Factorial design as tool in chitosan nanoparticles development by ionic gelation technique
•This work shows how to obtain chitosan nanoparticles with properties desired.•The formulation was optimized using a 23 factorial design.•Nanoparticles were obtained with size
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| Veröffentlicht in: | Colloids and surfaces. A, Physicochemical and engineering aspects Physicochemical and engineering aspects, 2014-03, Vol.445, p.34-39 |
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| container_title | Colloids and surfaces. A, Physicochemical and engineering aspects |
| container_volume | 445 |
| creator | de Pinho Neves, Andréia Lange Milioli, Camila Cardoso Müller, Leidiani Riella, Humberto Gracher Kuhnen, Nivaldo Cabral Stulzer, Hellen Karine |
| description | •This work shows how to obtain chitosan nanoparticles with properties desired.•The formulation was optimized using a 23 factorial design.•Nanoparticles were obtained with size |
| doi_str_mv | 10.1016/j.colsurfa.2013.12.058 |
| format | Article |
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Since there are different kinds of chitosan, obtained from different sources of chitin and routes, it is very important to study which are the best conditions in order to obtain nanoparticles with desired size and superficial charge. The aim of this paper was to demonstrate to the scientific community how to obtain chitosan nanoparticles (nanoCTS) with these properties. Ionic gelation technique was applied to form nanoparticles through linkages between tripolyphosphate (TPP) and chitosan (CTS). The formulation was optimized using a 23 factorial design to analyze the effect of the pH, CTS:TPP ratio and acetic acid concentration in size and charge of the particles. The best formulation was characterized by FTIR, TGA, EDX and TEM analysis. The formation of nanoCTS depended mainly on ratio of CTS:TPP. Nanoparticles were obtained with excellent conditions for the application in pharmaceutical studies: average diameter of 76.2nm and zeta potential of 32.6mV.</description><identifier>ISSN: 0927-7757</identifier><identifier>EISSN: 1873-4359</identifier><identifier>DOI: 10.1016/j.colsurfa.2013.12.058</identifier><language>eng</language><publisher>Elsevier B.V</publisher><subject>Charge ; Chitosan ; Experimental design ; Factorial design ; Formulations ; Gelation ; Ionic gelation ; Nanoparticles ; Nanostructure ; Tripolyphosphate ; Zeta potential</subject><ispartof>Colloids and surfaces. A, Physicochemical and engineering aspects, 2014-03, Vol.445, p.34-39</ispartof><rights>2014 Elsevier B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c345t-d9e66cc985044da806f64f5b7343324996ad088d60043c3fb4b4114a53b093b33</citedby><cites>FETCH-LOGICAL-c345t-d9e66cc985044da806f64f5b7343324996ad088d60043c3fb4b4114a53b093b33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.colsurfa.2013.12.058$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000</link.rule.ids></links><search><creatorcontrib>de Pinho Neves, Andréia Lange</creatorcontrib><creatorcontrib>Milioli, Camila Cardoso</creatorcontrib><creatorcontrib>Müller, Leidiani</creatorcontrib><creatorcontrib>Riella, Humberto Gracher</creatorcontrib><creatorcontrib>Kuhnen, Nivaldo Cabral</creatorcontrib><creatorcontrib>Stulzer, Hellen Karine</creatorcontrib><title>Factorial design as tool in chitosan nanoparticles development by ionic gelation technique</title><title>Colloids and surfaces. A, Physicochemical and engineering aspects</title><description>•This work shows how to obtain chitosan nanoparticles with properties desired.•The formulation was optimized using a 23 factorial design.•Nanoparticles were obtained with size <90nm.•Nanoparticles were characterized by FTIR, TGA, EDX and TEM analysis.•Sonication is an important step, otherwise, the nanoparticles agglomerate again.
Since there are different kinds of chitosan, obtained from different sources of chitin and routes, it is very important to study which are the best conditions in order to obtain nanoparticles with desired size and superficial charge. The aim of this paper was to demonstrate to the scientific community how to obtain chitosan nanoparticles (nanoCTS) with these properties. Ionic gelation technique was applied to form nanoparticles through linkages between tripolyphosphate (TPP) and chitosan (CTS). The formulation was optimized using a 23 factorial design to analyze the effect of the pH, CTS:TPP ratio and acetic acid concentration in size and charge of the particles. The best formulation was characterized by FTIR, TGA, EDX and TEM analysis. The formation of nanoCTS depended mainly on ratio of CTS:TPP. Nanoparticles were obtained with excellent conditions for the application in pharmaceutical studies: average diameter of 76.2nm and zeta potential of 32.6mV.</description><subject>Charge</subject><subject>Chitosan</subject><subject>Experimental design</subject><subject>Factorial design</subject><subject>Formulations</subject><subject>Gelation</subject><subject>Ionic gelation</subject><subject>Nanoparticles</subject><subject>Nanostructure</subject><subject>Tripolyphosphate</subject><subject>Zeta potential</subject><issn>0927-7757</issn><issn>1873-4359</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><recordid>eNqFkDtPAzEQhC0EEuHxF5BLmjvs8-uuAyFeUiQaaGgsn28vceTYwXYi5d9zUaCm2i1mZnc-hG4oqSmh8m5V2-jzNo2mbghlNW1qItoTNKOtYhVnojtFM9I1qlJKqHN0kfOKEMKF6mbo69nYEpMzHg-Q3SJgk3GJ0WMXsF26ErMJOJgQNyYVZz3kSbgDHzdrCAX3e-xicBYvwJsyrbiAXQb3vYUrdDYan-H6d16iz-enj8fXav7-8vb4MK8s46JUQwdSWtu1gnA-mJbIUfJR9IpxxhreddIMpG0HOb3MLBt73nNKuRGsJx3rGbtEt8fcTYrT2Vz02mUL3psAcZs1lYoKpSjnk1QepTbFnBOMepPc2qS9pkQfYOqV_oOpDzA1bfQEczLeH40wFdk5SDpbB8HC4BLYoofo_ov4ATCRgeM</recordid><startdate>20140320</startdate><enddate>20140320</enddate><creator>de Pinho Neves, Andréia Lange</creator><creator>Milioli, Camila Cardoso</creator><creator>Müller, Leidiani</creator><creator>Riella, Humberto Gracher</creator><creator>Kuhnen, Nivaldo Cabral</creator><creator>Stulzer, Hellen Karine</creator><general>Elsevier B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7U5</scope><scope>8FD</scope><scope>L7M</scope></search><sort><creationdate>20140320</creationdate><title>Factorial design as tool in chitosan nanoparticles development by ionic gelation technique</title><author>de Pinho Neves, Andréia Lange ; Milioli, Camila Cardoso ; Müller, Leidiani ; Riella, Humberto Gracher ; Kuhnen, Nivaldo Cabral ; Stulzer, Hellen Karine</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c345t-d9e66cc985044da806f64f5b7343324996ad088d60043c3fb4b4114a53b093b33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Charge</topic><topic>Chitosan</topic><topic>Experimental design</topic><topic>Factorial design</topic><topic>Formulations</topic><topic>Gelation</topic><topic>Ionic gelation</topic><topic>Nanoparticles</topic><topic>Nanostructure</topic><topic>Tripolyphosphate</topic><topic>Zeta potential</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>de Pinho Neves, Andréia Lange</creatorcontrib><creatorcontrib>Milioli, Camila Cardoso</creatorcontrib><creatorcontrib>Müller, Leidiani</creatorcontrib><creatorcontrib>Riella, Humberto Gracher</creatorcontrib><creatorcontrib>Kuhnen, Nivaldo Cabral</creatorcontrib><creatorcontrib>Stulzer, Hellen Karine</creatorcontrib><collection>CrossRef</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Technology Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Colloids and surfaces. A, Physicochemical and engineering aspects</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>de Pinho Neves, Andréia Lange</au><au>Milioli, Camila Cardoso</au><au>Müller, Leidiani</au><au>Riella, Humberto Gracher</au><au>Kuhnen, Nivaldo Cabral</au><au>Stulzer, Hellen Karine</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Factorial design as tool in chitosan nanoparticles development by ionic gelation technique</atitle><jtitle>Colloids and surfaces. 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Since there are different kinds of chitosan, obtained from different sources of chitin and routes, it is very important to study which are the best conditions in order to obtain nanoparticles with desired size and superficial charge. The aim of this paper was to demonstrate to the scientific community how to obtain chitosan nanoparticles (nanoCTS) with these properties. Ionic gelation technique was applied to form nanoparticles through linkages between tripolyphosphate (TPP) and chitosan (CTS). The formulation was optimized using a 23 factorial design to analyze the effect of the pH, CTS:TPP ratio and acetic acid concentration in size and charge of the particles. The best formulation was characterized by FTIR, TGA, EDX and TEM analysis. The formation of nanoCTS depended mainly on ratio of CTS:TPP. Nanoparticles were obtained with excellent conditions for the application in pharmaceutical studies: average diameter of 76.2nm and zeta potential of 32.6mV.</abstract><pub>Elsevier B.V</pub><doi>10.1016/j.colsurfa.2013.12.058</doi><tpages>6</tpages></addata></record> |
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| subjects | Charge Chitosan Experimental design Factorial design Formulations Gelation Ionic gelation Nanoparticles Nanostructure Tripolyphosphate Zeta potential |
| title | Factorial design as tool in chitosan nanoparticles development by ionic gelation technique |
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