C/EBPβ knockdown protects cardiomyocytes from hypertrophy via inhibition of p65-NFκB

We investigated the role of C/EBPβ in mediating pathological cardiac hypertrophy. The results showed that the expression of C/EBPβ were significantly increased in response to hypertrophic stimulation in vitro and in vivo. C/EBPβ knockdown diminished the nuclear translocation and DNA binding activity...

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Veröffentlicht in:	Molecular and cellular endocrinology 2014-06, Vol.390 (1-2), p.18-25
Hauptverfasser:	Zou, Jian, Li, Hong, Chen, Xi, Zeng, Siyu, Ye, Jiantao, Zhou, Changhua, Liu, Min, Zhang, Luankun, Yu, Na, Gan, Xiaohong, Zhou, Houfeng, Xian, Zhiwei, Chen, Shaorui, Liu, Peiqing
Format:	Artikel
Sprache:	eng
Schlagworte:	Active Transport, Cell Nucleus Animals Binding Biomedical materials C/EBPβ Cardiac hypertrophy CCAAT-Enhancer-Binding Protein-beta - genetics CCAAT-Enhancer-Binding Protein-beta - metabolism Cells, Cultured DNA - metabolism Electrophoretic Mobility Shift Assay Gene Expression Gene Knockdown Techniques Genes Hypertrophy - metabolism In vivo testing In vivo tests Inhibition Inhibitors Myocytes, Cardiac - metabolism Myocytes, Cardiac - pathology p65-NFκB Protein Binding Rats, Sprague-Dawley Stimulation Transcription Factor RelA - genetics Transcription Factor RelA - metabolism
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