Metaxalone estimation in biological matrix using high-throughput LC–MS/MS bioanalytical method

► High-throughput bioanalytical method was developed and validated adhering to global regulatory norms. ► We examined metaxalone in blood, plasma and in hemolyzed/lipemic plasma for effect of matrix component interference. ► Achieved mean recovery >78% for both metaxalone and its internal standar...

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Veröffentlicht in:	Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Analytical technologies in the biomedical and life sciences, 2012-08, Vol.902, p.132-136
Hauptverfasser:	Goswami, Dipanjan, Saha, Arabinda, Gurule, Sanjay, Khuroo, Arshad, Monif, Tausif, Vats, Poonam
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult ammonium acetate analgesia Blood blood plasma Chromatography Chromatography, Liquid - methods clinical trials drug formulations Drug Stability Drugs Extraction Flow rate Hemolysis High-Throughput Screening Assays - methods Humans Hyperlipidemias - blood Ionization LC–MS/MS Linear Models Male Matrix stability Metaxalone Method development Method validation monitoring Muscle relaxants oral administration Oxazolidinones - blood Oxazolidinones - chemistry particle size Reproducibility of Results Sensitivity and Specificity skeletal muscle Solid Phase Extraction spectral analysis spectrometers Stability Tandem Mass Spectrometry - methods
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