One-step synthesis of an organic-inorganic hybrid boronate affinity monolithic column with synergistic co-monomers

An organic-inorganic hybrid and synergistic boronate affinity (BA) monolithic column was synthesized by a novel "one-step" approach. We report on the synthesis of a unique organic-inorganic hybrid affinity monolith by using TEOS, the organic silane, N-(β-aminoethyl)-γ-aminopropyltriethoxys...

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Veröffentlicht in:	Analyst (London) 2013-09, Vol.138 (17), p.4752-4755
Hauptverfasser:	Yang, Qin, Huang, Dihui, Jin, Shanxia, Zhou, Hailong, Zhou, Ping
Format:	Artikel
Sprache:	eng
Schlagworte:	Affinity Azobisisobutyronitrile Biomolecules Boronic Acids - chemical synthesis Boronic Acids - chemistry Chemistry Techniques, Synthetic Chromatography, Liquid - methods Monomers Recognition Silanes Silanes - chemistry Synthesis
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container_title	Analyst (London)
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creator	Yang, Qin Huang, Dihui Jin, Shanxia Zhou, Hailong Zhou, Ping
description	An organic-inorganic hybrid and synergistic boronate affinity (BA) monolithic column was synthesized by a novel "one-step" approach. We report on the synthesis of a unique organic-inorganic hybrid affinity monolith by using TEOS, the organic silane, N-(β-aminoethyl)-γ-aminopropyltriethoxysilane (AEAPTES) and γ-MAPS as the co-precursors, 4-vinylphenylboronic acid as the functionalized monomer, and azobisisobutyronitrile (AIBN) as the initiator. Due to the presence of amino groups in the AEAPTES molecule, the prepared monolith exhibits several attractive properties. The monolith will be more hydrophilic and can bind with cis-diol compounds at neutral pH by a mechanism of intermolecular B-N coordination. The resulting hybrid boronate affinity monoliths have potential applications in specific recognition and enrichment of cis-diol biomolecules under neutral conditions.
doi_str_mv	10.1039/c3an00847a
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source	MEDLINE; Royal Society of Chemistry Journals Archive (1841-2007); Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection
subjects	Affinity Azobisisobutyronitrile Biomolecules Boronic Acids - chemical synthesis Boronic Acids - chemistry Chemistry Techniques, Synthetic Chromatography, Liquid - methods Monomers Recognition Silanes Silanes - chemistry Synthesis
title	One-step synthesis of an organic-inorganic hybrid boronate affinity monolithic column with synergistic co-monomers
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