Bioaccumulation and Toxicodynamics of Cadmium to Freshwater Planarian and the Protective Effect of N-Acetylcysteine
Although toxic responses of freshwater planarians after exposure to environmental toxicants can be observed through external toxicological end points, physiological responses inside the bodies of treated planarians have rarely been investigated. The present study was designed, using cadmium (Cd) as...
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| Veröffentlicht in: | Archives of environmental contamination and toxicology 2012-08, Vol.63 (2), p.220-229 |
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| creator | Wu, Jui-Pin Chen, Hon-Cheng Li, Mei-Hui |
| description | Although toxic responses of freshwater planarians after exposure to environmental toxicants can be observed through external toxicological end points, physiological responses inside the bodies of treated planarians have rarely been investigated. The present study was designed, using cadmium (Cd) as a reference toxicant, to determine its bioaccumulation and toxicodynamics in the freshwater planarian,
Dugesia japonica
, after acute toxicity was obtained. Accumulated Cd concentrations, metallothionein levels, and the oxidative status in planarians were determined after exposure to Cd. Furthermore, we hypothesized that the acute death of Cd-treated planarians was associated with increased oxidative stress. After Cd-treated planarians were coexposed to antioxidant,
N
-acetylcysteine (NAC), we found that NAC protected planarians from Cd lethality by maintaining the oxidative status and decreasing the bioaccumulation of Cd. The results of the present study support planarians being used as a practical model for toxicological studies of environmental contaminants in the future. |
| doi_str_mv | 10.1007/s00244-012-9764-5 |
| format | Article |
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Dugesia japonica
, after acute toxicity was obtained. Accumulated Cd concentrations, metallothionein levels, and the oxidative status in planarians were determined after exposure to Cd. Furthermore, we hypothesized that the acute death of Cd-treated planarians was associated with increased oxidative stress. After Cd-treated planarians were coexposed to antioxidant,
N
-acetylcysteine (NAC), we found that NAC protected planarians from Cd lethality by maintaining the oxidative status and decreasing the bioaccumulation of Cd. The results of the present study support planarians being used as a practical model for toxicological studies of environmental contaminants in the future.</description><identifier>ISSN: 0090-4341</identifier><identifier>EISSN: 1432-0703</identifier><identifier>DOI: 10.1007/s00244-012-9764-5</identifier><identifier>PMID: 22481525</identifier><identifier>CODEN: AECTCV</identifier><language>eng</language><publisher>New York: Springer-Verlag</publisher><subject>Acetylcysteine - administration & dosage ; Acetylcysteine - pharmacology ; Acute toxicity ; Animal, plant and microbial ecology ; Animals ; Antioxidants ; Applied ecology ; Bioaccumulation ; Biological and medical sciences ; Cadmium ; Cadmium - analysis ; Cadmium - toxicity ; Contaminants ; Earth and Environmental Science ; Ecotoxicology ; Ecotoxicology, biological effects of pollution ; Environment ; Environmental Chemistry ; Environmental Health ; Environmental impact ; Environmental studies ; Enzymes ; Experiments ; Free Radical Scavengers - administration & dosage ; Free Radical Scavengers - pharmacology ; Freshwaters ; Fundamental and applied biological sciences. Psychology ; General aspects ; Hazardous materials ; Indicator organisms ; Laboratories ; Lethality ; Metal concentrations ; Metals ; Models, Animal ; Monitoring/Environmental Analysis ; Morphology ; Oxidative stress ; Oxidative Stress - drug effects ; Physiological responses ; Physiology ; Planarians - chemistry ; Planarians - drug effects ; Planarians - metabolism ; Pollution ; Random Allocation ; Soil Science & Conservation ; Studies ; Toxicants ; Toxicity ; Toxicity Tests, Acute ; Toxicology ; Water Pollutants, Chemical - analysis ; Water Pollutants, Chemical - toxicity ; Water pollution</subject><ispartof>Archives of environmental contamination and toxicology, 2012-08, Vol.63 (2), p.220-229</ispartof><rights>Springer Science+Business Media, LLC 2012</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c511t-e0944c1820c68b6cabaa26df4e7d69da5cf643079287ab90fb7e4443b40886c43</citedby><cites>FETCH-LOGICAL-c511t-e0944c1820c68b6cabaa26df4e7d69da5cf643079287ab90fb7e4443b40886c43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00244-012-9764-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00244-012-9764-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>315,781,785,27929,27930,41493,42562,51324</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26300141$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22481525$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wu, Jui-Pin</creatorcontrib><creatorcontrib>Chen, Hon-Cheng</creatorcontrib><creatorcontrib>Li, Mei-Hui</creatorcontrib><title>Bioaccumulation and Toxicodynamics of Cadmium to Freshwater Planarian and the Protective Effect of N-Acetylcysteine</title><title>Archives of environmental contamination and toxicology</title><addtitle>Arch Environ Contam Toxicol</addtitle><addtitle>Arch Environ Contam Toxicol</addtitle><description>Although toxic responses of freshwater planarians after exposure to environmental toxicants can be observed through external toxicological end points, physiological responses inside the bodies of treated planarians have rarely been investigated. The present study was designed, using cadmium (Cd) as a reference toxicant, to determine its bioaccumulation and toxicodynamics in the freshwater planarian,
Dugesia japonica
, after acute toxicity was obtained. Accumulated Cd concentrations, metallothionein levels, and the oxidative status in planarians were determined after exposure to Cd. Furthermore, we hypothesized that the acute death of Cd-treated planarians was associated with increased oxidative stress. After Cd-treated planarians were coexposed to antioxidant,
N
-acetylcysteine (NAC), we found that NAC protected planarians from Cd lethality by maintaining the oxidative status and decreasing the bioaccumulation of Cd. The results of the present study support planarians being used as a practical model for toxicological studies of environmental contaminants in the future.</description><subject>Acetylcysteine - administration & dosage</subject><subject>Acetylcysteine - pharmacology</subject><subject>Acute toxicity</subject><subject>Animal, plant and microbial ecology</subject><subject>Animals</subject><subject>Antioxidants</subject><subject>Applied ecology</subject><subject>Bioaccumulation</subject><subject>Biological and medical sciences</subject><subject>Cadmium</subject><subject>Cadmium - analysis</subject><subject>Cadmium - toxicity</subject><subject>Contaminants</subject><subject>Earth and Environmental Science</subject><subject>Ecotoxicology</subject><subject>Ecotoxicology, biological effects of pollution</subject><subject>Environment</subject><subject>Environmental Chemistry</subject><subject>Environmental Health</subject><subject>Environmental impact</subject><subject>Environmental studies</subject><subject>Enzymes</subject><subject>Experiments</subject><subject>Free Radical Scavengers - administration & dosage</subject><subject>Free Radical Scavengers - pharmacology</subject><subject>Freshwaters</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>General aspects</subject><subject>Hazardous materials</subject><subject>Indicator organisms</subject><subject>Laboratories</subject><subject>Lethality</subject><subject>Metal concentrations</subject><subject>Metals</subject><subject>Models, Animal</subject><subject>Monitoring/Environmental Analysis</subject><subject>Morphology</subject><subject>Oxidative stress</subject><subject>Oxidative Stress - drug effects</subject><subject>Physiological responses</subject><subject>Physiology</subject><subject>Planarians - chemistry</subject><subject>Planarians - drug effects</subject><subject>Planarians - metabolism</subject><subject>Pollution</subject><subject>Random Allocation</subject><subject>Soil Science & Conservation</subject><subject>Studies</subject><subject>Toxicants</subject><subject>Toxicity</subject><subject>Toxicity Tests, Acute</subject><subject>Toxicology</subject><subject>Water Pollutants, Chemical - analysis</subject><subject>Water Pollutants, Chemical - toxicity</subject><subject>Water pollution</subject><issn>0090-4341</issn><issn>1432-0703</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkV9r1TAYh4M43HH6AbyRgAjedCbp2yS9nIdNhaG7mNflbZq4jLaZSaqeb28OPeoYiFcJ5Pm9f_IQ8oKzU86YepsYEwAV46JqlYSqeUQ2HGpRMcXqx2TDWMsqqIEfk6cp3bICag1PyLEQoHkjmg1J73xAY5ZpGTH7MFOcB3odfnoTht2MkzeJBke3OEx-mWgO9CLadPMDs430asQZo8c1lW8svYohW5P9d0vPnSu3ffhTdWZs3o1ml7L1s31GjhyOyT4_nCfky8X59fZDdfn5_cft2WVlGs5zZVkLYLgWzEjdS4M9opCDA6sG2Q7YGCehZqoVWmHfMtcrCwB1D0xraaA-IW_WuncxfFtsyt3kk7FjmdqGJXVcKt40bQPq_yhra5B1q2VBXz1Ab8MS57JIoYRU5e_1vjdfKRNDStG67i76CeOuQN1eXrfK64qTbi-va0rm5aHy0k92-JP4basArw8AJoOjizgbn_5ysi6KgRdOrFwqT_NXG--P-K_uvwDqnbDz</recordid><startdate>20120801</startdate><enddate>20120801</enddate><creator>Wu, Jui-Pin</creator><creator>Chen, Hon-Cheng</creator><creator>Li, Mei-Hui</creator><general>Springer-Verlag</general><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T7</scope><scope>7TV</scope><scope>7U7</scope><scope>7WY</scope><scope>7WZ</scope><scope>7X7</scope><scope>7XB</scope><scope>87Z</scope><scope>88E</scope><scope>88I</scope><scope>8C1</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8FL</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BEZIV</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FRNLG</scope><scope>FYUFA</scope><scope>F~G</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K60</scope><scope>K6~</scope><scope>K9.</scope><scope>L.-</scope><scope>M0C</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>P64</scope><scope>PATMY</scope><scope>PQBIZ</scope><scope>PQBZA</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PYCSY</scope><scope>Q9U</scope><scope>7SU</scope><scope>KR7</scope></search><sort><creationdate>20120801</creationdate><title>Bioaccumulation and Toxicodynamics of Cadmium to Freshwater Planarian and the Protective Effect of N-Acetylcysteine</title><author>Wu, Jui-Pin ; Chen, Hon-Cheng ; Li, Mei-Hui</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c511t-e0944c1820c68b6cabaa26df4e7d69da5cf643079287ab90fb7e4443b40886c43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Acetylcysteine - administration & dosage</topic><topic>Acetylcysteine - pharmacology</topic><topic>Acute toxicity</topic><topic>Animal, plant and microbial ecology</topic><topic>Animals</topic><topic>Antioxidants</topic><topic>Applied ecology</topic><topic>Bioaccumulation</topic><topic>Biological and medical sciences</topic><topic>Cadmium</topic><topic>Cadmium - analysis</topic><topic>Cadmium - toxicity</topic><topic>Contaminants</topic><topic>Earth and Environmental Science</topic><topic>Ecotoxicology</topic><topic>Ecotoxicology, biological effects of pollution</topic><topic>Environment</topic><topic>Environmental Chemistry</topic><topic>Environmental Health</topic><topic>Environmental impact</topic><topic>Environmental studies</topic><topic>Enzymes</topic><topic>Experiments</topic><topic>Free Radical Scavengers - administration & dosage</topic><topic>Free Radical Scavengers - pharmacology</topic><topic>Freshwaters</topic><topic>Fundamental and applied biological sciences. 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pollution</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wu, Jui-Pin</creatorcontrib><creatorcontrib>Chen, Hon-Cheng</creatorcontrib><creatorcontrib>Li, Mei-Hui</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Pollution Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Access via ABI/INFORM (ProQuest)</collection><collection>ABI/INFORM Global (PDF only)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ABI/INFORM Global (Alumni 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Science Database</collection><collection>ProQuest One Business</collection><collection>ProQuest One Business (Alumni)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Environmental Science Collection</collection><collection>ProQuest Central Basic</collection><collection>Environmental Engineering Abstracts</collection><collection>Civil Engineering Abstracts</collection><jtitle>Archives of environmental contamination and toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wu, Jui-Pin</au><au>Chen, Hon-Cheng</au><au>Li, Mei-Hui</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bioaccumulation and Toxicodynamics of Cadmium to Freshwater Planarian and the Protective Effect of N-Acetylcysteine</atitle><jtitle>Archives of environmental contamination and toxicology</jtitle><stitle>Arch Environ Contam Toxicol</stitle><addtitle>Arch Environ Contam Toxicol</addtitle><date>2012-08-01</date><risdate>2012</risdate><volume>63</volume><issue>2</issue><spage>220</spage><epage>229</epage><pages>220-229</pages><issn>0090-4341</issn><eissn>1432-0703</eissn><coden>AECTCV</coden><abstract>Although toxic responses of freshwater planarians after exposure to environmental toxicants can be observed through external toxicological end points, physiological responses inside the bodies of treated planarians have rarely been investigated. The present study was designed, using cadmium (Cd) as a reference toxicant, to determine its bioaccumulation and toxicodynamics in the freshwater planarian,
Dugesia japonica
, after acute toxicity was obtained. Accumulated Cd concentrations, metallothionein levels, and the oxidative status in planarians were determined after exposure to Cd. Furthermore, we hypothesized that the acute death of Cd-treated planarians was associated with increased oxidative stress. After Cd-treated planarians were coexposed to antioxidant,
N
-acetylcysteine (NAC), we found that NAC protected planarians from Cd lethality by maintaining the oxidative status and decreasing the bioaccumulation of Cd. The results of the present study support planarians being used as a practical model for toxicological studies of environmental contaminants in the future.</abstract><cop>New York</cop><pub>Springer-Verlag</pub><pmid>22481525</pmid><doi>10.1007/s00244-012-9764-5</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Archives of environmental contamination and toxicology, 2012-08, Vol.63 (2), p.220-229 |
| issn | 0090-4341 1432-0703 |
| language | eng |
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| source | MEDLINE; SpringerNature Journals |
| subjects | Acetylcysteine - administration & dosage Acetylcysteine - pharmacology Acute toxicity Animal, plant and microbial ecology Animals Antioxidants Applied ecology Bioaccumulation Biological and medical sciences Cadmium Cadmium - analysis Cadmium - toxicity Contaminants Earth and Environmental Science Ecotoxicology Ecotoxicology, biological effects of pollution Environment Environmental Chemistry Environmental Health Environmental impact Environmental studies Enzymes Experiments Free Radical Scavengers - administration & dosage Free Radical Scavengers - pharmacology Freshwaters Fundamental and applied biological sciences. Psychology General aspects Hazardous materials Indicator organisms Laboratories Lethality Metal concentrations Metals Models, Animal Monitoring/Environmental Analysis Morphology Oxidative stress Oxidative Stress - drug effects Physiological responses Physiology Planarians - chemistry Planarians - drug effects Planarians - metabolism Pollution Random Allocation Soil Science & Conservation Studies Toxicants Toxicity Toxicity Tests, Acute Toxicology Water Pollutants, Chemical - analysis Water Pollutants, Chemical - toxicity Water pollution |
| title | Bioaccumulation and Toxicodynamics of Cadmium to Freshwater Planarian and the Protective Effect of N-Acetylcysteine |
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