Metal exposure and reproductive disorders in indigenous communities living along the Pilcomayo River, Bolivia
The Pilcomayo River is polluted by tailings and effluents from upstream mining activities, which contain high levels of metals. The Weenhayek live along this river and are likely to have elevated exposure. To assess whether the Weenhayek have increased risk of reproductive and developmental disorder...
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| Veröffentlicht in: | The Science of the total environment 2012-06, Vol.427-428, p.26-34 |
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| container_title | The Science of the total environment |
| container_volume | 427-428 |
| creator | Stassen, Marinke J.M. Preeker, N. Louise Ragas, Ad M.J. van de Ven, Max W.P.M. Smolders, Alfons J.P. Roeleveld, Nel |
| description | The Pilcomayo River is polluted by tailings and effluents from upstream mining activities, which contain high levels of metals. The Weenhayek live along this river and are likely to have elevated exposure.
To assess whether the Weenhayek have increased risk of reproductive and developmental disorders related to elevated metal exposure in comparison with a reference population.
We assessed reproductive and developmental outcomes, i.e. fertility, fetal loss, congenital anomalies, and walking onset by means of structured interviews. We sampled hair, water and fish to assess the relative exposure of the Weenhayek. Samples were analyzed for Pb and Cd with ICP-MS techniques.
The Weenhayek communities studied had a higher prevalence of small families (OR 2.7, 95% CI 1.3–6.0) and delayed walking onset (OR 2.7, 95% CI 1.4–5.1) than the reference population. Median Pb levels in Weenhayek hair were 2–5 times higher than in the reference population, while Cd levels were not elevated. In water and fish, both Pb and Cd levels were increased in the Weenhayek area.
We found indications for increased risks of small families and delayed walking onset among the Weenhayek living along the Pilcomayo River. Lactants form a high risk group for lead exposure.
► We assessed selected disorders and metal exposure in two comparable populations. ► Risks of small families and delayed walking onset were increased in the population with elevated lead levels in hair. ► The population with increased risks lives along a river with increased lead and cadmium levels in water and fish. |
| doi_str_mv | 10.1016/j.scitotenv.2012.03.072 |
| format | Article |
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To assess whether the Weenhayek have increased risk of reproductive and developmental disorders related to elevated metal exposure in comparison with a reference population.
We assessed reproductive and developmental outcomes, i.e. fertility, fetal loss, congenital anomalies, and walking onset by means of structured interviews. We sampled hair, water and fish to assess the relative exposure of the Weenhayek. Samples were analyzed for Pb and Cd with ICP-MS techniques.
The Weenhayek communities studied had a higher prevalence of small families (OR 2.7, 95% CI 1.3–6.0) and delayed walking onset (OR 2.7, 95% CI 1.4–5.1) than the reference population. Median Pb levels in Weenhayek hair were 2–5 times higher than in the reference population, while Cd levels were not elevated. In water and fish, both Pb and Cd levels were increased in the Weenhayek area.
We found indications for increased risks of small families and delayed walking onset among the Weenhayek living along the Pilcomayo River. Lactants form a high risk group for lead exposure.
► We assessed selected disorders and metal exposure in two comparable populations. ► Risks of small families and delayed walking onset were increased in the population with elevated lead levels in hair. ► The population with increased risks lives along a river with increased lead and cadmium levels in water and fish.</description><identifier>ISSN: 0048-9697</identifier><identifier>EISSN: 1879-1026</identifier><identifier>DOI: 10.1016/j.scitotenv.2012.03.072</identifier><identifier>PMID: 22575376</identifier><identifier>CODEN: STENDL</identifier><language>eng</language><publisher>Kidlington: Elsevier B.V</publisher><subject>Abnormalities, Drug-Induced - ethnology ; Adolescent ; Adult ; Animals ; Biological and medical sciences ; Bolivia - epidemiology ; Cadmium ; Cadmium - analysis ; Cadmium - toxicity ; Catfishes - physiology ; Chemical and industrial products toxicology. Toxic occupational diseases ; Communities ; Congenital anomalies ; Elevated ; Environmental Exposure ; Environmental Monitoring ; Epidemiological Monitoring ; Female ; Fertility ; Fertility - drug effects ; Fetal loss ; Fetal Mortality - ethnology ; Fish ; Food Contamination - analysis ; Freshwater ; Hair - chemistry ; Humans ; Indians, South American ; Infant ; Infant, Newborn ; Lead ; Lead (metal) ; Lead - analysis ; Lead - toxicity ; Male ; Mass Spectrometry ; Medical sciences ; Metals and various inorganic compounds ; Middle Aged ; Motor Skills Disorders - chemically induced ; Motor Skills Disorders - ethnology ; Risk ; Rivers ; Rivers - chemistry ; Toxicology ; Walking ; Walking onset ; Water Pollutants - analysis ; Water Pollutants - toxicity ; Young Adult</subject><ispartof>The Science of the total environment, 2012-06, Vol.427-428, p.26-34</ispartof><rights>2012 Elsevier B.V.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2012 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c516t-7cd9e40143efded05effbf84c97e56479046015a77ff05458ff6a710b3486a683</citedby><cites>FETCH-LOGICAL-c516t-7cd9e40143efded05effbf84c97e56479046015a77ff05458ff6a710b3486a683</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.scitotenv.2012.03.072$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,782,786,3552,27931,27932,46002</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25949570$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22575376$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Stassen, Marinke J.M.</creatorcontrib><creatorcontrib>Preeker, N. Louise</creatorcontrib><creatorcontrib>Ragas, Ad M.J.</creatorcontrib><creatorcontrib>van de Ven, Max W.P.M.</creatorcontrib><creatorcontrib>Smolders, Alfons J.P.</creatorcontrib><creatorcontrib>Roeleveld, Nel</creatorcontrib><title>Metal exposure and reproductive disorders in indigenous communities living along the Pilcomayo River, Bolivia</title><title>The Science of the total environment</title><addtitle>Sci Total Environ</addtitle><description>The Pilcomayo River is polluted by tailings and effluents from upstream mining activities, which contain high levels of metals. The Weenhayek live along this river and are likely to have elevated exposure.
To assess whether the Weenhayek have increased risk of reproductive and developmental disorders related to elevated metal exposure in comparison with a reference population.
We assessed reproductive and developmental outcomes, i.e. fertility, fetal loss, congenital anomalies, and walking onset by means of structured interviews. We sampled hair, water and fish to assess the relative exposure of the Weenhayek. Samples were analyzed for Pb and Cd with ICP-MS techniques.
The Weenhayek communities studied had a higher prevalence of small families (OR 2.7, 95% CI 1.3–6.0) and delayed walking onset (OR 2.7, 95% CI 1.4–5.1) than the reference population. Median Pb levels in Weenhayek hair were 2–5 times higher than in the reference population, while Cd levels were not elevated. In water and fish, both Pb and Cd levels were increased in the Weenhayek area.
We found indications for increased risks of small families and delayed walking onset among the Weenhayek living along the Pilcomayo River. Lactants form a high risk group for lead exposure.
► We assessed selected disorders and metal exposure in two comparable populations. ► Risks of small families and delayed walking onset were increased in the population with elevated lead levels in hair. ► The population with increased risks lives along a river with increased lead and cadmium levels in water and fish.</description><subject>Abnormalities, Drug-Induced - ethnology</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Bolivia - epidemiology</subject><subject>Cadmium</subject><subject>Cadmium - analysis</subject><subject>Cadmium - toxicity</subject><subject>Catfishes - physiology</subject><subject>Chemical and industrial products toxicology. 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Toxic occupational diseases</topic><topic>Communities</topic><topic>Congenital anomalies</topic><topic>Elevated</topic><topic>Environmental Exposure</topic><topic>Environmental Monitoring</topic><topic>Epidemiological Monitoring</topic><topic>Female</topic><topic>Fertility</topic><topic>Fertility - drug effects</topic><topic>Fetal loss</topic><topic>Fetal Mortality - ethnology</topic><topic>Fish</topic><topic>Food Contamination - analysis</topic><topic>Freshwater</topic><topic>Hair - chemistry</topic><topic>Humans</topic><topic>Indians, South American</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Lead</topic><topic>Lead (metal)</topic><topic>Lead - analysis</topic><topic>Lead - toxicity</topic><topic>Male</topic><topic>Mass Spectrometry</topic><topic>Medical sciences</topic><topic>Metals and various inorganic compounds</topic><topic>Middle Aged</topic><topic>Motor Skills Disorders - chemically induced</topic><topic>Motor Skills Disorders - ethnology</topic><topic>Risk</topic><topic>Rivers</topic><topic>Rivers - chemistry</topic><topic>Toxicology</topic><topic>Walking</topic><topic>Walking onset</topic><topic>Water Pollutants - analysis</topic><topic>Water Pollutants - toxicity</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Stassen, Marinke J.M.</creatorcontrib><creatorcontrib>Preeker, N. 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Louise</au><au>Ragas, Ad M.J.</au><au>van de Ven, Max W.P.M.</au><au>Smolders, Alfons J.P.</au><au>Roeleveld, Nel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Metal exposure and reproductive disorders in indigenous communities living along the Pilcomayo River, Bolivia</atitle><jtitle>The Science of the total environment</jtitle><addtitle>Sci Total Environ</addtitle><date>2012-06-15</date><risdate>2012</risdate><volume>427-428</volume><spage>26</spage><epage>34</epage><pages>26-34</pages><issn>0048-9697</issn><eissn>1879-1026</eissn><coden>STENDL</coden><abstract>The Pilcomayo River is polluted by tailings and effluents from upstream mining activities, which contain high levels of metals. The Weenhayek live along this river and are likely to have elevated exposure.
To assess whether the Weenhayek have increased risk of reproductive and developmental disorders related to elevated metal exposure in comparison with a reference population.
We assessed reproductive and developmental outcomes, i.e. fertility, fetal loss, congenital anomalies, and walking onset by means of structured interviews. We sampled hair, water and fish to assess the relative exposure of the Weenhayek. Samples were analyzed for Pb and Cd with ICP-MS techniques.
The Weenhayek communities studied had a higher prevalence of small families (OR 2.7, 95% CI 1.3–6.0) and delayed walking onset (OR 2.7, 95% CI 1.4–5.1) than the reference population. Median Pb levels in Weenhayek hair were 2–5 times higher than in the reference population, while Cd levels were not elevated. In water and fish, both Pb and Cd levels were increased in the Weenhayek area.
We found indications for increased risks of small families and delayed walking onset among the Weenhayek living along the Pilcomayo River. Lactants form a high risk group for lead exposure.
► We assessed selected disorders and metal exposure in two comparable populations. ► Risks of small families and delayed walking onset were increased in the population with elevated lead levels in hair. ► The population with increased risks lives along a river with increased lead and cadmium levels in water and fish.</abstract><cop>Kidlington</cop><pub>Elsevier B.V</pub><pmid>22575376</pmid><doi>10.1016/j.scitotenv.2012.03.072</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| issn | 0048-9697 1879-1026 |
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| subjects | Abnormalities, Drug-Induced - ethnology Adolescent Adult Animals Biological and medical sciences Bolivia - epidemiology Cadmium Cadmium - analysis Cadmium - toxicity Catfishes - physiology Chemical and industrial products toxicology. Toxic occupational diseases Communities Congenital anomalies Elevated Environmental Exposure Environmental Monitoring Epidemiological Monitoring Female Fertility Fertility - drug effects Fetal loss Fetal Mortality - ethnology Fish Food Contamination - analysis Freshwater Hair - chemistry Humans Indians, South American Infant Infant, Newborn Lead Lead (metal) Lead - analysis Lead - toxicity Male Mass Spectrometry Medical sciences Metals and various inorganic compounds Middle Aged Motor Skills Disorders - chemically induced Motor Skills Disorders - ethnology Risk Rivers Rivers - chemistry Toxicology Walking Walking onset Water Pollutants - analysis Water Pollutants - toxicity Young Adult |
| title | Metal exposure and reproductive disorders in indigenous communities living along the Pilcomayo River, Bolivia |
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