Effects of exposure to low-level lead on spatial learning and memory and the expression of mGluR1, NMDA receptor in different developmental stages of rats
The effect of different periods of lead exposure on deficits of learning and memory is still unclear. In this study, we conduct in vivo experiment to investigate the critical stages when lead induced neurotoxicity in rats and its underlying mechanisms in some critical stages. Rats were exposed to 0....
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| Veröffentlicht in: | Toxicology and industrial health 2013-09, Vol.29 (8), p.686-696 |
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| creator | Wang, Xin-Mei Liu, Wen-Jun Zhang, Rong Zhou, Yi-Kai |
| description | The effect of different periods of lead exposure on deficits of learning and memory is still unclear. In this study, we conduct in vivo experiment to investigate the critical stages when lead induced neurotoxicity in rats and its underlying mechanisms in some critical stages. Rats were exposed to 0.2% mg/ml lead acetate solution via drinking water during gestation, lactation and ablactation periods. Behavior deficits were found in gestation and lactation. N-Methyl-d-aspartate (NMDA) receptor subunit 2A (NR2A) increased during gestation both in hippocampus and cerebral cortex compared to the control group; in all treatment groups NR2B decreased in hippocampus and in cerebral cortex during the lactation period. Meanwhile, in hippocampus metabotropic glutamate receptor 1 (mGluR1) decreased during gestation and lactation periods but increased during the ablactation period. These observations suggest that exposure to lead in gestation and lactation periods could cause neurobehavioral deficits which extend to adulthood, and lactation was a more sensitive period for lead exposure. Furthermore, the abnormal expression of NMDA receptor 2 (NMDAR 2) subunits and mGluR1 are likely to be associated with the impairment. |
| doi_str_mv | 10.1177/0748233712436641 |
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In this study, we conduct in vivo experiment to investigate the critical stages when lead induced neurotoxicity in rats and its underlying mechanisms in some critical stages. Rats were exposed to 0.2% mg/ml lead acetate solution via drinking water during gestation, lactation and ablactation periods. Behavior deficits were found in gestation and lactation. N-Methyl-d-aspartate (NMDA) receptor subunit 2A (NR2A) increased during gestation both in hippocampus and cerebral cortex compared to the control group; in all treatment groups NR2B decreased in hippocampus and in cerebral cortex during the lactation period. Meanwhile, in hippocampus metabotropic glutamate receptor 1 (mGluR1) decreased during gestation and lactation periods but increased during the ablactation period. These observations suggest that exposure to lead in gestation and lactation periods could cause neurobehavioral deficits which extend to adulthood, and lactation was a more sensitive period for lead exposure. Furthermore, the abnormal expression of NMDA receptor 2 (NMDAR 2) subunits and mGluR1 are likely to be associated with the impairment.</description><identifier>ISSN: 0748-2337</identifier><identifier>EISSN: 1477-0393</identifier><identifier>DOI: 10.1177/0748233712436641</identifier><identifier>PMID: 22362014</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Animals ; Biocompatibility ; Cerebral cortex ; Cerebral Cortex - drug effects ; Cerebral Cortex - metabolism ; Developmental stages ; Drinking water ; Environmental health ; Female ; Gene Expression Regulation ; Gestation ; Hippocampus ; Hippocampus - drug effects ; Hippocampus - metabolism ; Kinases ; Lactation - drug effects ; Lead (metal) ; Lead - toxicity ; Learning ; Male ; Maze Learning - drug effects ; Memory ; Memory - drug effects ; Memory Disorders - chemically induced ; Memory Disorders - pathology ; Nervous system ; Neurotoxicity ; Pregnancy ; Public health ; Rats ; Rats, Sprague-Dawley ; Receptors ; Receptors, Metabotropic Glutamate - genetics ; Receptors, Metabotropic Glutamate - metabolism ; Receptors, N-Methyl-D-Aspartate - genetics ; Receptors, N-Methyl-D-Aspartate - metabolism</subject><ispartof>Toxicology and industrial health, 2013-09, Vol.29 (8), p.686-696</ispartof><rights>The Author(s) 2012</rights><rights>SAGE Publications © Sep 2013</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c431t-9907c41be327187c76787e3d2d58ca5f6fa831c779f2010976e860a83a80694f3</citedby><cites>FETCH-LOGICAL-c431t-9907c41be327187c76787e3d2d58ca5f6fa831c779f2010976e860a83a80694f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/0748233712436641$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/0748233712436641$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,780,784,21817,27922,27923,43619,43620</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22362014$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Xin-Mei</creatorcontrib><creatorcontrib>Liu, Wen-Jun</creatorcontrib><creatorcontrib>Zhang, Rong</creatorcontrib><creatorcontrib>Zhou, Yi-Kai</creatorcontrib><title>Effects of exposure to low-level lead on spatial learning and memory and the expression of mGluR1, NMDA receptor in different developmental stages of rats</title><title>Toxicology and industrial health</title><addtitle>Toxicol Ind Health</addtitle><description>The effect of different periods of lead exposure on deficits of learning and memory is still unclear. In this study, we conduct in vivo experiment to investigate the critical stages when lead induced neurotoxicity in rats and its underlying mechanisms in some critical stages. Rats were exposed to 0.2% mg/ml lead acetate solution via drinking water during gestation, lactation and ablactation periods. Behavior deficits were found in gestation and lactation. N-Methyl-d-aspartate (NMDA) receptor subunit 2A (NR2A) increased during gestation both in hippocampus and cerebral cortex compared to the control group; in all treatment groups NR2B decreased in hippocampus and in cerebral cortex during the lactation period. Meanwhile, in hippocampus metabotropic glutamate receptor 1 (mGluR1) decreased during gestation and lactation periods but increased during the ablactation period. These observations suggest that exposure to lead in gestation and lactation periods could cause neurobehavioral deficits which extend to adulthood, and lactation was a more sensitive period for lead exposure. Furthermore, the abnormal expression of NMDA receptor 2 (NMDAR 2) subunits and mGluR1 are likely to be associated with the impairment.</description><subject>Animals</subject><subject>Biocompatibility</subject><subject>Cerebral cortex</subject><subject>Cerebral Cortex - drug effects</subject><subject>Cerebral Cortex - metabolism</subject><subject>Developmental stages</subject><subject>Drinking water</subject><subject>Environmental health</subject><subject>Female</subject><subject>Gene Expression Regulation</subject><subject>Gestation</subject><subject>Hippocampus</subject><subject>Hippocampus - drug effects</subject><subject>Hippocampus - metabolism</subject><subject>Kinases</subject><subject>Lactation - drug effects</subject><subject>Lead (metal)</subject><subject>Lead - toxicity</subject><subject>Learning</subject><subject>Male</subject><subject>Maze Learning - drug effects</subject><subject>Memory</subject><subject>Memory - drug effects</subject><subject>Memory Disorders - chemically induced</subject><subject>Memory Disorders - pathology</subject><subject>Nervous system</subject><subject>Neurotoxicity</subject><subject>Pregnancy</subject><subject>Public health</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Receptors</subject><subject>Receptors, Metabotropic Glutamate - genetics</subject><subject>Receptors, Metabotropic Glutamate - metabolism</subject><subject>Receptors, N-Methyl-D-Aspartate - genetics</subject><subject>Receptors, N-Methyl-D-Aspartate - metabolism</subject><issn>0748-2337</issn><issn>1477-0393</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkk9PFjEQxhuigRf0zsk08eKBhU7bbXePBBFNEBOj503pTnHJ7nZtu_z5Kn5au--LhJAYPXXa-c3zdNohZB_YIYDWR0zLiguhgUuhlIQtsgKpdcFELV6Q1ZIulvwO2Y3xmjGmVMm3yQ7nQnEGckV-nTqHNkXqHcW7ycc5IE2e9v626PEGe9qjaakfaZxM6sx6H8ZuvKJmbOmAgw_36zD9wEUhYIxdxrPecNbPX-GAXnx-f0wDWpySD7Qbadtl04Bjou1i4achx1k6JnOF66sEk-Ir8tKZPuLrh3WPfP9w-u3kY3H-5ezTyfF5YaWAVNQ101bCJQquodJWK11pFC1vy8qa0ilnKgFW69rlllmtFVaK5TNTMVVLJ_bIu43uFPzPGWNqhi5a7Hszop9jA0pDCVqA_DcqRc2FFEz8D8oqqaBc0LfP0Gs_hzH3vKZ4yQQsFNtQNvgYA7pmCt1gwn0DrFmmoXk-DbnkzYPwfDlg-1jw5_szUGyAmB_-ievfBH8DvIe6hw</recordid><startdate>20130901</startdate><enddate>20130901</enddate><creator>Wang, Xin-Mei</creator><creator>Liu, Wen-Jun</creator><creator>Zhang, Rong</creator><creator>Zhou, Yi-Kai</creator><general>SAGE Publications</general><general>Sage Publications Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QF</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7T2</scope><scope>7TA</scope><scope>7TB</scope><scope>7U5</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8BQ</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>F28</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H8D</scope><scope>H8G</scope><scope>HCIFZ</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9.</scope><scope>KR7</scope><scope>L6V</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>M0S</scope><scope>M1P</scope><scope>M7S</scope><scope>PATMY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>7X8</scope><scope>7TK</scope><scope>7U2</scope></search><sort><creationdate>20130901</creationdate><title>Effects of exposure to low-level lead on spatial learning and memory and the expression of mGluR1, NMDA receptor in different developmental stages of rats</title><author>Wang, Xin-Mei ; Liu, Wen-Jun ; Zhang, Rong ; Zhou, Yi-Kai</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c431t-9907c41be327187c76787e3d2d58ca5f6fa831c779f2010976e860a83a80694f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Animals</topic><topic>Biocompatibility</topic><topic>Cerebral cortex</topic><topic>Cerebral Cortex - 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Academic</collection><collection>Neurosciences Abstracts</collection><collection>Safety Science and Risk</collection><jtitle>Toxicology and industrial health</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Xin-Mei</au><au>Liu, Wen-Jun</au><au>Zhang, Rong</au><au>Zhou, Yi-Kai</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of exposure to low-level lead on spatial learning and memory and the expression of mGluR1, NMDA receptor in different developmental stages of rats</atitle><jtitle>Toxicology and industrial health</jtitle><addtitle>Toxicol Ind Health</addtitle><date>2013-09-01</date><risdate>2013</risdate><volume>29</volume><issue>8</issue><spage>686</spage><epage>696</epage><pages>686-696</pages><issn>0748-2337</issn><eissn>1477-0393</eissn><abstract>The effect of different periods of lead exposure on deficits of learning and memory is still unclear. In this study, we conduct in vivo experiment to investigate the critical stages when lead induced neurotoxicity in rats and its underlying mechanisms in some critical stages. Rats were exposed to 0.2% mg/ml lead acetate solution via drinking water during gestation, lactation and ablactation periods. Behavior deficits were found in gestation and lactation. N-Methyl-d-aspartate (NMDA) receptor subunit 2A (NR2A) increased during gestation both in hippocampus and cerebral cortex compared to the control group; in all treatment groups NR2B decreased in hippocampus and in cerebral cortex during the lactation period. Meanwhile, in hippocampus metabotropic glutamate receptor 1 (mGluR1) decreased during gestation and lactation periods but increased during the ablactation period. These observations suggest that exposure to lead in gestation and lactation periods could cause neurobehavioral deficits which extend to adulthood, and lactation was a more sensitive period for lead exposure. Furthermore, the abnormal expression of NMDA receptor 2 (NMDAR 2) subunits and mGluR1 are likely to be associated with the impairment.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>22362014</pmid><doi>10.1177/0748233712436641</doi><tpages>11</tpages></addata></record> |
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| subjects | Animals Biocompatibility Cerebral cortex Cerebral Cortex - drug effects Cerebral Cortex - metabolism Developmental stages Drinking water Environmental health Female Gene Expression Regulation Gestation Hippocampus Hippocampus - drug effects Hippocampus - metabolism Kinases Lactation - drug effects Lead (metal) Lead - toxicity Learning Male Maze Learning - drug effects Memory Memory - drug effects Memory Disorders - chemically induced Memory Disorders - pathology Nervous system Neurotoxicity Pregnancy Public health Rats Rats, Sprague-Dawley Receptors Receptors, Metabotropic Glutamate - genetics Receptors, Metabotropic Glutamate - metabolism Receptors, N-Methyl-D-Aspartate - genetics Receptors, N-Methyl-D-Aspartate - metabolism |
| title | Effects of exposure to low-level lead on spatial learning and memory and the expression of mGluR1, NMDA receptor in different developmental stages of rats |
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