Synthesis and release profile analysis of thermo-sensitive albumin hydrogels
Novel thermo-responsive hydrophilic microspheres were prepared by free radical polymerization of methacrylate bovine serum albumin and N-isopropylacrylamide, as cross-linker and functional monomer, respectively. The incorporation of monomers in the network was confirmed by infrared spectroscopy, whi...
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| Veröffentlicht in: | Colloid and polymer science 2009-07, Vol.287 (7), p.779-787 |
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| container_title | Colloid and polymer science |
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| creator | Iemma, F Spizzirri, U. G Puoci, F Cirillo, G Curcio, M Parisi, O. I Picci, N |
| description | Novel thermo-responsive hydrophilic microspheres were prepared by free radical polymerization of methacrylate bovine serum albumin and N-isopropylacrylamide, as cross-linker and functional monomer, respectively. The incorporation of monomers in the network was confirmed by infrared spectroscopy, while the network density and shape of hydrogels strictly depend on concentration of monomers in the polymerization feed. The thermal analyses showed negative thermo-responsive behavior with pronounced water affinity of microspheres at temperature lower than lower critical solution temperature (LCST). The in vitro release studies of drug-loaded thermo-sensitive hydrogels were performed. Experimental data showed, for the copolymers with functional monomer/cross-linker ratio 1 showed prominent drug release in the swollen state. Below the hydrogel LCST, drug release through the swollen polymeric networks was observed, while a squeezing-out effect at temperature above the LCST was predominant. |
| doi_str_mv | 10.1007/s00396-009-2027-y |
| format | Article |
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G ; Puoci, F ; Cirillo, G ; Curcio, M ; Parisi, O. I ; Picci, N</creator><creatorcontrib>Iemma, F ; Spizzirri, U. G ; Puoci, F ; Cirillo, G ; Curcio, M ; Parisi, O. I ; Picci, N</creatorcontrib><description>Novel thermo-responsive hydrophilic microspheres were prepared by free radical polymerization of methacrylate bovine serum albumin and N-isopropylacrylamide, as cross-linker and functional monomer, respectively. The incorporation of monomers in the network was confirmed by infrared spectroscopy, while the network density and shape of hydrogels strictly depend on concentration of monomers in the polymerization feed. The thermal analyses showed negative thermo-responsive behavior with pronounced water affinity of microspheres at temperature lower than lower critical solution temperature (LCST). The in vitro release studies of drug-loaded thermo-sensitive hydrogels were performed. Experimental data showed, for the copolymers with functional monomer/cross-linker ratio <= 1, a predominant drug release in the collapsed state, while the copolymers with functional monomer/cross-linker ratio > 1 showed prominent drug release in the swollen state. Below the hydrogel LCST, drug release through the swollen polymeric networks was observed, while a squeezing-out effect at temperature above the LCST was predominant.</description><identifier>ISSN: 0303-402X</identifier><identifier>EISSN: 1435-1536</identifier><identifier>DOI: 10.1007/s00396-009-2027-y</identifier><identifier>CODEN: CPMSB6</identifier><language>eng</language><publisher>Berlin/Heidelberg: Berlin/Heidelberg : Springer-Verlag</publisher><subject>Applied sciences ; Biological and medical sciences ; Characterization and Evaluation of Materials ; Chemistry ; Chemistry and Materials Science ; Complex Fluids and Microfluidics ; Copolymers ; Crosslinking ; Density ; Drugs ; Exact sciences and technology ; Food Science ; General pharmacology ; Hydrogels ; Medical sciences ; Microspheres ; Monomers ; Nanotechnology and Microengineering ; Natural polymers ; Networks ; Original Contribution ; Pharmaceutical technology. Pharmaceutical industry ; Pharmacology. 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The thermal analyses showed negative thermo-responsive behavior with pronounced water affinity of microspheres at temperature lower than lower critical solution temperature (LCST). The in vitro release studies of drug-loaded thermo-sensitive hydrogels were performed. Experimental data showed, for the copolymers with functional monomer/cross-linker ratio <= 1, a predominant drug release in the collapsed state, while the copolymers with functional monomer/cross-linker ratio > 1 showed prominent drug release in the swollen state. 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| subjects | Applied sciences Biological and medical sciences Characterization and Evaluation of Materials Chemistry Chemistry and Materials Science Complex Fluids and Microfluidics Copolymers Crosslinking Density Drugs Exact sciences and technology Food Science General pharmacology Hydrogels Medical sciences Microspheres Monomers Nanotechnology and Microengineering Natural polymers Networks Original Contribution Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Physical Chemistry Physicochemistry of polymers Polymer Sciences Proteins Soft and Granular Matter |
| title | Synthesis and release profile analysis of thermo-sensitive albumin hydrogels |
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