LaB6 nanoparticles with carbon-doped silica coating for fluorescence imaging and near-IR photothermal therapy of cancer cells
In this study, LaB6 nanoparticles are used as a novel nanomaterial for near-infrared (NIR) photothermal therapy because they are cheaper than nanostructured gold, are easy to prepare and have an excellent NIR photothermal conversion property. Furthermore, the surface of LaB6 nanoparticles is coated...
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| Veröffentlicht in: | Acta biomaterialia 2013-07, Vol.9 (7), p.7556-7563 |
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| creator | Lai, B.-H. Chen, D.-H. |
| description | In this study, LaB6 nanoparticles are used as a novel nanomaterial for near-infrared (NIR) photothermal therapy because they are cheaper than nanostructured gold, are easy to prepare and have an excellent NIR photothermal conversion property. Furthermore, the surface of LaB6 nanoparticles is coated with a carbon-doped silica (C-SiO2) shell to introduce a fluorescent property and improve stability and biocompatibility. The resulting LaB6@C-SiO2 nanoparticles retain the excellent NIR photothermal conversion property and exhibit a bright blue emission under UV irradiation or a green emission under visible irradiation. Using a HeLa cancer cell line, it is demonstrated that LaB6@C-SiO2 nanoparticles have no significant cytotoxicity, but their presence leads to remarkable cell death after NIR irradiation. In addition, from the observation of cellular uptake, the fluorescence labeling function of LaB6@SiO2 (LaB6 core/SiO2 shell) nanoparticles is also confirmed. These results suggest that LaB6@C-SiO2 nanoparticles may potentially serve as an efficient multifunctional nano-platform for simultaneous fluorescent imaging and NIR-triggered photothermal therapy of cancer cells. |
| doi_str_mv | 10.1016/j.actbio.2013.03.034 |
| format | Article |
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Furthermore, the surface of LaB6 nanoparticles is coated with a carbon-doped silica (C-SiO2) shell to introduce a fluorescent property and improve stability and biocompatibility. The resulting LaB6@C-SiO2 nanoparticles retain the excellent NIR photothermal conversion property and exhibit a bright blue emission under UV irradiation or a green emission under visible irradiation. Using a HeLa cancer cell line, it is demonstrated that LaB6@C-SiO2 nanoparticles have no significant cytotoxicity, but their presence leads to remarkable cell death after NIR irradiation. In addition, from the observation of cellular uptake, the fluorescence labeling function of LaB6@SiO2 (LaB6 core/SiO2 shell) nanoparticles is also confirmed. These results suggest that LaB6@C-SiO2 nanoparticles may potentially serve as an efficient multifunctional nano-platform for simultaneous fluorescent imaging and NIR-triggered photothermal therapy of cancer cells.</description><identifier>ISSN: 1742-7061</identifier><identifier>EISSN: 1878-7568</identifier><identifier>DOI: 10.1016/j.actbio.2013.03.034</identifier><identifier>PMID: 23542555</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>biocompatibility ; Boron Compounds ; Cancer ; Carbon - chemistry ; Carbon-doped SiO2 ; cell death ; Coated Materials, Biocompatible - chemical synthesis ; Coated Materials, Biocompatible - therapeutic use ; coatings ; cytotoxicity ; fluorescence ; Fluorescence imaging ; Fluorescent Dyes - chemical synthesis ; fluorescent labeling ; gold ; HeLa Cells ; Humans ; Hyperthermia, Induced - methods ; image analysis ; Imaging ; Infrared Rays ; Irradiation ; LaB6 nanoparticles ; Lanthanum ; Microscopy, Fluorescence - methods ; Nanomaterials ; Nanoparticles ; Nanoparticles - chemistry ; Nanoparticles - therapeutic use ; Nanostructure ; Near infrared ; Neoplasms, Experimental - pathology ; Neoplasms, Experimental - therapy ; Particle Size ; Phototherapy - methods ; Photothermal therapy ; silica ; Silicon dioxide ; Silicon Dioxide - chemistry ; therapeutics ; Therapy ; Treatment Outcome ; ultraviolet radiation</subject><ispartof>Acta biomaterialia, 2013-07, Vol.9 (7), p.7556-7563</ispartof><rights>2013 Acta Materialia Inc.</rights><rights>Copyright © 2013 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c452t-f365a797678ff475c041293a46ddbc4883bbdab3c7a4a82bb7ee6a08e32baf423</citedby><cites>FETCH-LOGICAL-c452t-f365a797678ff475c041293a46ddbc4883bbdab3c7a4a82bb7ee6a08e32baf423</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1742706113001645$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23542555$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lai, B.-H.</creatorcontrib><creatorcontrib>Chen, D.-H.</creatorcontrib><title>LaB6 nanoparticles with carbon-doped silica coating for fluorescence imaging and near-IR photothermal therapy of cancer cells</title><title>Acta biomaterialia</title><addtitle>Acta Biomater</addtitle><description>In this study, LaB6 nanoparticles are used as a novel nanomaterial for near-infrared (NIR) photothermal therapy because they are cheaper than nanostructured gold, are easy to prepare and have an excellent NIR photothermal conversion property. Furthermore, the surface of LaB6 nanoparticles is coated with a carbon-doped silica (C-SiO2) shell to introduce a fluorescent property and improve stability and biocompatibility. The resulting LaB6@C-SiO2 nanoparticles retain the excellent NIR photothermal conversion property and exhibit a bright blue emission under UV irradiation or a green emission under visible irradiation. Using a HeLa cancer cell line, it is demonstrated that LaB6@C-SiO2 nanoparticles have no significant cytotoxicity, but their presence leads to remarkable cell death after NIR irradiation. In addition, from the observation of cellular uptake, the fluorescence labeling function of LaB6@SiO2 (LaB6 core/SiO2 shell) nanoparticles is also confirmed. These results suggest that LaB6@C-SiO2 nanoparticles may potentially serve as an efficient multifunctional nano-platform for simultaneous fluorescent imaging and NIR-triggered photothermal therapy of cancer cells.</description><subject>biocompatibility</subject><subject>Boron Compounds</subject><subject>Cancer</subject><subject>Carbon - chemistry</subject><subject>Carbon-doped SiO2</subject><subject>cell death</subject><subject>Coated Materials, Biocompatible - chemical synthesis</subject><subject>Coated Materials, Biocompatible - therapeutic use</subject><subject>coatings</subject><subject>cytotoxicity</subject><subject>fluorescence</subject><subject>Fluorescence imaging</subject><subject>Fluorescent Dyes - chemical synthesis</subject><subject>fluorescent labeling</subject><subject>gold</subject><subject>HeLa Cells</subject><subject>Humans</subject><subject>Hyperthermia, Induced - methods</subject><subject>image analysis</subject><subject>Imaging</subject><subject>Infrared Rays</subject><subject>Irradiation</subject><subject>LaB6 nanoparticles</subject><subject>Lanthanum</subject><subject>Microscopy, Fluorescence - methods</subject><subject>Nanomaterials</subject><subject>Nanoparticles</subject><subject>Nanoparticles - chemistry</subject><subject>Nanoparticles - therapeutic use</subject><subject>Nanostructure</subject><subject>Near infrared</subject><subject>Neoplasms, Experimental - pathology</subject><subject>Neoplasms, Experimental - therapy</subject><subject>Particle Size</subject><subject>Phototherapy - methods</subject><subject>Photothermal therapy</subject><subject>silica</subject><subject>Silicon dioxide</subject><subject>Silicon Dioxide - chemistry</subject><subject>therapeutics</subject><subject>Therapy</subject><subject>Treatment Outcome</subject><subject>ultraviolet radiation</subject><issn>1742-7061</issn><issn>1878-7568</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU-LFDEQxRtR3HX1G4jm6KXH_E_6IriLqwsDgrrnUEknMxl6Om3So-zB775pevXoQkEF8ntVj3pN85rgDcFEvj9swM02pg3FhG3wUvxJc0600q0SUj-tb8Vpq7AkZ82LUg4YM02oft6cUSY4FUKcN3-2cCnRCGOaIM_RDb6g33HeIwfZprHt0-R7VOIQHSCXYI7jDoWUURhOKfvi_Og8ikfYLR8w9mj0kNubb2japznNe5-PMKClw3SHUqiDqyIj54ehvGyeBRiKf_XQL5rb608_rr6026-fb64-blvHBZ3bwKQA1SmpdAhcCYc5oR0DLvveOq41s7YHy5wCDppaq7yXgLVn1ELglF0079a5U04_T77M5hjL4gBGn07FEKmI4IJQ9jhaVwvSMSUfR5lQvFOMLgb4irqcSsk-mCnXo-U7Q7BZ4jQHs8ZpljgNXopX2ZuHDSd79P0_0d_8KvB2BQIkA7sci7n9XicIjAnWnVSV-LASvt73V_TZFBeX0PqYvZtNn-L_PdwDkVC8sw</recordid><startdate>20130701</startdate><enddate>20130701</enddate><creator>Lai, B.-H.</creator><creator>Chen, D.-H.</creator><general>Elsevier Ltd</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7SR</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>F28</scope><scope>JG9</scope><scope>L7M</scope></search><sort><creationdate>20130701</creationdate><title>LaB6 nanoparticles with carbon-doped silica coating for fluorescence imaging and near-IR photothermal therapy of cancer cells</title><author>Lai, B.-H. ; Chen, D.-H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c452t-f365a797678ff475c041293a46ddbc4883bbdab3c7a4a82bb7ee6a08e32baf423</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>biocompatibility</topic><topic>Boron Compounds</topic><topic>Cancer</topic><topic>Carbon - chemistry</topic><topic>Carbon-doped SiO2</topic><topic>cell death</topic><topic>Coated Materials, Biocompatible - chemical synthesis</topic><topic>Coated Materials, Biocompatible - therapeutic use</topic><topic>coatings</topic><topic>cytotoxicity</topic><topic>fluorescence</topic><topic>Fluorescence imaging</topic><topic>Fluorescent Dyes - chemical synthesis</topic><topic>fluorescent labeling</topic><topic>gold</topic><topic>HeLa Cells</topic><topic>Humans</topic><topic>Hyperthermia, Induced - methods</topic><topic>image analysis</topic><topic>Imaging</topic><topic>Infrared Rays</topic><topic>Irradiation</topic><topic>LaB6 nanoparticles</topic><topic>Lanthanum</topic><topic>Microscopy, Fluorescence - methods</topic><topic>Nanomaterials</topic><topic>Nanoparticles</topic><topic>Nanoparticles - chemistry</topic><topic>Nanoparticles - therapeutic use</topic><topic>Nanostructure</topic><topic>Near infrared</topic><topic>Neoplasms, Experimental - pathology</topic><topic>Neoplasms, Experimental - therapy</topic><topic>Particle Size</topic><topic>Phototherapy - methods</topic><topic>Photothermal therapy</topic><topic>silica</topic><topic>Silicon dioxide</topic><topic>Silicon Dioxide - chemistry</topic><topic>therapeutics</topic><topic>Therapy</topic><topic>Treatment Outcome</topic><topic>ultraviolet radiation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lai, B.-H.</creatorcontrib><creatorcontrib>Chen, D.-H.</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Acta biomaterialia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lai, B.-H.</au><au>Chen, D.-H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>LaB6 nanoparticles with carbon-doped silica coating for fluorescence imaging and near-IR photothermal therapy of cancer cells</atitle><jtitle>Acta biomaterialia</jtitle><addtitle>Acta Biomater</addtitle><date>2013-07-01</date><risdate>2013</risdate><volume>9</volume><issue>7</issue><spage>7556</spage><epage>7563</epage><pages>7556-7563</pages><issn>1742-7061</issn><eissn>1878-7568</eissn><abstract>In this study, LaB6 nanoparticles are used as a novel nanomaterial for near-infrared (NIR) photothermal therapy because they are cheaper than nanostructured gold, are easy to prepare and have an excellent NIR photothermal conversion property. Furthermore, the surface of LaB6 nanoparticles is coated with a carbon-doped silica (C-SiO2) shell to introduce a fluorescent property and improve stability and biocompatibility. The resulting LaB6@C-SiO2 nanoparticles retain the excellent NIR photothermal conversion property and exhibit a bright blue emission under UV irradiation or a green emission under visible irradiation. Using a HeLa cancer cell line, it is demonstrated that LaB6@C-SiO2 nanoparticles have no significant cytotoxicity, but their presence leads to remarkable cell death after NIR irradiation. In addition, from the observation of cellular uptake, the fluorescence labeling function of LaB6@SiO2 (LaB6 core/SiO2 shell) nanoparticles is also confirmed. These results suggest that LaB6@C-SiO2 nanoparticles may potentially serve as an efficient multifunctional nano-platform for simultaneous fluorescent imaging and NIR-triggered photothermal therapy of cancer cells.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>23542555</pmid><doi>10.1016/j.actbio.2013.03.034</doi><tpages>8</tpages></addata></record> |
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| subjects | biocompatibility Boron Compounds Cancer Carbon - chemistry Carbon-doped SiO2 cell death Coated Materials, Biocompatible - chemical synthesis Coated Materials, Biocompatible - therapeutic use coatings cytotoxicity fluorescence Fluorescence imaging Fluorescent Dyes - chemical synthesis fluorescent labeling gold HeLa Cells Humans Hyperthermia, Induced - methods image analysis Imaging Infrared Rays Irradiation LaB6 nanoparticles Lanthanum Microscopy, Fluorescence - methods Nanomaterials Nanoparticles Nanoparticles - chemistry Nanoparticles - therapeutic use Nanostructure Near infrared Neoplasms, Experimental - pathology Neoplasms, Experimental - therapy Particle Size Phototherapy - methods Photothermal therapy silica Silicon dioxide Silicon Dioxide - chemistry therapeutics Therapy Treatment Outcome ultraviolet radiation |
| title | LaB6 nanoparticles with carbon-doped silica coating for fluorescence imaging and near-IR photothermal therapy of cancer cells |
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