Durability evaluation of biopolymer coating on titanium alloy substrate
For this study, a commercially available phosphorylcholine (PC) polymer was applied to Ti6Al4V ELI. A multivariate approach to design a statistically significant array of experiments was employed to evaluate and estimate optimization of PC-immobilization process factors. The seven process factors an...
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| Veröffentlicht in: | Journal of the mechanical behavior of biomedical materials 2014-07, Vol.35, p.9-17 |
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| creator | Ryan Stanfield, J. Bamberg, Stacy |
| description | For this study, a commercially available phosphorylcholine (PC) polymer was applied to Ti6Al4V ELI. A multivariate approach to design a statistically significant array of experiments was employed to evaluate and estimate optimization of PC-immobilization process factors. The seven process factors analyzed were (1) power level for RFGD plasma treatment, (2) duration of plasma treatment, (3) concentration of PC solution used to coat samples, (4) rate at which samples were dipped in/out of the solution, (5) temperature for curing, (6) relative humidity level during curing, and (7) duration of curing. Imaging and analysis of the coating were done via fluorescence microscopy (FM), confirming the uniform coverage of PC polymer on titanium substrate. The process factors were evaluated by three measured responses: initial thickness, coating durability and degree of cross-linked coating, which were assessed by FM, a spray test and extraction in IPA, respectively. Variations in PC solution concentration showed no impact on fouling resistance of the resultant coating. It was hypothesized that the PC-application process factors could be optimized to yield favorable outcomes in durability and degree of cross-linked coating responses. The resulting statistical model indicates that PC solution concentration, dip rate, and cure temperature are the three greatest singular effects on both durability and degree of cross-linking. In addition, plasma treatment of the substrate with O2 was effective in enhancing the degree of cross-linking of the polymer surface.
[Display omitted]
•Process factors were analyzed to optimize durability of a biomimetic coating.•Fluorescence intensity is used for a novel thickness measurement technique.•Adhesion and durability are quantified by an erosion-simulation spray test method.•Solution concentration, dip rate, and temperature are the chief impact factors. |
| doi_str_mv | 10.1016/j.jmbbm.2014.03.003 |
| format | Article |
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[Display omitted]
•Process factors were analyzed to optimize durability of a biomimetic coating.•Fluorescence intensity is used for a novel thickness measurement technique.•Adhesion and durability are quantified by an erosion-simulation spray test method.•Solution concentration, dip rate, and temperature are the chief impact factors.</description><identifier>ISSN: 1751-6161</identifier><identifier>EISSN: 1878-0180</identifier><identifier>DOI: 10.1016/j.jmbbm.2014.03.003</identifier><identifier>PMID: 24727572</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Adsorption ; Biopolymers - chemistry ; Blood compatibility ; Coated Materials, Biocompatible - chemistry ; Coating ; Cross-Linking Reagents - chemistry ; Crosslinking ; Curing ; Durability ; Implantable medical devices ; Materials Testing ; Mathematical models ; Microscopy, Fluorescence ; Models, Statistical ; Oxygen - chemistry ; Phospholipid polymer ; Phosphorylcholine - chemistry ; Polycarbonates ; Polyethylene Terephthalates - chemistry ; Polymers - chemistry ; Statistical analysis ; Surface Properties ; Surgical implants ; Temperature ; Time Factors ; Titanium - chemistry ; Titanium alloy ; Titanium base alloys</subject><ispartof>Journal of the mechanical behavior of biomedical materials, 2014-07, Vol.35, p.9-17</ispartof><rights>2014 Elsevier Ltd</rights><rights>Copyright © 2014 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c392t-47fc85ec5fa60bc5c5de4a5b1916ec9a9d7b87e9848e5451950323ad263b90b53</citedby><cites>FETCH-LOGICAL-c392t-47fc85ec5fa60bc5c5de4a5b1916ec9a9d7b87e9848e5451950323ad263b90b53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jmbbm.2014.03.003$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,782,786,3552,27931,27932,46002</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24727572$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ryan Stanfield, J.</creatorcontrib><creatorcontrib>Bamberg, Stacy</creatorcontrib><title>Durability evaluation of biopolymer coating on titanium alloy substrate</title><title>Journal of the mechanical behavior of biomedical materials</title><addtitle>J Mech Behav Biomed Mater</addtitle><description>For this study, a commercially available phosphorylcholine (PC) polymer was applied to Ti6Al4V ELI. A multivariate approach to design a statistically significant array of experiments was employed to evaluate and estimate optimization of PC-immobilization process factors. The seven process factors analyzed were (1) power level for RFGD plasma treatment, (2) duration of plasma treatment, (3) concentration of PC solution used to coat samples, (4) rate at which samples were dipped in/out of the solution, (5) temperature for curing, (6) relative humidity level during curing, and (7) duration of curing. Imaging and analysis of the coating were done via fluorescence microscopy (FM), confirming the uniform coverage of PC polymer on titanium substrate. The process factors were evaluated by three measured responses: initial thickness, coating durability and degree of cross-linked coating, which were assessed by FM, a spray test and extraction in IPA, respectively. Variations in PC solution concentration showed no impact on fouling resistance of the resultant coating. It was hypothesized that the PC-application process factors could be optimized to yield favorable outcomes in durability and degree of cross-linked coating responses. The resulting statistical model indicates that PC solution concentration, dip rate, and cure temperature are the three greatest singular effects on both durability and degree of cross-linking. In addition, plasma treatment of the substrate with O2 was effective in enhancing the degree of cross-linking of the polymer surface.
[Display omitted]
•Process factors were analyzed to optimize durability of a biomimetic coating.•Fluorescence intensity is used for a novel thickness measurement technique.•Adhesion and durability are quantified by an erosion-simulation spray test method.•Solution concentration, dip rate, and temperature are the chief impact factors.</description><subject>Adsorption</subject><subject>Biopolymers - chemistry</subject><subject>Blood compatibility</subject><subject>Coated Materials, Biocompatible - chemistry</subject><subject>Coating</subject><subject>Cross-Linking Reagents - chemistry</subject><subject>Crosslinking</subject><subject>Curing</subject><subject>Durability</subject><subject>Implantable medical devices</subject><subject>Materials Testing</subject><subject>Mathematical models</subject><subject>Microscopy, Fluorescence</subject><subject>Models, Statistical</subject><subject>Oxygen - chemistry</subject><subject>Phospholipid polymer</subject><subject>Phosphorylcholine - chemistry</subject><subject>Polycarbonates</subject><subject>Polyethylene Terephthalates - chemistry</subject><subject>Polymers - chemistry</subject><subject>Statistical analysis</subject><subject>Surface Properties</subject><subject>Surgical implants</subject><subject>Temperature</subject><subject>Time Factors</subject><subject>Titanium - chemistry</subject><subject>Titanium alloy</subject><subject>Titanium base alloys</subject><issn>1751-6161</issn><issn>1878-0180</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1v1DAQhi1ERT_gFyChHLkkjO3468ABtaUgVeoFzpbtTJBXSbzYTqX992S7pUc4zWjmmXmlh5D3FDoKVH7adbvZ-7ljQPsOeAfAX5ELqpVugWp4vfVK0FZSSc_JZSk7AAmg9RtyznrFlFDsgtzdrNn5OMV6aPDRTaurMS1NGhsf0z5NhxlzE9I2XX4126LG6pa4zo2bpnRoyupLza7iW3I2uqngu-d6RX5-vf1x_a29f7j7fv3lvg3csNr2agxaYBCjk-CDCGLA3glPDZUYjDOD8lqh0b1G0QtqBHDG3cAk9wa84Ffk4-nvPqffK5Zq51gCTpNbMK3FUqmoML2R6v-oYExqYPSI8hMaciol42j3Oc4uHywFe5Rtd_ZJtj3KtsDtJnu7-vAcsPoZh5ebv3Y34PMJwM3IY8RsS4i4BBxixlDtkOI_A_4Al_2RIg</recordid><startdate>20140701</startdate><enddate>20140701</enddate><creator>Ryan Stanfield, J.</creator><creator>Bamberg, Stacy</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7SR</scope><scope>7TB</scope><scope>8BQ</scope><scope>8FD</scope><scope>FR3</scope><scope>JG9</scope></search><sort><creationdate>20140701</creationdate><title>Durability evaluation of biopolymer coating on titanium alloy substrate</title><author>Ryan Stanfield, J. ; Bamberg, Stacy</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c392t-47fc85ec5fa60bc5c5de4a5b1916ec9a9d7b87e9848e5451950323ad263b90b53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adsorption</topic><topic>Biopolymers - chemistry</topic><topic>Blood compatibility</topic><topic>Coated Materials, Biocompatible - chemistry</topic><topic>Coating</topic><topic>Cross-Linking Reagents - chemistry</topic><topic>Crosslinking</topic><topic>Curing</topic><topic>Durability</topic><topic>Implantable medical devices</topic><topic>Materials Testing</topic><topic>Mathematical models</topic><topic>Microscopy, Fluorescence</topic><topic>Models, Statistical</topic><topic>Oxygen - chemistry</topic><topic>Phospholipid polymer</topic><topic>Phosphorylcholine - chemistry</topic><topic>Polycarbonates</topic><topic>Polyethylene Terephthalates - chemistry</topic><topic>Polymers - chemistry</topic><topic>Statistical analysis</topic><topic>Surface Properties</topic><topic>Surgical implants</topic><topic>Temperature</topic><topic>Time Factors</topic><topic>Titanium - chemistry</topic><topic>Titanium alloy</topic><topic>Titanium base alloys</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ryan Stanfield, J.</creatorcontrib><creatorcontrib>Bamberg, Stacy</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Engineered Materials Abstracts</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Materials Research Database</collection><jtitle>Journal of the mechanical behavior of biomedical materials</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ryan Stanfield, J.</au><au>Bamberg, Stacy</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Durability evaluation of biopolymer coating on titanium alloy substrate</atitle><jtitle>Journal of the mechanical behavior of biomedical materials</jtitle><addtitle>J Mech Behav Biomed Mater</addtitle><date>2014-07-01</date><risdate>2014</risdate><volume>35</volume><spage>9</spage><epage>17</epage><pages>9-17</pages><issn>1751-6161</issn><eissn>1878-0180</eissn><abstract>For this study, a commercially available phosphorylcholine (PC) polymer was applied to Ti6Al4V ELI. A multivariate approach to design a statistically significant array of experiments was employed to evaluate and estimate optimization of PC-immobilization process factors. The seven process factors analyzed were (1) power level for RFGD plasma treatment, (2) duration of plasma treatment, (3) concentration of PC solution used to coat samples, (4) rate at which samples were dipped in/out of the solution, (5) temperature for curing, (6) relative humidity level during curing, and (7) duration of curing. Imaging and analysis of the coating were done via fluorescence microscopy (FM), confirming the uniform coverage of PC polymer on titanium substrate. The process factors were evaluated by three measured responses: initial thickness, coating durability and degree of cross-linked coating, which were assessed by FM, a spray test and extraction in IPA, respectively. Variations in PC solution concentration showed no impact on fouling resistance of the resultant coating. It was hypothesized that the PC-application process factors could be optimized to yield favorable outcomes in durability and degree of cross-linked coating responses. The resulting statistical model indicates that PC solution concentration, dip rate, and cure temperature are the three greatest singular effects on both durability and degree of cross-linking. In addition, plasma treatment of the substrate with O2 was effective in enhancing the degree of cross-linking of the polymer surface.
[Display omitted]
•Process factors were analyzed to optimize durability of a biomimetic coating.•Fluorescence intensity is used for a novel thickness measurement technique.•Adhesion and durability are quantified by an erosion-simulation spray test method.•Solution concentration, dip rate, and temperature are the chief impact factors.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>24727572</pmid><doi>10.1016/j.jmbbm.2014.03.003</doi><tpages>9</tpages></addata></record> |
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| subjects | Adsorption Biopolymers - chemistry Blood compatibility Coated Materials, Biocompatible - chemistry Coating Cross-Linking Reagents - chemistry Crosslinking Curing Durability Implantable medical devices Materials Testing Mathematical models Microscopy, Fluorescence Models, Statistical Oxygen - chemistry Phospholipid polymer Phosphorylcholine - chemistry Polycarbonates Polyethylene Terephthalates - chemistry Polymers - chemistry Statistical analysis Surface Properties Surgical implants Temperature Time Factors Titanium - chemistry Titanium alloy Titanium base alloys |
| title | Durability evaluation of biopolymer coating on titanium alloy substrate |
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