Peculiarity in crystal packing of anti-HIV lectin actinohivin in complex with α(1-2)mannobiose

Previously, the anti‐HIV lectin actinohivin (AH) was cocrystallized with the target α(1–2)mannobiose (MB) in the apparent space group P213. However, three MB‐bound AH rotamers generated by ±120° rotations around the molecular pseudo‐threefold rotation axis are packed randomly in the unit cell accord...

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Veröffentlicht in:	Acta crystallographica. Section D, Biological crystallography. Biological crystallography., 2013-09, Vol.69 (9), p.1818-1825
Hauptverfasser:	Suzuki, Kaoru, Tsunoda, Masaru, Hoque, M. Mominul, Zhang, Fang, Jiang, Jiandong, Zhang, Xiaoxue, Ohbayashi, Naomi, Tanaka, Haruo, Takénaka, Akio
Format:	Artikel
Sprache:	eng
Schlagworte:	actinohivin anti-HIV lectin Bacterial Proteins - antagonists & inhibitors Bacterial Proteins - chemistry Binding Crystal structure Crystallization Crystallography, X-Ray Crystals Disorders high-mannose-type glycan HIV Fusion Inhibitors - chemistry Human immunodeficiency virus Lectins Mannans - chemistry Mannose-Binding Lectins - chemistry Mannosides - chemistry Peptides Random Allocation X-rays
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