Bupivacaine-enhanced small intestinal submucosa biomaterial as a hernia repair device

Management of post-surgical pain following herniorrhaphy remains a clinical challenge and novel methods to deliver analgesic compounds could be of great benefit. Because there is great interest in the use of natural biomaterials for hernia repair, we investigated the biocompatibility of a natural bi...

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Veröffentlicht in:	Journal of biomaterials applications 2012-08, Vol.27 (2), p.231-237
Hauptverfasser:	Suckow, Mark A, Wolter, William R, Fecteau, Chris, LaBadie-Suckow, Susan M, Johnson, Chad
Format:	Artikel
Sprache:	eng
Schlagworte:	Abdominal Wall - surgery Absorbable Implants Adhesion Anesthetics, Local - administration & dosage Anesthetics, Local - blood Anesthetics, Local - therapeutic use Animals Biocompatible Materials - chemistry Biomaterials Biomedical materials Bupivacaine Bupivacaine - administration & dosage Bupivacaine - blood Bupivacaine - therapeutic use Drug Delivery Systems - instrumentation Herniorrhaphy - instrumentation Implantation Intestinal Mucosa - chemistry Intestine, Small - chemistry Lactic Acid - chemistry Male Pain, Postoperative - drug therapy Polyglycolic Acid - chemistry Rats Rats, Sprague-Dawley Repair Stress, Mechanical Surgical implants Swine
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