Effects of water molecules on binding kinetics of peptide receptor on a piezoelectric microcantilever
The use of highly selective reversible peptide receptors is essential for cantilever-based electronic nose systems. Here, we present the effects of water molecules on the binding kinetics of 2,4-dinitrotoluene (DNT) molecules with DNT selective peptide receptors linked with a tri(ethylene glycol)-ba...
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| Veröffentlicht in: | Applied physics letters 2012-12, Vol.101 (23) |
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| container_issue | 23 |
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| container_title | Applied physics letters |
| container_volume | 101 |
| creator | Hui Kim, Sang Kyoung Yoo, Yong Chae, Myung-Sic Yoon Kang, Ji Song Kim, Tae Seon Hwang, Kyo Hoon Lee, Jeong |
| description | The use of highly selective reversible peptide receptors is essential for cantilever-based electronic nose systems. Here, we present the effects of water molecules on the binding kinetics of 2,4-dinitrotoluene (DNT) molecules with DNT selective peptide receptors linked with a tri(ethylene glycol)-based (TEG) self-assembled monolayer (SAM) in a gas phase in a piezoelectric microcantilever sensor. We observed 1.5-times faster reaction kinetics in wet conditions compared with dry conditions. In a dissociation step, distinctive differences in the recovery time were observed in wet conditions, which could be attributed to water retention efficiency of TEG-linkers for the conformation of biomolecules. |
| doi_str_mv | 10.1063/1.4769969 |
| format | Article |
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Here, we present the effects of water molecules on the binding kinetics of 2,4-dinitrotoluene (DNT) molecules with DNT selective peptide receptors linked with a tri(ethylene glycol)-based (TEG) self-assembled monolayer (SAM) in a gas phase in a piezoelectric microcantilever sensor. We observed 1.5-times faster reaction kinetics in wet conditions compared with dry conditions. 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Here, we present the effects of water molecules on the binding kinetics of 2,4-dinitrotoluene (DNT) molecules with DNT selective peptide receptors linked with a tri(ethylene glycol)-based (TEG) self-assembled monolayer (SAM) in a gas phase in a piezoelectric microcantilever sensor. We observed 1.5-times faster reaction kinetics in wet conditions compared with dry conditions. In a dissociation step, distinctive differences in the recovery time were observed in wet conditions, which could be attributed to water retention efficiency of TEG-linkers for the conformation of biomolecules.</abstract><doi>10.1063/1.4769969</doi></addata></record> |
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| identifier | ISSN: 0003-6951 |
| ispartof | Applied physics letters, 2012-12, Vol.101 (23) |
| issn | 0003-6951 1077-3118 |
| language | eng |
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| source | AIP Journals Complete; AIP Digital Archive; Alma/SFX Local Collection |
| subjects | Acoustic microscopes Binding Biomolecules Drying Peptides Piezoelectricity Reaction kinetics Receptors |
| title | Effects of water molecules on binding kinetics of peptide receptor on a piezoelectric microcantilever |
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