Comparison of Diffusion Tensor Imaging-Derived Fractional Anisotropy in Multiple Centers for Identical Human Subjects
The fractional anisotropy (FA) is calculated by using diffusion tensor imaging (DTI) with multiple motion probing gradients (MPG). While FA has become a widely used tool to detect moderate changes in water diffusion in brain tissue, the measured value is sensitive to scan parameters (e.g. MPG-direct...
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| Veröffentlicht in: | Japanese Journal of Radiological Technology 2012/09/20, Vol.68(9), pp.1242-1249 |
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| creator | Saotome, Kousaku Ishimori, Yoshiyuki Isobe, Tomonori Satou, Eisuke Shinoda, Kazuya Ookubo, Jun Hirano, Yuuji Oosuka, Satoru Matsushita, Akira Miyamoto, Katsumi Sankai, Yoshiyuki |
| description | The fractional anisotropy (FA) is calculated by using diffusion tensor imaging (DTI) with multiple motion probing gradients (MPG). While FA has become a widely used tool to detect moderate changes in water diffusion in brain tissue, the measured value is sensitive to scan parameters (e.g. MPG-direction, signal to noise ratio, etc.). Therefore, it is paramount to address the reproducibility of DTI measurements among multiple centers. The purpose of this study was to assess the inter-center variability of FA. We studied five healthy volunteers who underwent DTI brain scanning three times at three different centers (I-III), each with a 1.5 T scanner having a different MPG-schema. Then, we compared the FA and eigenvalue from the three centers measured in seven brain regions: splenium of corpus callosum (CCs), genu of corpus callosum (CCg), putamen, posterior limb of internal capsule, cerebral peduncle, optic radiation, and middle cerebellar peduncle. At the CCs and CCg, there was a statistical difference (p |
| doi_str_mv | 10.6009/jjrt.2012_JSRT_68.9.1242 |
| format | Article |
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While FA has become a widely used tool to detect moderate changes in water diffusion in brain tissue, the measured value is sensitive to scan parameters (e.g. MPG-direction, signal to noise ratio, etc.). Therefore, it is paramount to address the reproducibility of DTI measurements among multiple centers. The purpose of this study was to assess the inter-center variability of FA. We studied five healthy volunteers who underwent DTI brain scanning three times at three different centers (I-III), each with a 1.5 T scanner having a different MPG-schema. Then, we compared the FA and eigenvalue from the three centers measured in seven brain regions: splenium of corpus callosum (CCs), genu of corpus callosum (CCg), putamen, posterior limb of internal capsule, cerebral peduncle, optic radiation, and middle cerebellar peduncle. At the CCs and CCg, there was a statistical difference (p<0.05) between center Iand center IIfor the same MPG-directions. Furthermore, at CCs and CCg, there was a statistical difference (p<0.05) between center II and center III for different MPG-directions. Conversely, no statistical differences were found between center I and center III for the different MPG-directions for all regions. These results indicate that the FA value was affected by the MPG-schema as well as by the MPG-directions.</description><identifier>ISSN: 0369-4305</identifier><identifier>EISSN: 1881-4883</identifier><identifier>DOI: 10.6009/jjrt.2012_JSRT_68.9.1242</identifier><identifier>PMID: 23001272</identifier><language>eng ; jpn</language><publisher>Japan: Japanese Society of Radiological Technology</publisher><subject>Anisotropy ; Brain ; Corpus Callosum ; Diffusion ; diffusion tensor imaging (DTI) ; Diffusion Tensor Imaging - methods ; Eigenvalues ; fractional anisotropy (FA) ; Humans ; Internal Capsule ; Mathematical analysis ; multicenter studies ; Putamen ; region of interest (ROI) ; Reproducibility ; Reproducibility of Results ; Tegmentum Mesencephali ; Tensors</subject><ispartof>Japanese Journal of Radiological Technology, 2012/09/20, Vol.68(9), pp.1242-1249</ispartof><rights>2012 Japanese Society of Radiological Technology</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4172-9aba954906c2aeaf453eec0977e07b648f55a3ff6bd5a5b0cc544ce316d486b93</citedby><cites>FETCH-LOGICAL-c4172-9aba954906c2aeaf453eec0977e07b648f55a3ff6bd5a5b0cc544ce316d486b93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4022,27921,27922,27923</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23001272$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Saotome, Kousaku</creatorcontrib><creatorcontrib>Ishimori, Yoshiyuki</creatorcontrib><creatorcontrib>Isobe, Tomonori</creatorcontrib><creatorcontrib>Satou, Eisuke</creatorcontrib><creatorcontrib>Shinoda, Kazuya</creatorcontrib><creatorcontrib>Ookubo, Jun</creatorcontrib><creatorcontrib>Hirano, Yuuji</creatorcontrib><creatorcontrib>Oosuka, Satoru</creatorcontrib><creatorcontrib>Matsushita, Akira</creatorcontrib><creatorcontrib>Miyamoto, Katsumi</creatorcontrib><creatorcontrib>Sankai, Yoshiyuki</creatorcontrib><title>Comparison of Diffusion Tensor Imaging-Derived Fractional Anisotropy in Multiple Centers for Identical Human Subjects</title><title>Japanese Journal of Radiological Technology</title><addtitle>Jpn. J. Radiol. Technol.</addtitle><description>The fractional anisotropy (FA) is calculated by using diffusion tensor imaging (DTI) with multiple motion probing gradients (MPG). While FA has become a widely used tool to detect moderate changes in water diffusion in brain tissue, the measured value is sensitive to scan parameters (e.g. MPG-direction, signal to noise ratio, etc.). Therefore, it is paramount to address the reproducibility of DTI measurements among multiple centers. The purpose of this study was to assess the inter-center variability of FA. We studied five healthy volunteers who underwent DTI brain scanning three times at three different centers (I-III), each with a 1.5 T scanner having a different MPG-schema. Then, we compared the FA and eigenvalue from the three centers measured in seven brain regions: splenium of corpus callosum (CCs), genu of corpus callosum (CCg), putamen, posterior limb of internal capsule, cerebral peduncle, optic radiation, and middle cerebellar peduncle. At the CCs and CCg, there was a statistical difference (p<0.05) between center Iand center IIfor the same MPG-directions. Furthermore, at CCs and CCg, there was a statistical difference (p<0.05) between center II and center III for different MPG-directions. Conversely, no statistical differences were found between center I and center III for the different MPG-directions for all regions. These results indicate that the FA value was affected by the MPG-schema as well as by the MPG-directions.</description><subject>Anisotropy</subject><subject>Brain</subject><subject>Corpus Callosum</subject><subject>Diffusion</subject><subject>diffusion tensor imaging (DTI)</subject><subject>Diffusion Tensor Imaging - methods</subject><subject>Eigenvalues</subject><subject>fractional anisotropy (FA)</subject><subject>Humans</subject><subject>Internal Capsule</subject><subject>Mathematical analysis</subject><subject>multicenter studies</subject><subject>Putamen</subject><subject>region of interest (ROI)</subject><subject>Reproducibility</subject><subject>Reproducibility of Results</subject><subject>Tegmentum Mesencephali</subject><subject>Tensors</subject><issn>0369-4305</issn><issn>1881-4883</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1O3DAURq2qVRkBr4C87CZT_ydZoqEUKlqkMqwtx7meepQ4qZ1U4u3rdGDEohIbW9c-517LH0KYkrUipP6838dpzQhl-tvDz61W1bpeUybYO7SiVUULUVX8PVoRrupCcCJP0HlKviHZzUdEfEQnjJPsl2yF5s3Qjyb6NAQ8OHzlnZuTz8UWQhoivu3NzoddcQXR_4EWX0djp3xvOnwZsjXFYXzCPuDvczf5sQO8gTBBTNgtdpsLbzN8M_cm4Ie52YOd0hn64EyX4Px5P0WP11-2m5vi7v7r7ebyrrCClqyoTWNqKWqiLDNgnJAcwJK6LIGUjRKVk9Jw51TTSiMbYq0UwgKnqhWVamp-ij4d-o5x-D1DmnTvk4WuMwGGOWmqSioIVZS8jVImGVdSqrdRUopSKUGWB1QH1MYhpQhOj9H3Jj5lSC9p6iVN_TpNXeslzaxePE-Zmx7ao_iSXQZ-HIB9mswOjoCJ-cs7OHT-1y8v_5lwBO0vEzUE_he9H7mo</recordid><startdate>2012</startdate><enddate>2012</enddate><creator>Saotome, Kousaku</creator><creator>Ishimori, Yoshiyuki</creator><creator>Isobe, Tomonori</creator><creator>Satou, Eisuke</creator><creator>Shinoda, Kazuya</creator><creator>Ookubo, Jun</creator><creator>Hirano, Yuuji</creator><creator>Oosuka, Satoru</creator><creator>Matsushita, Akira</creator><creator>Miyamoto, Katsumi</creator><creator>Sankai, Yoshiyuki</creator><general>Japanese Society of Radiological Technology</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7SC</scope><scope>7U5</scope><scope>JQ2</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope></search><sort><creationdate>2012</creationdate><title>Comparison of Diffusion Tensor Imaging-Derived Fractional Anisotropy in Multiple Centers for Identical Human Subjects</title><author>Saotome, Kousaku ; Ishimori, Yoshiyuki ; Isobe, Tomonori ; Satou, Eisuke ; Shinoda, Kazuya ; Ookubo, Jun ; Hirano, Yuuji ; Oosuka, Satoru ; Matsushita, Akira ; Miyamoto, Katsumi ; Sankai, Yoshiyuki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4172-9aba954906c2aeaf453eec0977e07b648f55a3ff6bd5a5b0cc544ce316d486b93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng ; jpn</language><creationdate>2012</creationdate><topic>Anisotropy</topic><topic>Brain</topic><topic>Corpus Callosum</topic><topic>Diffusion</topic><topic>diffusion tensor imaging (DTI)</topic><topic>Diffusion Tensor Imaging - methods</topic><topic>Eigenvalues</topic><topic>fractional anisotropy (FA)</topic><topic>Humans</topic><topic>Internal Capsule</topic><topic>Mathematical analysis</topic><topic>multicenter studies</topic><topic>Putamen</topic><topic>region of interest (ROI)</topic><topic>Reproducibility</topic><topic>Reproducibility of Results</topic><topic>Tegmentum Mesencephali</topic><topic>Tensors</topic><toplevel>online_resources</toplevel><creatorcontrib>Saotome, Kousaku</creatorcontrib><creatorcontrib>Ishimori, Yoshiyuki</creatorcontrib><creatorcontrib>Isobe, Tomonori</creatorcontrib><creatorcontrib>Satou, Eisuke</creatorcontrib><creatorcontrib>Shinoda, Kazuya</creatorcontrib><creatorcontrib>Ookubo, Jun</creatorcontrib><creatorcontrib>Hirano, Yuuji</creatorcontrib><creatorcontrib>Oosuka, Satoru</creatorcontrib><creatorcontrib>Matsushita, Akira</creatorcontrib><creatorcontrib>Miyamoto, Katsumi</creatorcontrib><creatorcontrib>Sankai, Yoshiyuki</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>ProQuest Computer Science Collection</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><jtitle>Japanese Journal of Radiological Technology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Saotome, Kousaku</au><au>Ishimori, Yoshiyuki</au><au>Isobe, Tomonori</au><au>Satou, Eisuke</au><au>Shinoda, Kazuya</au><au>Ookubo, Jun</au><au>Hirano, Yuuji</au><au>Oosuka, Satoru</au><au>Matsushita, Akira</au><au>Miyamoto, Katsumi</au><au>Sankai, Yoshiyuki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of Diffusion Tensor Imaging-Derived Fractional Anisotropy in Multiple Centers for Identical Human Subjects</atitle><jtitle>Japanese Journal of Radiological Technology</jtitle><addtitle>Jpn. 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Then, we compared the FA and eigenvalue from the three centers measured in seven brain regions: splenium of corpus callosum (CCs), genu of corpus callosum (CCg), putamen, posterior limb of internal capsule, cerebral peduncle, optic radiation, and middle cerebellar peduncle. At the CCs and CCg, there was a statistical difference (p<0.05) between center Iand center IIfor the same MPG-directions. Furthermore, at CCs and CCg, there was a statistical difference (p<0.05) between center II and center III for different MPG-directions. Conversely, no statistical differences were found between center I and center III for the different MPG-directions for all regions. These results indicate that the FA value was affected by the MPG-schema as well as by the MPG-directions.</abstract><cop>Japan</cop><pub>Japanese Society of Radiological Technology</pub><pmid>23001272</pmid><doi>10.6009/jjrt.2012_JSRT_68.9.1242</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Anisotropy Brain Corpus Callosum Diffusion diffusion tensor imaging (DTI) Diffusion Tensor Imaging - methods Eigenvalues fractional anisotropy (FA) Humans Internal Capsule Mathematical analysis multicenter studies Putamen region of interest (ROI) Reproducibility Reproducibility of Results Tegmentum Mesencephali Tensors |
| title | Comparison of Diffusion Tensor Imaging-Derived Fractional Anisotropy in Multiple Centers for Identical Human Subjects |
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