Synthesis of biodegradable material poly(lactic acid‐co‐aspartic acid) via direct melt polycondensation and its characterization
Directly starting from L‐lactic acid (LA) and L‐aspartic acid (Asp), biodegradable material poly(lactic acid‐co‐aspartic acid) [P(LA‐co‐Asp)] was synthesized via melt polycondensation. The synthetic conditions, including type and dosage of catalyst, temperature, and time of copolymerization, and inf...
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| Veröffentlicht in: | Journal of applied polymer science 2011-09, Vol.121 (6), p.3662-3668 |
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| creator | Ye, Rui‐Rong Wang, Zhao‐Yang Wang, Qun‐Fang Yang, Kai Luo, Shi‐He |
| description | Directly starting from L‐lactic acid (LA) and L‐aspartic acid (Asp), biodegradable material poly(lactic acid‐co‐aspartic acid) [P(LA‐co‐Asp)] was synthesized via melt polycondensation. The synthetic conditions, including type and dosage of catalyst, temperature, and time of copolymerization, and influence of molar feed ratio were discussed. The structure and properties of the copolymer were systematically characterized with FTIR, 1H‐NMR, GPC, DSC, and XRD. With the increase of Asp in the feed, [η] and Mw decreased, and the crystallinity of the copolymer disappeared gradually. Compared to the homopolymer, poly(L‐lactic acid) synthesized via melt polycondensation and the copolymer P(LA‐co‐Asp) had a higher glass‐transition temperature (Tg). The copolymer P(LA‐co‐Asp) with Mw of 4400–24300 Da was obtained, which could meet the demand as a drug‐delivery carrier material. Compared to the ring‐opening polymerization of the cyclic intermediates, including lactide, the novel direct copolycondensation method was a cheap and practical method for the synthesis of copolymer P(LA‐co‐Asp) as biomedical materials. © 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2011 |
| doi_str_mv | 10.1002/app.34168 |
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The synthetic conditions, including type and dosage of catalyst, temperature, and time of copolymerization, and influence of molar feed ratio were discussed. The structure and properties of the copolymer were systematically characterized with FTIR, 1H‐NMR, GPC, DSC, and XRD. With the increase of Asp in the feed, [η] and Mw decreased, and the crystallinity of the copolymer disappeared gradually. Compared to the homopolymer, poly(L‐lactic acid) synthesized via melt polycondensation and the copolymer P(LA‐co‐Asp) had a higher glass‐transition temperature (Tg). The copolymer P(LA‐co‐Asp) with Mw of 4400–24300 Da was obtained, which could meet the demand as a drug‐delivery carrier material. Compared to the ring‐opening polymerization of the cyclic intermediates, including lactide, the novel direct copolycondensation method was a cheap and practical method for the synthesis of copolymer P(LA‐co‐Asp) as biomedical materials. © 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2011</description><identifier>ISSN: 0021-8995</identifier><identifier>ISSN: 1097-4628</identifier><identifier>EISSN: 1097-4628</identifier><identifier>DOI: 10.1002/app.34168</identifier><identifier>CODEN: JAPNAB</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Acids ; Applied sciences ; Biodegradability ; biodegradable ; Biodegradable materials ; Biological and medical sciences ; Biomedical materials ; Copolymerization ; Copolymers ; Crystallinity ; Differential scanning calorimetry ; Exact sciences and technology ; Materials science ; Medical sciences ; melt ; Melts ; Organic polymers ; Physicochemistry of polymers ; polycondensation ; Polymers ; Polymers with particular properties ; Preparation, kinetics, thermodynamics, mechanism and catalysts ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Synthesis ; Technology. Biomaterials. Equipments</subject><ispartof>Journal of applied polymer science, 2011-09, Vol.121 (6), p.3662-3668</ispartof><rights>Copyright © 2011 Wiley Periodicals, Inc.</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3938-fc83b813d34782d6bb2f03f9b2561daac7029273bed297c7e543ddc0cccfd6e83</citedby><cites>FETCH-LOGICAL-c3938-fc83b813d34782d6bb2f03f9b2561daac7029273bed297c7e543ddc0cccfd6e83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fapp.34168$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fapp.34168$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24326072$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>Ye, Rui‐Rong</creatorcontrib><creatorcontrib>Wang, Zhao‐Yang</creatorcontrib><creatorcontrib>Wang, Qun‐Fang</creatorcontrib><creatorcontrib>Yang, Kai</creatorcontrib><creatorcontrib>Luo, Shi‐He</creatorcontrib><title>Synthesis of biodegradable material poly(lactic acid‐co‐aspartic acid) via direct melt polycondensation and its characterization</title><title>Journal of applied polymer science</title><description>Directly starting from L‐lactic acid (LA) and L‐aspartic acid (Asp), biodegradable material poly(lactic acid‐co‐aspartic acid) [P(LA‐co‐Asp)] was synthesized via melt polycondensation. The synthetic conditions, including type and dosage of catalyst, temperature, and time of copolymerization, and influence of molar feed ratio were discussed. The structure and properties of the copolymer were systematically characterized with FTIR, 1H‐NMR, GPC, DSC, and XRD. With the increase of Asp in the feed, [η] and Mw decreased, and the crystallinity of the copolymer disappeared gradually. Compared to the homopolymer, poly(L‐lactic acid) synthesized via melt polycondensation and the copolymer P(LA‐co‐Asp) had a higher glass‐transition temperature (Tg). The copolymer P(LA‐co‐Asp) with Mw of 4400–24300 Da was obtained, which could meet the demand as a drug‐delivery carrier material. Compared to the ring‐opening polymerization of the cyclic intermediates, including lactide, the novel direct copolycondensation method was a cheap and practical method for the synthesis of copolymer P(LA‐co‐Asp) as biomedical materials. © 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2011</description><subject>Acids</subject><subject>Applied sciences</subject><subject>Biodegradability</subject><subject>biodegradable</subject><subject>Biodegradable materials</subject><subject>Biological and medical sciences</subject><subject>Biomedical materials</subject><subject>Copolymerization</subject><subject>Copolymers</subject><subject>Crystallinity</subject><subject>Differential scanning calorimetry</subject><subject>Exact sciences and technology</subject><subject>Materials science</subject><subject>Medical sciences</subject><subject>melt</subject><subject>Melts</subject><subject>Organic polymers</subject><subject>Physicochemistry of polymers</subject><subject>polycondensation</subject><subject>Polymers</subject><subject>Polymers with particular properties</subject><subject>Preparation, kinetics, thermodynamics, mechanism and catalysts</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Synthesis</subject><subject>Technology. Biomaterials. Equipments</subject><issn>0021-8995</issn><issn>1097-4628</issn><issn>1097-4628</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><recordid>eNqFkc9KHTEUh0Op0Fvtom8QkIIuRvNnJsksRWwtCBWq6-HMSUYjuZNpMrfluuqiD-Az-iTGe20XhdJNDuR85zscfoS85-yIMyaOYZqOZM2VeUUWnLW6qpUwr8mi9Hhl2rZ5Q97mfMcY5w1TC_Lr63qcb132mcaB9j5ad5PAQh8cXcLskodApxjWBwFw9kgBvX38-YCxPJAnSL8_D-l3D9T65HCmSxfmzRjG0boxw-zjSGG01M-Z4i2kYivy-01jj-wMELJ791J3yfXHs6vT8-riy6fPpycXFcpWmmpAI3vDpZW1NsKqvhcDk0Pbi0ZxC4CaiVZo2TsrWo3aNbW0FhkiDlY5I3fJwdY7pfht5fLcLX1GFwKMLq5yx5XmstFSq_-jTAijdc1FQff_Qu_iKo3lkI43JQkhVKsLdbilMMWckxu6KfklpHVRdc_RdSW6bhNdYT-8GCEjhCHBiD7_GRC1FIrp583HW-6HD279b2F3cnm5NT8Bl4erZw</recordid><startdate>20110915</startdate><enddate>20110915</enddate><creator>Ye, Rui‐Rong</creator><creator>Wang, Zhao‐Yang</creator><creator>Wang, Qun‐Fang</creator><creator>Yang, Kai</creator><creator>Luo, Shi‐He</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley</general><general>Wiley Subscription Services, Inc</general><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8FD</scope><scope>JG9</scope><scope>7QO</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>20110915</creationdate><title>Synthesis of biodegradable material poly(lactic acid‐co‐aspartic acid) via direct melt polycondensation and its characterization</title><author>Ye, Rui‐Rong ; Wang, Zhao‐Yang ; Wang, Qun‐Fang ; Yang, Kai ; Luo, Shi‐He</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3938-fc83b813d34782d6bb2f03f9b2561daac7029273bed297c7e543ddc0cccfd6e83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Acids</topic><topic>Applied sciences</topic><topic>Biodegradability</topic><topic>biodegradable</topic><topic>Biodegradable materials</topic><topic>Biological and medical sciences</topic><topic>Biomedical materials</topic><topic>Copolymerization</topic><topic>Copolymers</topic><topic>Crystallinity</topic><topic>Differential scanning calorimetry</topic><topic>Exact sciences and technology</topic><topic>Materials science</topic><topic>Medical sciences</topic><topic>melt</topic><topic>Melts</topic><topic>Organic polymers</topic><topic>Physicochemistry of polymers</topic><topic>polycondensation</topic><topic>Polymers</topic><topic>Polymers with particular properties</topic><topic>Preparation, kinetics, thermodynamics, mechanism and catalysts</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Synthesis</topic><topic>Technology. Biomaterials. Equipments</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ye, Rui‐Rong</creatorcontrib><creatorcontrib>Wang, Zhao‐Yang</creatorcontrib><creatorcontrib>Wang, Qun‐Fang</creatorcontrib><creatorcontrib>Yang, Kai</creatorcontrib><creatorcontrib>Luo, Shi‐He</creatorcontrib><collection>Pascal-Francis</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>Biotechnology Research Abstracts</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Journal of applied polymer science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ye, Rui‐Rong</au><au>Wang, Zhao‐Yang</au><au>Wang, Qun‐Fang</au><au>Yang, Kai</au><au>Luo, Shi‐He</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synthesis of biodegradable material poly(lactic acid‐co‐aspartic acid) via direct melt polycondensation and its characterization</atitle><jtitle>Journal of applied polymer science</jtitle><date>2011-09-15</date><risdate>2011</risdate><volume>121</volume><issue>6</issue><spage>3662</spage><epage>3668</epage><pages>3662-3668</pages><issn>0021-8995</issn><issn>1097-4628</issn><eissn>1097-4628</eissn><coden>JAPNAB</coden><abstract>Directly starting from L‐lactic acid (LA) and L‐aspartic acid (Asp), biodegradable material poly(lactic acid‐co‐aspartic acid) [P(LA‐co‐Asp)] was synthesized via melt polycondensation. The synthetic conditions, including type and dosage of catalyst, temperature, and time of copolymerization, and influence of molar feed ratio were discussed. The structure and properties of the copolymer were systematically characterized with FTIR, 1H‐NMR, GPC, DSC, and XRD. With the increase of Asp in the feed, [η] and Mw decreased, and the crystallinity of the copolymer disappeared gradually. Compared to the homopolymer, poly(L‐lactic acid) synthesized via melt polycondensation and the copolymer P(LA‐co‐Asp) had a higher glass‐transition temperature (Tg). The copolymer P(LA‐co‐Asp) with Mw of 4400–24300 Da was obtained, which could meet the demand as a drug‐delivery carrier material. Compared to the ring‐opening polymerization of the cyclic intermediates, including lactide, the novel direct copolycondensation method was a cheap and practical method for the synthesis of copolymer P(LA‐co‐Asp) as biomedical materials. © 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2011</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><doi>10.1002/app.34168</doi><tpages>7</tpages></addata></record> |
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| subjects | Acids Applied sciences Biodegradability biodegradable Biodegradable materials Biological and medical sciences Biomedical materials Copolymerization Copolymers Crystallinity Differential scanning calorimetry Exact sciences and technology Materials science Medical sciences melt Melts Organic polymers Physicochemistry of polymers polycondensation Polymers Polymers with particular properties Preparation, kinetics, thermodynamics, mechanism and catalysts Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Synthesis Technology. Biomaterials. Equipments |
| title | Synthesis of biodegradable material poly(lactic acid‐co‐aspartic acid) via direct melt polycondensation and its characterization |
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