Pedigree transmission disequilibrium test for quantitative traits in farm animals
General pedigrees are very common in farm animals, and the recent availability of large panels of SNPs in domestic species has given new momentum to the search for the mutations underlying variation in quantitative traits. In this paper, we proposed a new transmission disequilibrium test approach, c...
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| Veröffentlicht in: | Chinese science bulletin 2012-07, Vol.57 (21), p.2688-2694 |
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| creator | Ding, XiangDong Wang, ChongLong Zhang, Qin |
| description | General pedigrees are very common in farm animals, and the recent availability of large panels of SNPs in domestic species has given new momentum to the search for the mutations underlying variation in quantitative traits. In this paper, we proposed a new transmission disequilibrium test approach, called the pedigree transmission disequilibrium test, which deals with general pedigrees and quantitative traits in farm animals. Compared with the existing pedigree disequilibrium test (PDT) and general linear model-based method QTDT, our approach performed better with higher power and lower type I error, especially in scenarios where the quantitative trait locus (QTL) effect was small. We also investigated the application of our approach in selective genotyping design. Our simulation studies indicated that it was plausible to implement a selective genotyping strategy in the proposed pedigree transmission disequilibrium test. We found that our approach performed equally well or better when only some proportion of the individuals in the two tails were genotyped compared with its performance when all the individuals in the pedigree were genotyped. |
| doi_str_mv | 10.1007/s11434-012-5218-8 |
| format | Article |
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Sci. Bull</addtitle><addtitle>Chinese Science Bulletin</addtitle><description>General pedigrees are very common in farm animals, and the recent availability of large panels of SNPs in domestic species has given new momentum to the search for the mutations underlying variation in quantitative traits. In this paper, we proposed a new transmission disequilibrium test approach, called the pedigree transmission disequilibrium test, which deals with general pedigrees and quantitative traits in farm animals. Compared with the existing pedigree disequilibrium test (PDT) and general linear model-based method QTDT, our approach performed better with higher power and lower type I error, especially in scenarios where the quantitative trait locus (QTL) effect was small. We also investigated the application of our approach in selective genotyping design. 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| source | EZB-FREE-00999 freely available EZB journals |
| subjects | Animals Availability Chemistry/Food Science Computer simulation Domestic Earth Sciences Engineering farmed animal species Farms genotyping Humanities and Social Sciences Life Sciences multidisciplinary Mutations pedigree Physics quantitative trait loci quantitative traits Science Science (multidisciplinary) Searching single nucleotide polymorphism Strategy 一般线性模型 不平衡 传递 基因分型 家畜 数量性状位点 检验方法 谱系 |
| title | Pedigree transmission disequilibrium test for quantitative traits in farm animals |
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