Electrochemical control of cell death by reduction-induced intrinsic apoptosis and oxidation-induced necrosis on CoCrMo alloy in vitro

Abstract Electrochemical voltage shifts in metallic biomedical implants occur in-vivo due to a number of processes including mechanically assisted corrosion. These excursions may compromise the biocompatibility of metallic implants. Voltages can also be controlled to modulate cell function and fate....

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Veröffentlicht in:	Biomaterials 2012-09, Vol.33 (27), p.6295-6304
Hauptverfasser:	Haeri, Morteza, Wӧllert, Torsten, Langford, George M, Gilbert, Jeremy L
Format:	Artikel
Sprache:	eng
Schlagworte:	Advanced Basic Science Alloys - pharmacology Animals Apoptosis Apoptosis - drug effects Caspase 3 - metabolism Caspase 9 - metabolism Cell Adhesion - drug effects Cell death Cell Line Cell morphology Cell Nucleus Size - drug effects Cell Shape - drug effects Cell Survival - drug effects Cell viability Chromium Cobalt - pharmacology Cobalt alloy Corrosion Culture Media - chemistry Current density Cytoskeleton - drug effects Cytoskeleton - metabolism Dentistry Electric potential Electricity Electrochemistry - methods Fluorescence Ions Mice Models, Biological Necrosis - pathology Osteoblasts - cytology Osteoblasts - drug effects Osteoblasts - enzymology Osteoblasts - ultrastructure Oxidation-Reduction - drug effects Surgical implants Viability Vitallium - pharmacology Voltage
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