Quinacrine reactivity with prion proteins and prion-derived peptides

Quinacrine is a drug that is known to heal neuronal cell culture infected with prions, which are the causative agents of neurodegenerative diseases called transmissible spongiform encephalopathies. However, the drug fails when it is applied in vivo. In this work, we analyzed the reason for this fail...

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Veröffentlicht in:	Amino acids 2013-05, Vol.44 (5), p.1279-1292
Hauptverfasser:	Zawada, Zbigniew, Šafařík, Martin, Dvořáková, Eva, Janoušková, Olga, Březinová, Anna, Stibor, Ivan, Holada, Karel, Bouř, Petr, Hlaváček, Jan, Šebestík, Jaroslav
Format:	Artikel
Sprache:	eng
Schlagworte:	Acridines - chemistry Amino Acid Sequence Amino acids Analytical Chemistry Biochemical Engineering Biochemistry Biomedical and Life Sciences Covalence Cysteine - chemistry Drugs Failure Humans Life Sciences Neurobiology Original Article Peptide Fragments - chemistry Peptides Prions Prions - chemistry Proteins Proteomics Quinacrine - chemistry Spectrometry, Fluorescence Spectrophotometry, Ultraviolet Thiols
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