Elucidation of the metabolic pathway of S-equol in rat, monkey and man

► 14C-S-equol metabolites were studied in plasma, urine and feces of rats and monkey. ► The 4′-gluconronide, the 7-sulfate, and the diconjugate were major metabolites. ► Similar metabolites were seen in hepatocytes from the rat, monkey and man. S-equol is a selective estrogen receptor β (ERβ) agonis...

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Veröffentlicht in:	Food and chemical toxicology 2012-06, Vol.50 (6), p.2074-2083
Hauptverfasser:	Schwen, Richard J., Nguyen, Linh, Jackson, Richard L.
Format:	Artikel
Sprache:	eng
Schlagworte:	agonists Animals biochemical pathways Biocompatibility Biological and medical sciences Biomedical materials Carbon Radioisotopes Chromatography, High Pressure Liquid Cryopreservation Cynomolgus daidzein Equol - pharmacokinetics estrogen receptors Feces - chemistry Glucuronides - metabolism Hepatocytes Hepatocytes - drug effects Humans in vitro studies In vitro testing In vivo testing In vivo tests ingestion Macaca fascicularis Male Mass Spectrometry Medical sciences menopause Metabolism Metabolite identification Metabolites Monkeys Phytoestrogens - pharmacokinetics Rats Rats, Sprague-Dawley S-equol Species Specificity Sulfates - metabolism Surgical implants Tissue Distribution Toxicology urine
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