Nanoprecipitation and the “Ouzo effect”: Application to drug delivery devices
Biodegradable nanocarriers such as lipid- or polymer-based nanoparticles can be designed to improve the efficacy and reduce the toxic side effects of drugs. Under appropriate conditions, nanoprecipitation of a hydrophobic compound solution in a non-solvent can generate a dispersion of nanoparticles...
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| Veröffentlicht in: | Advanced drug delivery reviews 2014-05, Vol.71, p.86-97 |
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| creator | Lepeltier, Elise Bourgaux, Claudie Couvreur, Patrick |
| description | Biodegradable nanocarriers such as lipid- or polymer-based nanoparticles can be designed to improve the efficacy and reduce the toxic side effects of drugs. Under appropriate conditions, nanoprecipitation of a hydrophobic compound solution in a non-solvent can generate a dispersion of nanoparticles with a narrow distribution of sizes without the use of surfactant (“Ouzo” effect). The aim of this review is to present the main parameters controlling the nucleation and growth of aggregates in a supersaturated solution and the characteristics of the obtained nanoparticles. The importance of the kinetics of mixing of the solution containing the hydrophobic compound and the non-solvent is highlighted. Illustrative examples of polymeric nanoparticles for drug delivery or terpenoid-based nanoprodrugs obtained by nanoprecipitation are reported.
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| doi_str_mv | 10.1016/j.addr.2013.12.009 |
| format | Article |
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[Display omitted]</description><subject>Biodegradability</subject><subject>Chemical Precipitation</subject><subject>Chemistry, Pharmaceutical</subject><subject>Dispersions</subject><subject>Drug Carriers - chemistry</subject><subject>Drug Delivery Systems</subject><subject>Drug Design</subject><subject>Effectiveness</subject><subject>Humans</subject><subject>Hydrophobic and Hydrophilic Interactions</subject><subject>Lipids - chemistry</subject><subject>Nanoparticles</subject><subject>Nanoprecipitation</subject><subject>Nanostructure</subject><subject>Nucleation</subject><subject>Nucleation and growth</subject><subject>Ouzo effect</subject><subject>Particle Size</subject><subject>Polymers - chemistry</subject><subject>Side effects</subject><subject>Solvents - chemistry</subject><subject>Squalenoylation</subject><subject>Terpenoid prodrug</subject><issn>0169-409X</issn><issn>1872-8294</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc1O3DAQgK2qVdlSXqCHKsdektrj-CcVF4SgrYRAlVqJm-W1x61X2STYyUpw4kHoy_EkZLXAseU0c_jmO8xHyAdGK0aZ_LyqrPepAsp4xaCitHlFFkwrKDU09WuymKGmrGlzuUfe5byilIGS9C3Zg5rrmitYkB_ntuuHhC4OcbRj7LvCdr4Y_2Bxf3t3Md30BYaAbry__fulOBqGNrodNvaFT9PvwmMbN5iu52UTHeb35E2wbcaDx7lPfp2e_Dz-Vp5dfP1-fHRWulrrsXQehArcWcoV0wii8aFWLCBTMgSxtNZxajlqJyQKwZYKvPLSe884pdLxffJp5x1SfzVhHs06Zodtazvsp2yYVEw0THP4PypqkELyhr4EpQAN6K0VdqhLfc4JgxlSXNt0bRg120BmZbaBzDaQYWDmQPPRx0f_tFyjfz55KjIDhzsA599tIiaTXcTOoY9zpdH4Pv7L_wDiV6Lp</recordid><startdate>20140501</startdate><enddate>20140501</enddate><creator>Lepeltier, Elise</creator><creator>Bourgaux, Claudie</creator><creator>Couvreur, Patrick</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope><scope>7TB</scope><scope>7U5</scope><scope>L7M</scope></search><sort><creationdate>20140501</creationdate><title>Nanoprecipitation and the “Ouzo effect”: Application to drug delivery devices</title><author>Lepeltier, Elise ; 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| identifier | ISSN: 0169-409X |
| ispartof | Advanced drug delivery reviews, 2014-05, Vol.71, p.86-97 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Biodegradability Chemical Precipitation Chemistry, Pharmaceutical Dispersions Drug Carriers - chemistry Drug Delivery Systems Drug Design Effectiveness Humans Hydrophobic and Hydrophilic Interactions Lipids - chemistry Nanoparticles Nanoprecipitation Nanostructure Nucleation Nucleation and growth Ouzo effect Particle Size Polymers - chemistry Side effects Solvents - chemistry Squalenoylation Terpenoid prodrug |
| title | Nanoprecipitation and the “Ouzo effect”: Application to drug delivery devices |
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