Immunocytokines: a novel class of potent armed antibodies

Several cytokines have been investigated in clinical trials, based on their potent therapeutic activity observed in animal models of cancer and other diseases. However, substantial toxicities are often reported at low doses, thus preventing escalation to therapeutically active regimens. The use of r...

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Veröffentlicht in:	Drug discovery today 2012-06, Vol.17 (11-12), p.583-590
Hauptverfasser:	Pasche, Nadine, Neri, Dario
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Antibodies, Monoclonal - immunology Antibodies, Monoclonal - pharmacokinetics Antigens Antigens, Neoplasm - immunology Antineoplastic Agents - administration & dosage Antineoplastic Agents - immunology Antineoplastic Agents - pharmacokinetics Antineoplastic Agents - therapeutic use Biocompatibility Biological and medical sciences Clinical Trials as Topic Cytokines Cytokines - administration & dosage Cytokines - immunology Cytokines - pharmacokinetics Cytokines - therapeutic use Diseases Dose-Response Relationship, Drug Drug Delivery Systems - methods Drug Discovery Drug Evaluation, Preclinical Fragments General pharmacology Humans Immunoglobulin Fab Fragments - immunology Medical sciences Molecular Targeted Therapy Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Recombinant Recombinant Fusion Proteins - administration & dosage Recombinant Fusion Proteins - immunology Recombinant Fusion Proteins - pharmacokinetics Recombinant Fusion Proteins - therapeutic use Tissue Distribution Toxicity
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