Comparison of elastic scattering spectroscopy with histology in ex vivo prostate glands: potential application for optically guided biopsy and directed treatment
The false-negative rate of ultrasound-guided sextant prostate biopsy has been estimated to be as high as 35 %. A significant percentage (10–35 %) of these prostate cancers diagnosed at a second or later attempt are high grade and, therefore, potentially lethal. We discuss the feasibility for perform...
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| Veröffentlicht in: | Lasers in medical science 2013-09, Vol.28 (5), p.1323-1329 |
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| creator | A’Amar, O. M. Liou, L. Rodriguez-Diaz, E. De las Morenas, A. Bigio, I. J. |
| description | The false-negative rate of ultrasound-guided sextant prostate biopsy has been estimated to be as high as 35 %. A significant percentage (10–35 %) of these prostate cancers diagnosed at a second or later attempt are high grade and, therefore, potentially lethal. We discuss the feasibility for performing optically guided biopsy using elastic scattering spectroscopy (ESS) to reduce sampling errors and improve sensitivity. ESS measurements were performed on 42 prostate glands ex vivo and correlated with standard histopathological assessment. Sliced glands were examined with wavelength ranges of 330–760 nm. The ESS portable system used a new fiber-optic probe with integrated cutting tool, designed specifically for ex vivo pathology applications. ESS spectra were grouped by diagnosis from standard histopathological procedure and then classified using linear support vector machine. Preliminary data are encouraging. ESS data showed strong spectral trends correlating with the histopathological assignments. The classification results showed a sensitivity of 0.83 and specificity of 0.87 for distinguishing dysplastic prostatic tissue from benign prostatic tissue. Similar results were obtained for distinguishing dysplastic prostatic tissue from prostatitis with a sensitivity and specificity of 0.80 and 0.88, respectively. The negative predictive values obtained with ESS are better than those obtained with transrectal ultrasound (TRUS)-guided core-needle biopsy. |
| doi_str_mv | 10.1007/s10103-012-1245-6 |
| format | Article |
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ESS spectra were grouped by diagnosis from standard histopathological procedure and then classified using linear support vector machine. Preliminary data are encouraging. ESS data showed strong spectral trends correlating with the histopathological assignments. The classification results showed a sensitivity of 0.83 and specificity of 0.87 for distinguishing dysplastic prostatic tissue from benign prostatic tissue. Similar results were obtained for distinguishing dysplastic prostatic tissue from prostatitis with a sensitivity and specificity of 0.80 and 0.88, respectively. 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M.</creatorcontrib><creatorcontrib>Liou, L.</creatorcontrib><creatorcontrib>Rodriguez-Diaz, E.</creatorcontrib><creatorcontrib>De las Morenas, A.</creatorcontrib><creatorcontrib>Bigio, I. J.</creatorcontrib><title>Comparison of elastic scattering spectroscopy with histology in ex vivo prostate glands: potential application for optically guided biopsy and directed treatment</title><title>Lasers in medical science</title><addtitle>Lasers Med Sci</addtitle><addtitle>Lasers Med Sci</addtitle><description>The false-negative rate of ultrasound-guided sextant prostate biopsy has been estimated to be as high as 35 %. A significant percentage (10–35 %) of these prostate cancers diagnosed at a second or later attempt are high grade and, therefore, potentially lethal. We discuss the feasibility for performing optically guided biopsy using elastic scattering spectroscopy (ESS) to reduce sampling errors and improve sensitivity. ESS measurements were performed on 42 prostate glands ex vivo and correlated with standard histopathological assessment. Sliced glands were examined with wavelength ranges of 330–760 nm. The ESS portable system used a new fiber-optic probe with integrated cutting tool, designed specifically for ex vivo pathology applications. ESS spectra were grouped by diagnosis from standard histopathological procedure and then classified using linear support vector machine. Preliminary data are encouraging. ESS data showed strong spectral trends correlating with the histopathological assignments. The classification results showed a sensitivity of 0.83 and specificity of 0.87 for distinguishing dysplastic prostatic tissue from benign prostatic tissue. Similar results were obtained for distinguishing dysplastic prostatic tissue from prostatitis with a sensitivity and specificity of 0.80 and 0.88, respectively. The negative predictive values obtained with ESS are better than those obtained with transrectal ultrasound (TRUS)-guided core-needle biopsy.</description><subject>Biopsy</subject><subject>Comparative studies</subject><subject>Dentistry</subject><subject>Elastic scattering</subject><subject>Fiber optics</subject><subject>Humans</subject><subject>Image-Guided Biopsy - instrumentation</subject><subject>Image-Guided Biopsy - methods</subject><subject>Lasers</subject><subject>Male</subject><subject>Medical science</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Optical Devices</subject><subject>Optical Fibers</subject><subject>Optics</subject><subject>Original Article</subject><subject>Photonics</subject><subject>Prostate</subject><subject>Prostate - diagnostic imaging</subject><subject>Prostate - pathology</subject><subject>Prostate gland</subject><subject>Prostatic Hyperplasia - diagnosis</subject><subject>Prostatic Hyperplasia - pathology</subject><subject>Prostatic Neoplasms - diagnosis</subject><subject>Prostatic Neoplasms - pathology</subject><subject>Quantum Optics</subject><subject>Scattering</subject><subject>Scattering, Radiation</subject><subject>Spectroscopy</subject><subject>Spectrum Analysis</subject><subject>Support Vector Machine</subject><subject>Therapy</subject><subject>Ultrasonography</subject><issn>0268-8921</issn><issn>1435-604X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkkFrFTEUhYMo9rX6A9xIwI2b0dwkk8y4k4dWoeDGQndDXibzmjIziUmmOj_Hf9r7eFVEkLpKCN89h3NzCHkB7A0wpt9mYMBExYBXwGVdqUdkA1Lghcmrx2TDuGqqpuVwQk5zvmEMtALxlJxwwaVWSmzIz22Yokk-h5mGgbrR5OItzdaU4pKf9zRHZ0sK2Ya40u--XNNrn0sYw36lfqbuB731t4FGRIopju5HM_f5HY2huLl4M1IT4-hR0KPHEBINES3MOK50v_je9XTnQ8wrxTna-4R2-FaSM2VChWfkyWDG7J7fn2fk8uOHr9tP1cWX88_b9xeVlaIplXC6MczsmJS9BWhA9TsOquZiAFtzJwfeMta0gxaiBhBGGSa4rZXQrq1bK87I66MuJvm2uFy6yWfrRozjwpI7UBpkrWteP4xKKYTWHNr_QHmrJLQtQ_TVX-hNWNKMmZESEgDBBik4UhYXnpMbupj8ZNLaAesOreiOreiwFd2hFZ3CmZf3ystucv3viV81QIAfgRwPf-7SH9b_VL0DA5TD3w</recordid><startdate>20130901</startdate><enddate>20130901</enddate><creator>A’Amar, O. 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M.</au><au>Liou, L.</au><au>Rodriguez-Diaz, E.</au><au>De las Morenas, A.</au><au>Bigio, I. J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of elastic scattering spectroscopy with histology in ex vivo prostate glands: potential application for optically guided biopsy and directed treatment</atitle><jtitle>Lasers in medical science</jtitle><stitle>Lasers Med Sci</stitle><addtitle>Lasers Med Sci</addtitle><date>2013-09-01</date><risdate>2013</risdate><volume>28</volume><issue>5</issue><spage>1323</spage><epage>1329</epage><pages>1323-1329</pages><issn>0268-8921</issn><eissn>1435-604X</eissn><coden>LMSCEZ</coden><abstract>The false-negative rate of ultrasound-guided sextant prostate biopsy has been estimated to be as high as 35 %. A significant percentage (10–35 %) of these prostate cancers diagnosed at a second or later attempt are high grade and, therefore, potentially lethal. We discuss the feasibility for performing optically guided biopsy using elastic scattering spectroscopy (ESS) to reduce sampling errors and improve sensitivity. ESS measurements were performed on 42 prostate glands ex vivo and correlated with standard histopathological assessment. Sliced glands were examined with wavelength ranges of 330–760 nm. The ESS portable system used a new fiber-optic probe with integrated cutting tool, designed specifically for ex vivo pathology applications. ESS spectra were grouped by diagnosis from standard histopathological procedure and then classified using linear support vector machine. Preliminary data are encouraging. ESS data showed strong spectral trends correlating with the histopathological assignments. The classification results showed a sensitivity of 0.83 and specificity of 0.87 for distinguishing dysplastic prostatic tissue from benign prostatic tissue. Similar results were obtained for distinguishing dysplastic prostatic tissue from prostatitis with a sensitivity and specificity of 0.80 and 0.88, respectively. The negative predictive values obtained with ESS are better than those obtained with transrectal ultrasound (TRUS)-guided core-needle biopsy.</abstract><cop>London</cop><pub>Springer London</pub><pmid>23247663</pmid><doi>10.1007/s10103-012-1245-6</doi><tpages>7</tpages></addata></record> |
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| ispartof | Lasers in medical science, 2013-09, Vol.28 (5), p.1323-1329 |
| issn | 0268-8921 1435-604X |
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| subjects | Biopsy Comparative studies Dentistry Elastic scattering Fiber optics Humans Image-Guided Biopsy - instrumentation Image-Guided Biopsy - methods Lasers Male Medical science Medicine Medicine & Public Health Optical Devices Optical Fibers Optics Original Article Photonics Prostate Prostate - diagnostic imaging Prostate - pathology Prostate gland Prostatic Hyperplasia - diagnosis Prostatic Hyperplasia - pathology Prostatic Neoplasms - diagnosis Prostatic Neoplasms - pathology Quantum Optics Scattering Scattering, Radiation Spectroscopy Spectrum Analysis Support Vector Machine Therapy Ultrasonography |
| title | Comparison of elastic scattering spectroscopy with histology in ex vivo prostate glands: potential application for optically guided biopsy and directed treatment |
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