Study of an infant brain subjected to periodic motion via a custom experimental apparatus design and finite element modelling
Abstract This paper presents a rig that was specifically designed to simulate the shaking of mechanical models of biological systems, especially those related to shaken baby syndrome (SBS). The scope of this paper includes the testing of an anthropomorphic model that simulates an infant head and pro...
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| Veröffentlicht in: | Journal of biomechanics 2010-11, Vol.43 (15), p.2887-2896 |
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| creator | Cheng, J Howard, I.C Rennison, M |
| description | Abstract This paper presents a rig that was specifically designed to simulate the shaking of mechanical models of biological systems, especially those related to shaken baby syndrome (SBS). The scope of this paper includes the testing of an anthropomorphic model that simulates an infant head and provides validation data for complex finite element (FE) modelling using three numerical methods (Lagrangian, Arbitrary-Lagrangian–Eulerian (ALE) and Eulerian method) for fluid structure coupling. The experiments for this study aim to provide an understanding of the influence of two factors on intracranial brain movement of the infant head during violent shaking: (1) the specific paediatric head structure: the anterior fontanelle and (2) the brain–skull interface. The results show that the Eulerian analysis method has significant advantages for the FSI modelling of brain–CSF–skull interactions over the more commonly used methods, e.g. the Lagrangian method. To the knowledge of the authors, this methodology has not been discussed in previous publication. The results indicate that the biomechanical investigation of SBS can provide more accurate results only if the skull with paediatric features and the brain–skull interface are correctly represented, which were overlooked in previous SBS studies. |
| doi_str_mv | 10.1016/j.jbiomech.2010.07.023 |
| format | Article |
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The scope of this paper includes the testing of an anthropomorphic model that simulates an infant head and provides validation data for complex finite element (FE) modelling using three numerical methods (Lagrangian, Arbitrary-Lagrangian–Eulerian (ALE) and Eulerian method) for fluid structure coupling. The experiments for this study aim to provide an understanding of the influence of two factors on intracranial brain movement of the infant head during violent shaking: (1) the specific paediatric head structure: the anterior fontanelle and (2) the brain–skull interface. The results show that the Eulerian analysis method has significant advantages for the FSI modelling of brain–CSF–skull interactions over the more commonly used methods, e.g. the Lagrangian method. To the knowledge of the authors, this methodology has not been discussed in previous publication. The results indicate that the biomechanical investigation of SBS can provide more accurate results only if the skull with paediatric features and the brain–skull interface are correctly represented, which were overlooked in previous SBS studies.</description><identifier>ISSN: 0021-9290</identifier><identifier>EISSN: 1873-2380</identifier><identifier>DOI: 10.1016/j.jbiomech.2010.07.023</identifier><identifier>PMID: 20708735</identifier><language>eng</language><publisher>Kidlington: Elsevier Ltd</publisher><subject>Adult and adolescent clinical studies ; Algorithms ; Anterior fontanelle ; Arbitrary-Lagrangian–Eulerian (ALE) ; Biological and medical sciences ; Biomechanical Phenomena ; Biomechanics ; Biomedical Engineering - instrumentation ; Brain ; Brain - physiopathology ; Brain–skull interface ; Computer simulation ; Computerized, statistical medical data processing and models in biomedicine ; Experimental apparatus ; Experiments ; Finite element ; Finite Element Analysis ; Finite element method ; Fluid structural interaction (FSI) ; Gelatin ; Head injuries ; Head injury ; Humans ; Infant ; Infants ; Injuries of the nervous system and the skull. Diseases due to physical agents ; Mathematical models ; Medical research ; Medical sciences ; Modelling ; Models and simulation ; Models, Neurological ; Movement - physiology ; Organic mental disorders. Neuropsychology ; Paediatrics ; Personal relationships ; Physical Medicine and Rehabilitation ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Shaken baby syndrome ; Shaken Baby Syndrome - etiology ; Shaken Baby Syndrome - physiopathology ; Stress, Mechanical ; Studies ; Traumas. Diseases due to physical agents</subject><ispartof>Journal of biomechanics, 2010-11, Vol.43 (15), p.2887-2896</ispartof><rights>Elsevier Ltd</rights><rights>2010 Elsevier Ltd</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2010 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c481t-bdf4222ba7f587aa88bbe09d24d314fc3113a42951aa24bb265df3fad79ca5d83</citedby><cites>FETCH-LOGICAL-c481t-bdf4222ba7f587aa88bbe09d24d314fc3113a42951aa24bb265df3fad79ca5d83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1034965560?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,45974,64362,64364,64366,72216</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23429010$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20708735$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cheng, J</creatorcontrib><creatorcontrib>Howard, I.C</creatorcontrib><creatorcontrib>Rennison, M</creatorcontrib><title>Study of an infant brain subjected to periodic motion via a custom experimental apparatus design and finite element modelling</title><title>Journal of biomechanics</title><addtitle>J Biomech</addtitle><description>Abstract This paper presents a rig that was specifically designed to simulate the shaking of mechanical models of biological systems, especially those related to shaken baby syndrome (SBS). The scope of this paper includes the testing of an anthropomorphic model that simulates an infant head and provides validation data for complex finite element (FE) modelling using three numerical methods (Lagrangian, Arbitrary-Lagrangian–Eulerian (ALE) and Eulerian method) for fluid structure coupling. The experiments for this study aim to provide an understanding of the influence of two factors on intracranial brain movement of the infant head during violent shaking: (1) the specific paediatric head structure: the anterior fontanelle and (2) the brain–skull interface. The results show that the Eulerian analysis method has significant advantages for the FSI modelling of brain–CSF–skull interactions over the more commonly used methods, e.g. the Lagrangian method. To the knowledge of the authors, this methodology has not been discussed in previous publication. The results indicate that the biomechanical investigation of SBS can provide more accurate results only if the skull with paediatric features and the brain–skull interface are correctly represented, which were overlooked in previous SBS studies.</description><subject>Adult and adolescent clinical studies</subject><subject>Algorithms</subject><subject>Anterior fontanelle</subject><subject>Arbitrary-Lagrangian–Eulerian (ALE)</subject><subject>Biological and medical sciences</subject><subject>Biomechanical Phenomena</subject><subject>Biomechanics</subject><subject>Biomedical Engineering - instrumentation</subject><subject>Brain</subject><subject>Brain - physiopathology</subject><subject>Brain–skull interface</subject><subject>Computer simulation</subject><subject>Computerized, statistical medical data processing and models in biomedicine</subject><subject>Experimental apparatus</subject><subject>Experiments</subject><subject>Finite element</subject><subject>Finite Element Analysis</subject><subject>Finite element method</subject><subject>Fluid structural interaction (FSI)</subject><subject>Gelatin</subject><subject>Head injuries</subject><subject>Head injury</subject><subject>Humans</subject><subject>Infant</subject><subject>Infants</subject><subject>Injuries of the nervous system and the skull. Diseases due to physical agents</subject><subject>Mathematical models</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>Modelling</subject><subject>Models and simulation</subject><subject>Models, Neurological</subject><subject>Movement - physiology</subject><subject>Organic mental disorders. Neuropsychology</subject><subject>Paediatrics</subject><subject>Personal relationships</subject><subject>Physical Medicine and Rehabilitation</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Shaken baby syndrome</subject><subject>Shaken Baby Syndrome - etiology</subject><subject>Shaken Baby Syndrome - physiopathology</subject><subject>Stress, Mechanical</subject><subject>Studies</subject><subject>Traumas. 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Diseases due to physical agents</topic><topic>Mathematical models</topic><topic>Medical research</topic><topic>Medical sciences</topic><topic>Modelling</topic><topic>Models and simulation</topic><topic>Models, Neurological</topic><topic>Movement - physiology</topic><topic>Organic mental disorders. Neuropsychology</topic><topic>Paediatrics</topic><topic>Personal relationships</topic><topic>Physical Medicine and Rehabilitation</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Shaken baby syndrome</topic><topic>Shaken Baby Syndrome - etiology</topic><topic>Shaken Baby Syndrome - physiopathology</topic><topic>Stress, Mechanical</topic><topic>Studies</topic><topic>Traumas. Diseases due to physical agents</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cheng, J</creatorcontrib><creatorcontrib>Howard, I.C</creatorcontrib><creatorcontrib>Rennison, M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Physical Education Index</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><jtitle>Journal of biomechanics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cheng, J</au><au>Howard, I.C</au><au>Rennison, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Study of an infant brain subjected to periodic motion via a custom experimental apparatus design and finite element modelling</atitle><jtitle>Journal of biomechanics</jtitle><addtitle>J Biomech</addtitle><date>2010-11-16</date><risdate>2010</risdate><volume>43</volume><issue>15</issue><spage>2887</spage><epage>2896</epage><pages>2887-2896</pages><issn>0021-9290</issn><eissn>1873-2380</eissn><abstract>Abstract This paper presents a rig that was specifically designed to simulate the shaking of mechanical models of biological systems, especially those related to shaken baby syndrome (SBS). The scope of this paper includes the testing of an anthropomorphic model that simulates an infant head and provides validation data for complex finite element (FE) modelling using three numerical methods (Lagrangian, Arbitrary-Lagrangian–Eulerian (ALE) and Eulerian method) for fluid structure coupling. The experiments for this study aim to provide an understanding of the influence of two factors on intracranial brain movement of the infant head during violent shaking: (1) the specific paediatric head structure: the anterior fontanelle and (2) the brain–skull interface. The results show that the Eulerian analysis method has significant advantages for the FSI modelling of brain–CSF–skull interactions over the more commonly used methods, e.g. the Lagrangian method. To the knowledge of the authors, this methodology has not been discussed in previous publication. The results indicate that the biomechanical investigation of SBS can provide more accurate results only if the skull with paediatric features and the brain–skull interface are correctly represented, which were overlooked in previous SBS studies.</abstract><cop>Kidlington</cop><pub>Elsevier Ltd</pub><pmid>20708735</pmid><doi>10.1016/j.jbiomech.2010.07.023</doi><tpages>10</tpages></addata></record> |
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| ispartof | Journal of biomechanics, 2010-11, Vol.43 (15), p.2887-2896 |
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| subjects | Adult and adolescent clinical studies Algorithms Anterior fontanelle Arbitrary-Lagrangian–Eulerian (ALE) Biological and medical sciences Biomechanical Phenomena Biomechanics Biomedical Engineering - instrumentation Brain Brain - physiopathology Brain–skull interface Computer simulation Computerized, statistical medical data processing and models in biomedicine Experimental apparatus Experiments Finite element Finite Element Analysis Finite element method Fluid structural interaction (FSI) Gelatin Head injuries Head injury Humans Infant Infants Injuries of the nervous system and the skull. Diseases due to physical agents Mathematical models Medical research Medical sciences Modelling Models and simulation Models, Neurological Movement - physiology Organic mental disorders. Neuropsychology Paediatrics Personal relationships Physical Medicine and Rehabilitation Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Shaken baby syndrome Shaken Baby Syndrome - etiology Shaken Baby Syndrome - physiopathology Stress, Mechanical Studies Traumas. Diseases due to physical agents |
| title | Study of an infant brain subjected to periodic motion via a custom experimental apparatus design and finite element modelling |
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