Bupivacaine-enhanced small intestinal submucosa biomaterial as a hernia repair device

Management of post-surgical pain following herniorrhaphy remains a clinical challenge and novel methods to deliver analgesic compounds could be of great benefit. Because there is great interest in the use of natural biomaterials for hernia repair, we investigated the biocompatibility of a natural bi...

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Veröffentlicht in:Journal of biomaterials applications 2012-08, Vol.27 (2), p.231-237
Hauptverfasser: Suckow, Mark A, Wolter, William R, Fecteau, Chris, LaBadie-Suckow, Susan M, Johnson, Chad
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container_end_page 237
container_issue 2
container_start_page 231
container_title Journal of biomaterials applications
container_volume 27
creator Suckow, Mark A
Wolter, William R
Fecteau, Chris
LaBadie-Suckow, Susan M
Johnson, Chad
description Management of post-surgical pain following herniorrhaphy remains a clinical challenge and novel methods to deliver analgesic compounds could be of great benefit. Because there is great interest in the use of natural biomaterials for hernia repair, we investigated the biocompatibility of a natural biomaterial, porcine small intestinal submucosa (SIS), which was impregnated with bupivacaine (SIS-B) via immersion in a solution of poly(lactic-co-glycolic acid) (PLGA). Groups of Sprague Dawley rats underwent surgical creation of a ventral abdominal wall defect with subsequent repair using either SIS or SIS-B. Analysis of serial blood samples showed peak bupivacaine levels (83 ng/mL) were achieved 16 h after implantation of SIS-B. One month after surgery, the rats were euthanized and implant sites harvested for mechanical strength testing and histological analysis. At the time of necropsy, adhesion extent and tenacity was greater in SIS-B rats, with 90% of SIS-B rats have adhesion to the implant site compared to only 75% of SIS rats. Microscopically, SIS implant sites were characterized by small amounts of residual SIS surrounded by mild-to-moderate chronic inflammation. In contrast, rats treated with SIS-B, residual SIS-B was surrounded by a ring of acute inflammatory cells and an outer ring of chronic inflammatory cells, possibly due to bupivacaine or residual PLGA. Mechanical strength testing of the harvested implant sites showed no significant (p ≤ 0.05) difference between SIS and SIS-B implants. In summary, bupivacaine is readily elaborated from SIS-B; and impregnation of SIS with bupivacaine does not substantially alter the biocompatibility of the biomaterial or its mechanical strength following implantation.
doi_str_mv 10.1177/0885328211406298
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Because there is great interest in the use of natural biomaterials for hernia repair, we investigated the biocompatibility of a natural biomaterial, porcine small intestinal submucosa (SIS), which was impregnated with bupivacaine (SIS-B) via immersion in a solution of poly(lactic-co-glycolic acid) (PLGA). Groups of Sprague Dawley rats underwent surgical creation of a ventral abdominal wall defect with subsequent repair using either SIS or SIS-B. Analysis of serial blood samples showed peak bupivacaine levels (83 ng/mL) were achieved 16 h after implantation of SIS-B. One month after surgery, the rats were euthanized and implant sites harvested for mechanical strength testing and histological analysis. At the time of necropsy, adhesion extent and tenacity was greater in SIS-B rats, with 90% of SIS-B rats have adhesion to the implant site compared to only 75% of SIS rats. 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Because there is great interest in the use of natural biomaterials for hernia repair, we investigated the biocompatibility of a natural biomaterial, porcine small intestinal submucosa (SIS), which was impregnated with bupivacaine (SIS-B) via immersion in a solution of poly(lactic-co-glycolic acid) (PLGA). Groups of Sprague Dawley rats underwent surgical creation of a ventral abdominal wall defect with subsequent repair using either SIS or SIS-B. Analysis of serial blood samples showed peak bupivacaine levels (83 ng/mL) were achieved 16 h after implantation of SIS-B. One month after surgery, the rats were euthanized and implant sites harvested for mechanical strength testing and histological analysis. At the time of necropsy, adhesion extent and tenacity was greater in SIS-B rats, with 90% of SIS-B rats have adhesion to the implant site compared to only 75% of SIS rats. 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subjects Abdominal Wall - surgery
Absorbable Implants
Adhesion
Anesthetics, Local - administration & dosage
Anesthetics, Local - blood
Anesthetics, Local - therapeutic use
Animals
Biocompatible Materials - chemistry
Biomaterials
Biomedical materials
Bupivacaine
Bupivacaine - administration & dosage
Bupivacaine - blood
Bupivacaine - therapeutic use
Drug Delivery Systems - instrumentation
Herniorrhaphy - instrumentation
Implantation
Intestinal Mucosa - chemistry
Intestine, Small - chemistry
Lactic Acid - chemistry
Male
Pain, Postoperative - drug therapy
Polyglycolic Acid - chemistry
Rats
Rats, Sprague-Dawley
Repair
Stress, Mechanical
Surgical implants
Swine
title Bupivacaine-enhanced small intestinal submucosa biomaterial as a hernia repair device
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