnetoelastic (ME) biosensors.•We design a low noise signal amplification system for the time-domain resonance signal of ME biosensors.•We investigate the detection of limit on 200μm-long ME biosensors with the detection system. This paper describes the design of a resonant frequency measurement system based on a pulsed wave excitation technique that can be used to resonate and measure micron-size Magnetoelastic (ME) biosensors. Current measurement techniques can only detect millimeter and above size ME biosensors. By using a specially designed, dedicated coil and low noise cascade amplifier, the system described in this paper is capable of measuring micron-size (ME) biosensors as small as 200μm in length (200×40×15μm). In the system, a square pulse current is applied to an excitation coil to excite the ME sensors, and a pick-up coil senses its mechanical vibration and converts it to an electrical output signal. The output signal is amplified by a signal amplification circuit and the output waveform is shown on an oscilloscope. Based on the acquired damped oscillating signal, the frequency change due to the mass change on the surface of the ME biosensor can be calculated. The impact of signal amplification on the resonant frequency, amplitude, and Q-factor of the resonant frequency peak, has been studied. The average resonant frequency of a 200μm sensor was found to be 10.8283±0.0027MHz. As a proof-in-concept experiment, the detection system was used in combination with JRB7 phage-coated ME biosensors to detect different concentrations of Bacillus anthracis spores. A statistically significant difference for all concentrations of 5×102spore/ml and higher can be reached by the system.
doi_str_mv 10.1016/j.sna.2013.11.003
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Clyde</creator><creatorcontrib>Xie, Hong ; Chai, Yating ; Horikawa, Shin ; Li, Suiqiong ; Chin, Bryan A. ; Wikle, H. Clyde</creatorcontrib><description>•We develop a pulse wave excitation system which can be used to resonate and measure micron-scale magnetoelastic (ME) biosensors.•We design a low noise signal amplification system for the time-domain resonance signal of ME biosensors.•We investigate the detection of limit on 200μm-long ME biosensors with the detection system. This paper describes the design of a resonant frequency measurement system based on a pulsed wave excitation technique that can be used to resonate and measure micron-size Magnetoelastic (ME) biosensors. Current measurement techniques can only detect millimeter and above size ME biosensors. By using a specially designed, dedicated coil and low noise cascade amplifier, the system described in this paper is capable of measuring micron-size (ME) biosensors as small as 200μm in length (200×40×15μm). 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Clyde</creatorcontrib><title>A pulsed wave excitation system to characterize micron-scale magnetoelastic biosensors</title><title>Sensors and actuators. A. Physical.</title><description>•We develop a pulse wave excitation system which can be used to resonate and measure micron-scale magnetoelastic (ME) biosensors.•We design a low noise signal amplification system for the time-domain resonance signal of ME biosensors.•We investigate the detection of limit on 200μm-long ME biosensors with the detection system. This paper describes the design of a resonant frequency measurement system based on a pulsed wave excitation technique that can be used to resonate and measure micron-size Magnetoelastic (ME) biosensors. Current measurement techniques can only detect millimeter and above size ME biosensors. By using a specially designed, dedicated coil and low noise cascade amplifier, the system described in this paper is capable of measuring micron-size (ME) biosensors as small as 200μm in length (200×40×15μm). In the system, a square pulse current is applied to an excitation coil to excite the ME sensors, and a pick-up coil senses its mechanical vibration and converts it to an electrical output signal. The output signal is amplified by a signal amplification circuit and the output waveform is shown on an oscilloscope. Based on the acquired damped oscillating signal, the frequency change due to the mass change on the surface of the ME biosensor can be calculated. The impact of signal amplification on the resonant frequency, amplitude, and Q-factor of the resonant frequency peak, has been studied. The average resonant frequency of a 200μm sensor was found to be 10.8283±0.0027MHz. As a proof-in-concept experiment, the detection system was used in combination with JRB7 phage-coated ME biosensors to detect different concentrations of Bacillus anthracis spores. 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Clyde</creatorcontrib><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Mechanical &amp; Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Sensors and actuators. A. Physical.</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xie, Hong</au><au>Chai, Yating</au><au>Horikawa, Shin</au><au>Li, Suiqiong</au><au>Chin, Bryan A.</au><au>Wikle, H. Clyde</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A pulsed wave excitation system to characterize micron-scale magnetoelastic biosensors</atitle><jtitle>Sensors and actuators. A. Physical.</jtitle><date>2014-01-01</date><risdate>2014</risdate><volume>205</volume><spage>143</spage><epage>149</epage><pages>143-149</pages><issn>0924-4247</issn><eissn>1873-3069</eissn><abstract>•We develop a pulse wave excitation system which can be used to resonate and measure micron-scale magnetoelastic (ME) biosensors.•We design a low noise signal amplification system for the time-domain resonance signal of ME biosensors.•We investigate the detection of limit on 200μm-long ME biosensors with the detection system. This paper describes the design of a resonant frequency measurement system based on a pulsed wave excitation technique that can be used to resonate and measure micron-size Magnetoelastic (ME) biosensors. Current measurement techniques can only detect millimeter and above size ME biosensors. By using a specially designed, dedicated coil and low noise cascade amplifier, the system described in this paper is capable of measuring micron-size (ME) biosensors as small as 200μm in length (200×40×15μm). In the system, a square pulse current is applied to an excitation coil to excite the ME sensors, and a pick-up coil senses its mechanical vibration and converts it to an electrical output signal. The output signal is amplified by a signal amplification circuit and the output waveform is shown on an oscilloscope. Based on the acquired damped oscillating signal, the frequency change due to the mass change on the surface of the ME biosensor can be calculated. The impact of signal amplification on the resonant frequency, amplitude, and Q-factor of the resonant frequency peak, has been studied. The average resonant frequency of a 200μm sensor was found to be 10.8283±0.0027MHz. As a proof-in-concept experiment, the detection system was used in combination with JRB7 phage-coated ME biosensors to detect different concentrations of Bacillus anthracis spores. A statistically significant difference for all concentrations of 5×102spore/ml and higher can be reached by the system.</abstract><pub>Elsevier B.V</pub><doi>10.1016/j.sna.2013.11.003</doi><tpages>7</tpages></addata></record>
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source ScienceDirect Journals (5 years ago - present)
subjects Amplification
Bacillus anthracis
Biosensors
Cascade amplifier
Coiling
Excitation
Micron-size magnetoelastic biosensor
Pulse wave excitation technique
Resonant frequencies
Sensors
Spores
Wave excitation
title A pulsed wave excitation system to characterize micron-scale magnetoelastic biosensors
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