On the structural organization of the intracellular domains of CFTR

The cystic fibrosis transmembrane conductance regulator (CFTR) is a multidomain membrane protein forming an anion selective channel. Mutations in the gene encoding CFTR cause cystic fibrosis (CF). The intracellular side of CFTR constitutes about 80% of the total mass of the protein. This region incl...

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Veröffentlicht in:	The international journal of biochemistry & cell biology 2014-07, Vol.52, p.7-14
1. Verfasser:	Moran, Oscar
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry Biology CFTR Channels Cystic fibrosis Cystic Fibrosis - genetics Cystic Fibrosis - metabolism Cystic Fibrosis Transmembrane Conductance Regulator - chemistry Cystic Fibrosis Transmembrane Conductance Regulator - genetics Cystic Fibrosis Transmembrane Conductance Regulator - metabolism Encoding Humans Models, Molecular Molecular structure NBD Phosphorylation Physiology Protein Binding Protein Structure, Tertiary Proteins Regulatory domain Structure
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