Local protective effects of oral 45S5 bioactive glass on gastric ulcers in experimental animals
Bioactive glass has been shown to stimulate bone regeneration and soft tissue healing. In this study, we evaluated the local protective effects of bioactive glass on experimental gastric ulcers, in comparison with omeprazole and hydrotalcite. Single and multiple gavage of 45S5 bioactive glass dose-d...
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| Veröffentlicht in: | Journal of materials science. Materials in medicine 2013-03, Vol.24 (3), p.803-809 |
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| container_title | Journal of materials science. Materials in medicine |
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| creator | Ma, Ai-niu Gong, Nian Lu, Jin-miao Huang, Jin-lu Hao, Bin Guo, Yang Zhong, Jipin Xu, Yuhong Chang, Jiang Wang, Yong-xiang |
| description | Bioactive glass has been shown to stimulate bone regeneration and soft tissue healing. In this study, we evaluated the local protective effects of bioactive glass on experimental gastric ulcers, in comparison with omeprazole and hydrotalcite. Single and multiple gavage of 45S5 bioactive glass dose-dependently protected stress ulcers in mice and chronic ulcers in rats. Multi-daily gavage of bioactive glass for 7 days prevented chronic ulcer recurrence by 50 %. Bioactive glass ionic dissolution produced marked proliferation of ethanol-injured GES-1 human gastric mucosa epithelial cells 48 and 72 h after exposure. Bioactive glass was shown to be hardly absorbed after single or multi-daily gavage. This study, for the first time, demonstrates that bioactive glass is effective in protecting against gastric ulcers, with its high efficacy comparable to omeprazole and superior to hydrotalcite. The lack of oral absorption makes bioactive glass a potential for treatment of peptic ulcers omitting systemic toxicity or side-effects. |
| doi_str_mv | 10.1007/s10856-012-4844-7 |
| format | Article |
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In this study, we evaluated the local protective effects of bioactive glass on experimental gastric ulcers, in comparison with omeprazole and hydrotalcite. Single and multiple gavage of 45S5 bioactive glass dose-dependently protected stress ulcers in mice and chronic ulcers in rats. Multi-daily gavage of bioactive glass for 7 days prevented chronic ulcer recurrence by 50 %. Bioactive glass ionic dissolution produced marked proliferation of ethanol-injured GES-1 human gastric mucosa epithelial cells 48 and 72 h after exposure. Bioactive glass was shown to be hardly absorbed after single or multi-daily gavage. This study, for the first time, demonstrates that bioactive glass is effective in protecting against gastric ulcers, with its high efficacy comparable to omeprazole and superior to hydrotalcite. The lack of oral absorption makes bioactive glass a potential for treatment of peptic ulcers omitting systemic toxicity or side-effects.</description><identifier>ISSN: 0957-4530</identifier><identifier>EISSN: 1573-4838</identifier><identifier>DOI: 10.1007/s10856-012-4844-7</identifier><identifier>PMID: 23329370</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Administration, Oral ; Animals ; Biological and medical sciences ; Biomaterials ; Biomedical Engineering and Bioengineering ; Biomedical materials ; Bones ; Cell Line ; Ceramics ; Chemistry and Materials Science ; Composites ; Dissolution ; Gastric Mucosa - cytology ; Gastroenterology. Liver. Pancreas. Abdomen ; Gastrointestinal diseases ; Glass ; Humans ; Male ; Materials Science ; Medical sciences ; Mice ; Natural Materials ; Other diseases. Semiology ; Polymer Sciences ; Protective ; Rats ; Rats, Sprague-Dawley ; Recurrence ; Regenerative Medicine/Tissue Engineering ; Stomach Ulcer - prevention & control ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Surfaces and Interfaces ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Technology. Biomaterials. Equipments ; Thin Films ; Toxicity ; Ulcers</subject><ispartof>Journal of materials science. Materials in medicine, 2013-03, Vol.24 (3), p.803-809</ispartof><rights>Springer Science+Business Media New York 2013</rights><rights>2014 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c501t-e6d3c4b45f96c74a3aba1664384423cdeb90beca930f6298aaff994f02a0dd83</citedby><cites>FETCH-LOGICAL-c501t-e6d3c4b45f96c74a3aba1664384423cdeb90beca930f6298aaff994f02a0dd83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10856-012-4844-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10856-012-4844-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27394566$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23329370$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ma, Ai-niu</creatorcontrib><creatorcontrib>Gong, Nian</creatorcontrib><creatorcontrib>Lu, Jin-miao</creatorcontrib><creatorcontrib>Huang, Jin-lu</creatorcontrib><creatorcontrib>Hao, Bin</creatorcontrib><creatorcontrib>Guo, Yang</creatorcontrib><creatorcontrib>Zhong, Jipin</creatorcontrib><creatorcontrib>Xu, Yuhong</creatorcontrib><creatorcontrib>Chang, Jiang</creatorcontrib><creatorcontrib>Wang, Yong-xiang</creatorcontrib><title>Local protective effects of oral 45S5 bioactive glass on gastric ulcers in experimental animals</title><title>Journal of materials science. Materials in medicine</title><addtitle>J Mater Sci: Mater Med</addtitle><addtitle>J Mater Sci Mater Med</addtitle><description>Bioactive glass has been shown to stimulate bone regeneration and soft tissue healing. In this study, we evaluated the local protective effects of bioactive glass on experimental gastric ulcers, in comparison with omeprazole and hydrotalcite. Single and multiple gavage of 45S5 bioactive glass dose-dependently protected stress ulcers in mice and chronic ulcers in rats. Multi-daily gavage of bioactive glass for 7 days prevented chronic ulcer recurrence by 50 %. Bioactive glass ionic dissolution produced marked proliferation of ethanol-injured GES-1 human gastric mucosa epithelial cells 48 and 72 h after exposure. Bioactive glass was shown to be hardly absorbed after single or multi-daily gavage. This study, for the first time, demonstrates that bioactive glass is effective in protecting against gastric ulcers, with its high efficacy comparable to omeprazole and superior to hydrotalcite. The lack of oral absorption makes bioactive glass a potential for treatment of peptic ulcers omitting systemic toxicity or side-effects.</description><subject>Administration, Oral</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Biomaterials</subject><subject>Biomedical Engineering and Bioengineering</subject><subject>Biomedical materials</subject><subject>Bones</subject><subject>Cell Line</subject><subject>Ceramics</subject><subject>Chemistry and Materials Science</subject><subject>Composites</subject><subject>Dissolution</subject><subject>Gastric Mucosa - cytology</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Gastrointestinal diseases</subject><subject>Glass</subject><subject>Humans</subject><subject>Male</subject><subject>Materials Science</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Natural Materials</subject><subject>Other diseases. Semiology</subject><subject>Polymer Sciences</subject><subject>Protective</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Recurrence</subject><subject>Regenerative Medicine/Tissue Engineering</subject><subject>Stomach Ulcer - prevention & control</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><subject>Surfaces and Interfaces</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Technology. Biomaterials. 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Materials in medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ma, Ai-niu</au><au>Gong, Nian</au><au>Lu, Jin-miao</au><au>Huang, Jin-lu</au><au>Hao, Bin</au><au>Guo, Yang</au><au>Zhong, Jipin</au><au>Xu, Yuhong</au><au>Chang, Jiang</au><au>Wang, Yong-xiang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Local protective effects of oral 45S5 bioactive glass on gastric ulcers in experimental animals</atitle><jtitle>Journal of materials science. Materials in medicine</jtitle><stitle>J Mater Sci: Mater Med</stitle><addtitle>J Mater Sci Mater Med</addtitle><date>2013-03-01</date><risdate>2013</risdate><volume>24</volume><issue>3</issue><spage>803</spage><epage>809</epage><pages>803-809</pages><issn>0957-4530</issn><eissn>1573-4838</eissn><abstract>Bioactive glass has been shown to stimulate bone regeneration and soft tissue healing. In this study, we evaluated the local protective effects of bioactive glass on experimental gastric ulcers, in comparison with omeprazole and hydrotalcite. Single and multiple gavage of 45S5 bioactive glass dose-dependently protected stress ulcers in mice and chronic ulcers in rats. Multi-daily gavage of bioactive glass for 7 days prevented chronic ulcer recurrence by 50 %. Bioactive glass ionic dissolution produced marked proliferation of ethanol-injured GES-1 human gastric mucosa epithelial cells 48 and 72 h after exposure. Bioactive glass was shown to be hardly absorbed after single or multi-daily gavage. This study, for the first time, demonstrates that bioactive glass is effective in protecting against gastric ulcers, with its high efficacy comparable to omeprazole and superior to hydrotalcite. The lack of oral absorption makes bioactive glass a potential for treatment of peptic ulcers omitting systemic toxicity or side-effects.</abstract><cop>Boston</cop><pub>Springer US</pub><pmid>23329370</pmid><doi>10.1007/s10856-012-4844-7</doi><tpages>7</tpages></addata></record> |
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| subjects | Administration, Oral Animals Biological and medical sciences Biomaterials Biomedical Engineering and Bioengineering Biomedical materials Bones Cell Line Ceramics Chemistry and Materials Science Composites Dissolution Gastric Mucosa - cytology Gastroenterology. Liver. Pancreas. Abdomen Gastrointestinal diseases Glass Humans Male Materials Science Medical sciences Mice Natural Materials Other diseases. Semiology Polymer Sciences Protective Rats Rats, Sprague-Dawley Recurrence Regenerative Medicine/Tissue Engineering Stomach Ulcer - prevention & control Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Surfaces and Interfaces Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Technology. Biomaterials. Equipments Thin Films Toxicity Ulcers |
| title | Local protective effects of oral 45S5 bioactive glass on gastric ulcers in experimental animals |
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