Photopolymerized hydrogel composites from poly(ethylene glycol) and hydroxyapatite for controlled protein delivery in vitro
The incorporation of hard particles into soft hydrogels can improve the mechanical properties and provide necessary bioactivity to the hydrogels for desired biomedical applications. Hydrogel composites containing hydroxyapatite (HA) are promising materials for orthopedic applications. In this study,...
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| Veröffentlicht in: | Journal of applied polymer science 2013-06, Vol.128 (6), p.3534-3539 |
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| creator | Lin, Genyao Tarasevich, Barbara |
| description | The incorporation of hard particles into soft hydrogels can improve the mechanical properties and provide necessary bioactivity to the hydrogels for desired biomedical applications. Hydrogel composites containing hydroxyapatite (HA) are promising materials for orthopedic applications. In this study, injectable poly(ethylene glycol) (PEG) hydrogel precursor solutions containing HA particles and model protein bovine serum albumin (BSA) were synthesized in situ by photopolymerization. In vitro BSA release properties from the hydrogel composites containing various amounts of HA were investigated and discussed. Fourier transform infrared spectroscopy and scanning electron microscopy were employed to investigate the interaction between HA and the hydrogel network and the morphology of the hydrogel composites. It is found that PEG hydrogel composites containing HA sustained the release of BSA for at least 5 days and the presence of HA slowed down BSA release. Photopolymerized hydrogel composites containing HA may find potential use as a drug delivery matrix for orthopedic tissue engineering. © 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013 |
| doi_str_mv | 10.1002/app.38560 |
| format | Article |
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Hydrogel composites containing hydroxyapatite (HA) are promising materials for orthopedic applications. In this study, injectable poly(ethylene glycol) (PEG) hydrogel precursor solutions containing HA particles and model protein bovine serum albumin (BSA) were synthesized in situ by photopolymerization. In vitro BSA release properties from the hydrogel composites containing various amounts of HA were investigated and discussed. Fourier transform infrared spectroscopy and scanning electron microscopy were employed to investigate the interaction between HA and the hydrogel network and the morphology of the hydrogel composites. It is found that PEG hydrogel composites containing HA sustained the release of BSA for at least 5 days and the presence of HA slowed down BSA release. Photopolymerized hydrogel composites containing HA may find potential use as a drug delivery matrix for orthopedic tissue engineering. © 2012 Wiley Periodicals, Inc. J. Appl. Polym. 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Appl. Polym. Sci</addtitle><description>The incorporation of hard particles into soft hydrogels can improve the mechanical properties and provide necessary bioactivity to the hydrogels for desired biomedical applications. Hydrogel composites containing hydroxyapatite (HA) are promising materials for orthopedic applications. In this study, injectable poly(ethylene glycol) (PEG) hydrogel precursor solutions containing HA particles and model protein bovine serum albumin (BSA) were synthesized in situ by photopolymerization. In vitro BSA release properties from the hydrogel composites containing various amounts of HA were investigated and discussed. Fourier transform infrared spectroscopy and scanning electron microscopy were employed to investigate the interaction between HA and the hydrogel network and the morphology of the hydrogel composites. It is found that PEG hydrogel composites containing HA sustained the release of BSA for at least 5 days and the presence of HA slowed down BSA release. Photopolymerized hydrogel composites containing HA may find potential use as a drug delivery matrix for orthopedic tissue engineering. © 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013</description><subject>Applied sciences</subject><subject>Biological and medical sciences</subject><subject>biomaterials</subject><subject>Composites</subject><subject>drug delivery systems</subject><subject>Exact sciences and technology</subject><subject>Forms of application and semi-finished materials</subject><subject>General pharmacology</subject><subject>Glycols</subject><subject>Hydrogels</subject><subject>Hydroxyapatite</subject><subject>In vitro testing</subject><subject>Materials science</subject><subject>Medical sciences</subject><subject>Orthopedics</subject><subject>Particulate composites</subject><subject>Pharmaceutical technology. Pharmaceutical industry</subject><subject>Pharmacology. Drug treatments</subject><subject>photopolymerization</subject><subject>Polymer industry, paints, wood</subject><subject>Polymers</subject><subject>Proteins</subject><subject>Reproduction</subject><subject>stimuli-sensitive hydrogels</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Technology of polymers</subject><subject>Technology. Biomaterials. Equipments</subject><issn>0021-8995</issn><issn>1097-4628</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNp1kU1v1DAQhi0EEkvhwD-IhJDaQ1pPnPjjWBXaIlV0BZU4WsaZdF2cONjZtmn_PF526aESJ1ua53k1o5eQ90APgdLqyIzjIZMNpy_IAqgSZc0r-ZIs8gxKqVTzmrxJ6YZSgIbyBXlcrsIUxuDnHqN7wLZYzW0M1-gLG_oxJDdhKroY-mID7eO0mj0OWFz72QZ_UJhhp9zPZjRTxosuxCwPUwze58AxhgndULTo3S3Gucj_W5enb8mrzviE73bvHrk6_Xx1cl5eXJ59OTm-KG3NgOatBQglbAedFIILySkYLlVlFavA1k1jmtbYpqq5qDphLApbIciftOXZZ3tkfxubF_m9xjTp3iWL3psBwzpp4AJyiBIyox-eoTdhHYe8nAYGUtUNBZWpgy1lY0gpYqfH6HoTZw1Ub1rQuQX9t4XMftwlmmSN76IZrEtPQrU5DSTL3NGWu3Me5_8H6uPl8l9yuTVcmvD-yTDxl-aCiUb_-Hqmv53Cd8U-VZqxP-gppnM</recordid><startdate>20130615</startdate><enddate>20130615</enddate><creator>Lin, Genyao</creator><creator>Tarasevich, Barbara</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8FD</scope><scope>JG9</scope></search><sort><creationdate>20130615</creationdate><title>Photopolymerized hydrogel composites from poly(ethylene glycol) and hydroxyapatite for controlled protein delivery in vitro</title><author>Lin, Genyao ; Tarasevich, Barbara</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4310-8971797cf1f877678601a6892c9321c455a5dac524672f7ace7c2e18b0d63103</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Applied sciences</topic><topic>Biological and medical sciences</topic><topic>biomaterials</topic><topic>Composites</topic><topic>drug delivery systems</topic><topic>Exact sciences and technology</topic><topic>Forms of application and semi-finished materials</topic><topic>General pharmacology</topic><topic>Glycols</topic><topic>Hydrogels</topic><topic>Hydroxyapatite</topic><topic>In vitro testing</topic><topic>Materials science</topic><topic>Medical sciences</topic><topic>Orthopedics</topic><topic>Particulate composites</topic><topic>Pharmaceutical technology. Pharmaceutical industry</topic><topic>Pharmacology. Drug treatments</topic><topic>photopolymerization</topic><topic>Polymer industry, paints, wood</topic><topic>Polymers</topic><topic>Proteins</topic><topic>Reproduction</topic><topic>stimuli-sensitive hydrogels</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Technology of polymers</topic><topic>Technology. Biomaterials. Equipments</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lin, Genyao</creatorcontrib><creatorcontrib>Tarasevich, Barbara</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><jtitle>Journal of applied polymer science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lin, Genyao</au><au>Tarasevich, Barbara</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Photopolymerized hydrogel composites from poly(ethylene glycol) and hydroxyapatite for controlled protein delivery in vitro</atitle><jtitle>Journal of applied polymer science</jtitle><addtitle>J. Appl. Polym. Sci</addtitle><date>2013-06-15</date><risdate>2013</risdate><volume>128</volume><issue>6</issue><spage>3534</spage><epage>3539</epage><pages>3534-3539</pages><issn>0021-8995</issn><eissn>1097-4628</eissn><coden>JAPNAB</coden><abstract>The incorporation of hard particles into soft hydrogels can improve the mechanical properties and provide necessary bioactivity to the hydrogels for desired biomedical applications. Hydrogel composites containing hydroxyapatite (HA) are promising materials for orthopedic applications. In this study, injectable poly(ethylene glycol) (PEG) hydrogel precursor solutions containing HA particles and model protein bovine serum albumin (BSA) were synthesized in situ by photopolymerization. In vitro BSA release properties from the hydrogel composites containing various amounts of HA were investigated and discussed. Fourier transform infrared spectroscopy and scanning electron microscopy were employed to investigate the interaction between HA and the hydrogel network and the morphology of the hydrogel composites. It is found that PEG hydrogel composites containing HA sustained the release of BSA for at least 5 days and the presence of HA slowed down BSA release. Photopolymerized hydrogel composites containing HA may find potential use as a drug delivery matrix for orthopedic tissue engineering. © 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><doi>10.1002/app.38560</doi><tpages>6</tpages></addata></record> |
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| subjects | Applied sciences Biological and medical sciences biomaterials Composites drug delivery systems Exact sciences and technology Forms of application and semi-finished materials General pharmacology Glycols Hydrogels Hydroxyapatite In vitro testing Materials science Medical sciences Orthopedics Particulate composites Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments photopolymerization Polymer industry, paints, wood Polymers Proteins Reproduction stimuli-sensitive hydrogels Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Technology of polymers Technology. Biomaterials. Equipments |
| title | Photopolymerized hydrogel composites from poly(ethylene glycol) and hydroxyapatite for controlled protein delivery in vitro |
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