A soft supramolecular carrier with enhanced singlet oxygen photosensitizing properties
Herein we report the self-assembly of a supramolecular singlet oxygen photosensitizing system from an adamantane-functionalized, hexaanionic water-soluble zinc(ii) phthalocyanine (PC) and beta -cyclodextrin vesicles (CDV). Characterisation of the designed PC, which was synthesized by an asymmetric s...
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| Veröffentlicht in: | Soft matter 2013-01, Vol.9 (8), p.2453-2457 |
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| container_issue | 8 |
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| container_title | Soft matter |
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| creator | Voskuhl, Jens Kauscher, Ulrike Gruener, Malte Frisch, Hendrik Wibbeling, Birgit Strassert, Cristian A. Ravoo, Bart Jan |
| description | Herein we report the self-assembly of a supramolecular singlet oxygen photosensitizing system from an adamantane-functionalized, hexaanionic water-soluble zinc(ii) phthalocyanine (PC) and beta -cyclodextrin vesicles (CDV). Characterisation of the designed PC, which was synthesized by an asymmetric statistical condensation, was carried out by several analytical techniques such as MALDI-HRMS, NMR, IR, UV/vis as well as steady state and time resolved fluorescence spectroscopy. The influence of the docking of the PC to the CDVs on the PC photoluminescence as well as on the singlet oxygen photoproduction quantum yields was investigated. The results indicate that the host-guest interaction of the photosensitizer and the CDVs significantly prevents the formation of inactive aggregates, and enhances the photosensitizing ability of the PC. The supramolecular assembly constitutes a biocompatible photoactive platform for the design of phototherapeutic agents. |
| doi_str_mv | 10.1039/c2sm27353e |
| format | Article |
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| ispartof | Soft matter, 2013-01, Vol.9 (8), p.2453-2457 |
| issn | 1744-683X 1744-6848 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1671467876 |
| source | Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Carriers Fluorescence Mathematical analysis Photoproduction Polycarbonates Self assembly Singlet oxygen Time resolved |
| title | A soft supramolecular carrier with enhanced singlet oxygen photosensitizing properties |
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