Directed Ruthenium-Catalyzed C(sp super(3))--H [alpha]-Alkylation of Cyclic Amines Using Dioxolane-Protected Alkenones

A catalytic system for ruthenium-catalyzed C(sp super(3))--H [alpha]-alkylation of piperidines with dioxolane-protected alkenones is reported. Dioxolane protection of the ketone proved crucial to obtain alkylation products. A diverse set of highly substituted piperidines was readily prepared in mode...

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Veröffentlicht in:	Advanced synthesis & catalysis 2014-05, Vol.356 (7), p.1610-1618
Hauptverfasser:	Kulago, Artem A, VanSteijvoort, Ben F, Mitchell, Emily A, Meerpoel, Lieven, Maes, Bert UW
Format:	Artikel
Sprache:	eng
Schlagworte:	Accessibility Amines Catalysis Derivatives Ketones Methodology Piperidine Synthesis
Online-Zugang:	Volltext
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