Preparation and characterization of nano-hydroxyapatite within chitosan matrix
Nano-composites that show some features of natural bone both in composition and in microstructure have been prepared by in situ precipitation method. Apatite phase has been prepared from cost-effective precursors (calcite and urea phosphate) within chitosan (CS) matrix dissolved in aqueous acetic ac...
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| Veröffentlicht in: | Materials Science & Engineering C 2013-12, Vol.33 (8), p.4539-4544 |
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| creator | Rogina, A. Ivanković, M. Ivanković, H. |
| description | Nano-composites that show some features of natural bone both in composition and in microstructure have been prepared by in situ precipitation method. Apatite phase has been prepared from cost-effective precursors (calcite and urea phosphate) within chitosan (CS) matrix dissolved in aqueous acetic acid solution. The compositional and morphological properties of composites were studied by means of Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD) thermogravimetric analysis (TGA) and transmission electron microscopy (TEM). Depending on the reaction conditions (temperature, reaction time, glucose addition and pH control) in addition to hydroxyapatite (HA) as a major phase, octacalcium hydrogen phosphate pentahydrate (OCP) and dicalcium phosphate anhydrate (DCPD) were formed as shown by XRD and FTIR. Crystallite lengths of precipitated HA estimated by Scherrer's equation were between 20 and 30nm. A fibrous morphology (~400nm) of HA observed by TEM indicates that HA nucleates on chitosan chains.
•Nano-hydroxyapatite (HA) was prepared by in situ precipitation within chitosan hydrogels and colloidal chitosan solution.•pH control was regulated by ammonia and urea degradation.•In situ urea degradation provides homogenous HA formation.•TEM imaging indicates fibrous morphology of HA with crystalline size of 400nm.•Glucose addition and temperature variation affect inorganic phase formation. |
| doi_str_mv | 10.1016/j.msec.2013.07.008 |
| format | Article |
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•Nano-hydroxyapatite (HA) was prepared by in situ precipitation within chitosan hydrogels and colloidal chitosan solution.•pH control was regulated by ammonia and urea degradation.•In situ urea degradation provides homogenous HA formation.•TEM imaging indicates fibrous morphology of HA with crystalline size of 400nm.•Glucose addition and temperature variation affect inorganic phase formation.</description><identifier>ISSN: 0928-4931</identifier><identifier>EISSN: 1873-0191</identifier><identifier>DOI: 10.1016/j.msec.2013.07.008</identifier><identifier>PMID: 24094157</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Acetic Acid - chemistry ; Bones ; Calcium Phosphates - chemistry ; Chitosan ; Chitosan - chemistry ; Crystallization ; Durapatite - chemistry ; Glucose - chemistry ; Hydrogen-Ion Concentration ; Hydroxyapatite ; In situ precipitation ; Mathematical analysis ; Microscopy, Electron, Transmission ; Nano-hydroxyapatite ; Nanocomposites ; Nanocomposites - chemistry ; Nanostructure ; Phosphates ; Spectroscopy, Fourier Transform Infrared ; Temperature ; Thermogravimetry ; Tissue Engineering ; Transmission electron microscopy ; X-Ray Diffraction</subject><ispartof>Materials Science & Engineering C, 2013-12, Vol.33 (8), p.4539-4544</ispartof><rights>2013 Elsevier B.V.</rights><rights>2013.</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c389t-748a8caf32ca8163bcfecb5661edd31175f3041ff7582f926e3d5e32a7a255273</citedby><cites>FETCH-LOGICAL-c389t-748a8caf32ca8163bcfecb5661edd31175f3041ff7582f926e3d5e32a7a255273</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.msec.2013.07.008$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24094157$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rogina, A.</creatorcontrib><creatorcontrib>Ivanković, M.</creatorcontrib><creatorcontrib>Ivanković, H.</creatorcontrib><title>Preparation and characterization of nano-hydroxyapatite within chitosan matrix</title><title>Materials Science & Engineering C</title><addtitle>Mater Sci Eng C Mater Biol Appl</addtitle><description>Nano-composites that show some features of natural bone both in composition and in microstructure have been prepared by in situ precipitation method. Apatite phase has been prepared from cost-effective precursors (calcite and urea phosphate) within chitosan (CS) matrix dissolved in aqueous acetic acid solution. The compositional and morphological properties of composites were studied by means of Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD) thermogravimetric analysis (TGA) and transmission electron microscopy (TEM). Depending on the reaction conditions (temperature, reaction time, glucose addition and pH control) in addition to hydroxyapatite (HA) as a major phase, octacalcium hydrogen phosphate pentahydrate (OCP) and dicalcium phosphate anhydrate (DCPD) were formed as shown by XRD and FTIR. Crystallite lengths of precipitated HA estimated by Scherrer's equation were between 20 and 30nm. A fibrous morphology (~400nm) of HA observed by TEM indicates that HA nucleates on chitosan chains.
•Nano-hydroxyapatite (HA) was prepared by in situ precipitation within chitosan hydrogels and colloidal chitosan solution.•pH control was regulated by ammonia and urea degradation.•In situ urea degradation provides homogenous HA formation.•TEM imaging indicates fibrous morphology of HA with crystalline size of 400nm.•Glucose addition and temperature variation affect inorganic phase formation.</description><subject>Acetic Acid - chemistry</subject><subject>Bones</subject><subject>Calcium Phosphates - chemistry</subject><subject>Chitosan</subject><subject>Chitosan - chemistry</subject><subject>Crystallization</subject><subject>Durapatite - chemistry</subject><subject>Glucose - chemistry</subject><subject>Hydrogen-Ion Concentration</subject><subject>Hydroxyapatite</subject><subject>In situ precipitation</subject><subject>Mathematical analysis</subject><subject>Microscopy, Electron, Transmission</subject><subject>Nano-hydroxyapatite</subject><subject>Nanocomposites</subject><subject>Nanocomposites - chemistry</subject><subject>Nanostructure</subject><subject>Phosphates</subject><subject>Spectroscopy, Fourier Transform Infrared</subject><subject>Temperature</subject><subject>Thermogravimetry</subject><subject>Tissue Engineering</subject><subject>Transmission electron microscopy</subject><subject>X-Ray Diffraction</subject><issn>0928-4931</issn><issn>1873-0191</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1PGzEQhq2qqATaP8AB7bGXXTz2eu2VuCDEl4RKD3C2HO9YcZRdp7YDhF9fR6Ec6Wk0o-d9NXoIOQHaAIXubNmMCW3DKPCGyoZS9YXMQEleU-jhK5nRnqm67TkckqOUlpR2ikv2jRyylvYtCDkjv35HXJtosg9TZaahsouy2YzRv-2PwVWTmUK92A4xvG7NupwzVi8-L_xUcJ9DMlM1mhz963dy4Mwq4Y_3eUyerq8eL2_r-4ebu8uL-9py1edatsooaxxn1ijo-Nw6tHPRdYDDwAGkcJy24JwUirmedcgHgZwZaZgQTPJj8nPfu47hzwZT1qNPFlcrM2HYJA2dBMGEpOL_aNvy8pQEVVC2R20MKUV0eh39aOJWA9U75Xqpd8r1TrmmUhflJXT63r-Zjzh8RP45LsD5HsAi5Nlj1Ml6nCwOPqLNegj-s_6_w6qS7w</recordid><startdate>20131201</startdate><enddate>20131201</enddate><creator>Rogina, A.</creator><creator>Ivanković, M.</creator><creator>Ivanković, H.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7SR</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>FR3</scope><scope>JG9</scope><scope>L7M</scope></search><sort><creationdate>20131201</creationdate><title>Preparation and characterization of nano-hydroxyapatite within chitosan matrix</title><author>Rogina, A. ; Ivanković, M. ; Ivanković, H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-748a8caf32ca8163bcfecb5661edd31175f3041ff7582f926e3d5e32a7a255273</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Acetic Acid - chemistry</topic><topic>Bones</topic><topic>Calcium Phosphates - chemistry</topic><topic>Chitosan</topic><topic>Chitosan - chemistry</topic><topic>Crystallization</topic><topic>Durapatite - chemistry</topic><topic>Glucose - chemistry</topic><topic>Hydrogen-Ion Concentration</topic><topic>Hydroxyapatite</topic><topic>In situ precipitation</topic><topic>Mathematical analysis</topic><topic>Microscopy, Electron, Transmission</topic><topic>Nano-hydroxyapatite</topic><topic>Nanocomposites</topic><topic>Nanocomposites - chemistry</topic><topic>Nanostructure</topic><topic>Phosphates</topic><topic>Spectroscopy, Fourier Transform Infrared</topic><topic>Temperature</topic><topic>Thermogravimetry</topic><topic>Tissue Engineering</topic><topic>Transmission electron microscopy</topic><topic>X-Ray Diffraction</topic><toplevel>online_resources</toplevel><creatorcontrib>Rogina, A.</creatorcontrib><creatorcontrib>Ivanković, M.</creatorcontrib><creatorcontrib>Ivanković, H.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Engineered Materials Abstracts</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Materials Science & Engineering C</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rogina, A.</au><au>Ivanković, M.</au><au>Ivanković, H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Preparation and characterization of nano-hydroxyapatite within chitosan matrix</atitle><jtitle>Materials Science & Engineering C</jtitle><addtitle>Mater Sci Eng C Mater Biol Appl</addtitle><date>2013-12-01</date><risdate>2013</risdate><volume>33</volume><issue>8</issue><spage>4539</spage><epage>4544</epage><pages>4539-4544</pages><issn>0928-4931</issn><eissn>1873-0191</eissn><abstract>Nano-composites that show some features of natural bone both in composition and in microstructure have been prepared by in situ precipitation method. Apatite phase has been prepared from cost-effective precursors (calcite and urea phosphate) within chitosan (CS) matrix dissolved in aqueous acetic acid solution. The compositional and morphological properties of composites were studied by means of Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD) thermogravimetric analysis (TGA) and transmission electron microscopy (TEM). Depending on the reaction conditions (temperature, reaction time, glucose addition and pH control) in addition to hydroxyapatite (HA) as a major phase, octacalcium hydrogen phosphate pentahydrate (OCP) and dicalcium phosphate anhydrate (DCPD) were formed as shown by XRD and FTIR. Crystallite lengths of precipitated HA estimated by Scherrer's equation were between 20 and 30nm. A fibrous morphology (~400nm) of HA observed by TEM indicates that HA nucleates on chitosan chains.
•Nano-hydroxyapatite (HA) was prepared by in situ precipitation within chitosan hydrogels and colloidal chitosan solution.•pH control was regulated by ammonia and urea degradation.•In situ urea degradation provides homogenous HA formation.•TEM imaging indicates fibrous morphology of HA with crystalline size of 400nm.•Glucose addition and temperature variation affect inorganic phase formation.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>24094157</pmid><doi>10.1016/j.msec.2013.07.008</doi><tpages>6</tpages></addata></record> |
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| subjects | Acetic Acid - chemistry Bones Calcium Phosphates - chemistry Chitosan Chitosan - chemistry Crystallization Durapatite - chemistry Glucose - chemistry Hydrogen-Ion Concentration Hydroxyapatite In situ precipitation Mathematical analysis Microscopy, Electron, Transmission Nano-hydroxyapatite Nanocomposites Nanocomposites - chemistry Nanostructure Phosphates Spectroscopy, Fourier Transform Infrared Temperature Thermogravimetry Tissue Engineering Transmission electron microscopy X-Ray Diffraction |
| title | Preparation and characterization of nano-hydroxyapatite within chitosan matrix |
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