Involvement of α- and β-catenins and E-cadherin in the development of mammary phyllodes tumours
Tsang J Y S, Mendoza P, Lam C C F, Yu A M C, Putti T C, Karim R Z, Scolyer R A, Lee C S, Tan P H & Tse G M (2012) Histopathology 61, 667–674 Involvement of α‐ and β‐catenins and E‐cadherin in the development of mammary phyllodes tumours Aims: Phyllodes tumours (PT) are rare but clinically impo...
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| Veröffentlicht in: | Histopathology 2012-10, Vol.61 (4), p.667-674 |
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| creator | Tsang, Julia Y S Mendoza, Paulo Lam, Christopher C F Yu, Alex M C Putti, Thomas C Karim, Rooshdiya Z Scolyer, Richard A Lee, Cheok Soon Tan, Puay Hoon Tse, Gary M |
| description | Tsang J Y S, Mendoza P, Lam C C F, Yu A M C, Putti T C, Karim R Z, Scolyer R A, Lee C S, Tan P H & Tse G M
(2012) Histopathology 61, 667–674
Involvement of α‐ and β‐catenins and E‐cadherin in the development of mammary phyllodes tumours
Aims: Phyllodes tumours (PT) are rare but clinically important fibroepithelial tumours of the breast. β‐Catenin, a key component in Wnt signalling, has been shown to be important in the development of PT. It also functions as a component of the cadherin complex, which may therefore be implicated in PT pathogenesis. By assessing stromal α‐catenin, β‐catenin and E‐cadherin expression in 158 PT cases using immunohistochemistry and examining associations with clinicopathological features, we aimed to determine the role of these proteins in PT pathogenesis.
Methods and results: Cytoplasmic β‐catenin correlated with α‐catenin expression. A significantly higher expression of both markers was observed in borderline than in benign PT (P = 0.003 and |
| doi_str_mv | 10.1111/j.1365-2559.2012.04271.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1671222717</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1671222717</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4371-302f1137829fc97237b7586d1ebb2cc1ff2be8aec5bac39d5e0f12001e44819a3</originalsourceid><addsrcrecordid>eNqNkN9u2yAUh1G1qs26vcLEzaTd2OOPMfbFLraoayNV7cVa9RJhfFCcYTsDO00ea3uQPtNwk2a3Q0hwxPeDw4cQpiSlcXxepZTnImFClCkjlKUkY5Km2xM0Ox68QTPCSZkQmstz9DaEFSFUcsbO0DljQtJMsBnSi27Tuw200A24t_j5d4J1V-PnP4nRA3RNF17qy1jWS_BNh-McloBr2IDr16_BVret9ju8Xu6c62sIeBjbfvThHTq12gV4f1gv0MP3y_v5dXJzd7WYf71JTMYlTThhllIuC1ZaU0rGZSVFkdcUqooZQ61lFRQajKi04WUtgFjK4pcgywpaan6BPu3vXfv-1whhUG0TDDinO-jHoKIGyljUJCNa7FHj-xA8WLX2zdS9okRNgtVKTR7V5FFNgtWLYLWN0Q-HV8aqhfoYfDUagY8HQAejnfW6M034x-VCEkIm7suee2oc7P67AXW9-DHtYj7Z55swwPaY1_6nyiWXQj3eXqk5Jd-YfJyrW_4XaaOmjA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1671222717</pqid></control><display><type>article</type><title>Involvement of α- and β-catenins and E-cadherin in the development of mammary phyllodes tumours</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Tsang, Julia Y S ; Mendoza, Paulo ; Lam, Christopher C F ; Yu, Alex M C ; Putti, Thomas C ; Karim, Rooshdiya Z ; Scolyer, Richard A ; Lee, Cheok Soon ; Tan, Puay Hoon ; Tse, Gary M</creator><creatorcontrib>Tsang, Julia Y S ; Mendoza, Paulo ; Lam, Christopher C F ; Yu, Alex M C ; Putti, Thomas C ; Karim, Rooshdiya Z ; Scolyer, Richard A ; Lee, Cheok Soon ; Tan, Puay Hoon ; Tse, Gary M</creatorcontrib><description>Tsang J Y S, Mendoza P, Lam C C F, Yu A M C, Putti T C, Karim R Z, Scolyer R A, Lee C S, Tan P H & Tse G M
(2012) Histopathology 61, 667–674
Involvement of α‐ and β‐catenins and E‐cadherin in the development of mammary phyllodes tumours
Aims: Phyllodes tumours (PT) are rare but clinically important fibroepithelial tumours of the breast. β‐Catenin, a key component in Wnt signalling, has been shown to be important in the development of PT. It also functions as a component of the cadherin complex, which may therefore be implicated in PT pathogenesis. By assessing stromal α‐catenin, β‐catenin and E‐cadherin expression in 158 PT cases using immunohistochemistry and examining associations with clinicopathological features, we aimed to determine the role of these proteins in PT pathogenesis.
Methods and results: Cytoplasmic β‐catenin correlated with α‐catenin expression. A significantly higher expression of both markers was observed in borderline than in benign PT (P = 0.003 and <0.001, respectively), but a lower level was found in malignant PT. Cytoplasmic E‐cadherin expression was significantly higher in borderline and malignant than in benign PT (P = 0.001 and 0.012, respectively), but was not correlated with other markers. Both E‐cadherin and α‐catenin showed stronger correlations with histological parameters than β‐catenin. α‐Catenin showed a significant correlation with recurrence (P = 0.005 and 0.016, respectively).
Conclusions: α‐ and β‐catenins may be important in the early stages of PT development, while E‐cadherin may be required for malignant development. The correlation of α‐catenin expression with tumour recurrence may be relevant in predicting PT behaviour.</description><identifier>ISSN: 0309-0167</identifier><identifier>EISSN: 1365-2559</identifier><identifier>DOI: 10.1111/j.1365-2559.2012.04271.x</identifier><identifier>PMID: 22571452</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>alpha Catenin - biosynthesis ; beta Catenin - biosynthesis ; Biological and medical sciences ; Biomarkers, Tumor - metabolism ; Breast Neoplasms - metabolism ; Breast Neoplasms - pathology ; Cadherins - biosynthesis ; E-cadherin ; Female ; Humans ; Immunohistochemistry ; Investigative techniques, diagnostic techniques (general aspects) ; Medical sciences ; Neoplasm Recurrence, Local - metabolism ; Neoplasm Recurrence, Local - pathology ; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques ; Phyllodes Tumor - metabolism ; Phyllodes Tumor - pathology ; phyllodes tumour ; Prognosis ; α-catenin ; β-catenin</subject><ispartof>Histopathology, 2012-10, Vol.61 (4), p.667-674</ispartof><rights>2012 Blackwell Publishing Ltd</rights><rights>2015 INIST-CNRS</rights><rights>2012 Blackwell Publishing Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4371-302f1137829fc97237b7586d1ebb2cc1ff2be8aec5bac39d5e0f12001e44819a3</citedby><cites>FETCH-LOGICAL-c4371-302f1137829fc97237b7586d1ebb2cc1ff2be8aec5bac39d5e0f12001e44819a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2559.2012.04271.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2559.2012.04271.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26570002$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22571452$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tsang, Julia Y S</creatorcontrib><creatorcontrib>Mendoza, Paulo</creatorcontrib><creatorcontrib>Lam, Christopher C F</creatorcontrib><creatorcontrib>Yu, Alex M C</creatorcontrib><creatorcontrib>Putti, Thomas C</creatorcontrib><creatorcontrib>Karim, Rooshdiya Z</creatorcontrib><creatorcontrib>Scolyer, Richard A</creatorcontrib><creatorcontrib>Lee, Cheok Soon</creatorcontrib><creatorcontrib>Tan, Puay Hoon</creatorcontrib><creatorcontrib>Tse, Gary M</creatorcontrib><title>Involvement of α- and β-catenins and E-cadherin in the development of mammary phyllodes tumours</title><title>Histopathology</title><addtitle>Histopathology</addtitle><description>Tsang J Y S, Mendoza P, Lam C C F, Yu A M C, Putti T C, Karim R Z, Scolyer R A, Lee C S, Tan P H & Tse G M
(2012) Histopathology 61, 667–674
Involvement of α‐ and β‐catenins and E‐cadherin in the development of mammary phyllodes tumours
Aims: Phyllodes tumours (PT) are rare but clinically important fibroepithelial tumours of the breast. β‐Catenin, a key component in Wnt signalling, has been shown to be important in the development of PT. It also functions as a component of the cadherin complex, which may therefore be implicated in PT pathogenesis. By assessing stromal α‐catenin, β‐catenin and E‐cadherin expression in 158 PT cases using immunohistochemistry and examining associations with clinicopathological features, we aimed to determine the role of these proteins in PT pathogenesis.
Methods and results: Cytoplasmic β‐catenin correlated with α‐catenin expression. A significantly higher expression of both markers was observed in borderline than in benign PT (P = 0.003 and <0.001, respectively), but a lower level was found in malignant PT. Cytoplasmic E‐cadherin expression was significantly higher in borderline and malignant than in benign PT (P = 0.001 and 0.012, respectively), but was not correlated with other markers. Both E‐cadherin and α‐catenin showed stronger correlations with histological parameters than β‐catenin. α‐Catenin showed a significant correlation with recurrence (P = 0.005 and 0.016, respectively).
Conclusions: α‐ and β‐catenins may be important in the early stages of PT development, while E‐cadherin may be required for malignant development. The correlation of α‐catenin expression with tumour recurrence may be relevant in predicting PT behaviour.</description><subject>alpha Catenin - biosynthesis</subject><subject>beta Catenin - biosynthesis</subject><subject>Biological and medical sciences</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Breast Neoplasms - metabolism</subject><subject>Breast Neoplasms - pathology</subject><subject>Cadherins - biosynthesis</subject><subject>E-cadherin</subject><subject>Female</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Medical sciences</subject><subject>Neoplasm Recurrence, Local - metabolism</subject><subject>Neoplasm Recurrence, Local - pathology</subject><subject>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</subject><subject>Phyllodes Tumor - metabolism</subject><subject>Phyllodes Tumor - pathology</subject><subject>phyllodes tumour</subject><subject>Prognosis</subject><subject>α-catenin</subject><subject>β-catenin</subject><issn>0309-0167</issn><issn>1365-2559</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkN9u2yAUh1G1qs26vcLEzaTd2OOPMfbFLraoayNV7cVa9RJhfFCcYTsDO00ea3uQPtNwk2a3Q0hwxPeDw4cQpiSlcXxepZTnImFClCkjlKUkY5Km2xM0Ox68QTPCSZkQmstz9DaEFSFUcsbO0DljQtJMsBnSi27Tuw200A24t_j5d4J1V-PnP4nRA3RNF17qy1jWS_BNh-McloBr2IDr16_BVret9ju8Xu6c62sIeBjbfvThHTq12gV4f1gv0MP3y_v5dXJzd7WYf71JTMYlTThhllIuC1ZaU0rGZSVFkdcUqooZQ61lFRQajKi04WUtgFjK4pcgywpaan6BPu3vXfv-1whhUG0TDDinO-jHoKIGyljUJCNa7FHj-xA8WLX2zdS9okRNgtVKTR7V5FFNgtWLYLWN0Q-HV8aqhfoYfDUagY8HQAejnfW6M034x-VCEkIm7suee2oc7P67AXW9-DHtYj7Z55swwPaY1_6nyiWXQj3eXqk5Jd-YfJyrW_4XaaOmjA</recordid><startdate>201210</startdate><enddate>201210</enddate><creator>Tsang, Julia Y S</creator><creator>Mendoza, Paulo</creator><creator>Lam, Christopher C F</creator><creator>Yu, Alex M C</creator><creator>Putti, Thomas C</creator><creator>Karim, Rooshdiya Z</creator><creator>Scolyer, Richard A</creator><creator>Lee, Cheok Soon</creator><creator>Tan, Puay Hoon</creator><creator>Tse, Gary M</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201210</creationdate><title>Involvement of α- and β-catenins and E-cadherin in the development of mammary phyllodes tumours</title><author>Tsang, Julia Y S ; Mendoza, Paulo ; Lam, Christopher C F ; Yu, Alex M C ; Putti, Thomas C ; Karim, Rooshdiya Z ; Scolyer, Richard A ; Lee, Cheok Soon ; Tan, Puay Hoon ; Tse, Gary M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4371-302f1137829fc97237b7586d1ebb2cc1ff2be8aec5bac39d5e0f12001e44819a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>alpha Catenin - biosynthesis</topic><topic>beta Catenin - biosynthesis</topic><topic>Biological and medical sciences</topic><topic>Biomarkers, Tumor - metabolism</topic><topic>Breast Neoplasms - metabolism</topic><topic>Breast Neoplasms - pathology</topic><topic>Cadherins - biosynthesis</topic><topic>E-cadherin</topic><topic>Female</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Medical sciences</topic><topic>Neoplasm Recurrence, Local - metabolism</topic><topic>Neoplasm Recurrence, Local - pathology</topic><topic>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</topic><topic>Phyllodes Tumor - metabolism</topic><topic>Phyllodes Tumor - pathology</topic><topic>phyllodes tumour</topic><topic>Prognosis</topic><topic>α-catenin</topic><topic>β-catenin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tsang, Julia Y S</creatorcontrib><creatorcontrib>Mendoza, Paulo</creatorcontrib><creatorcontrib>Lam, Christopher C F</creatorcontrib><creatorcontrib>Yu, Alex M C</creatorcontrib><creatorcontrib>Putti, Thomas C</creatorcontrib><creatorcontrib>Karim, Rooshdiya Z</creatorcontrib><creatorcontrib>Scolyer, Richard A</creatorcontrib><creatorcontrib>Lee, Cheok Soon</creatorcontrib><creatorcontrib>Tan, Puay Hoon</creatorcontrib><creatorcontrib>Tse, Gary M</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Histopathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tsang, Julia Y S</au><au>Mendoza, Paulo</au><au>Lam, Christopher C F</au><au>Yu, Alex M C</au><au>Putti, Thomas C</au><au>Karim, Rooshdiya Z</au><au>Scolyer, Richard A</au><au>Lee, Cheok Soon</au><au>Tan, Puay Hoon</au><au>Tse, Gary M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Involvement of α- and β-catenins and E-cadherin in the development of mammary phyllodes tumours</atitle><jtitle>Histopathology</jtitle><addtitle>Histopathology</addtitle><date>2012-10</date><risdate>2012</risdate><volume>61</volume><issue>4</issue><spage>667</spage><epage>674</epage><pages>667-674</pages><issn>0309-0167</issn><eissn>1365-2559</eissn><abstract>Tsang J Y S, Mendoza P, Lam C C F, Yu A M C, Putti T C, Karim R Z, Scolyer R A, Lee C S, Tan P H & Tse G M
(2012) Histopathology 61, 667–674
Involvement of α‐ and β‐catenins and E‐cadherin in the development of mammary phyllodes tumours
Aims: Phyllodes tumours (PT) are rare but clinically important fibroepithelial tumours of the breast. β‐Catenin, a key component in Wnt signalling, has been shown to be important in the development of PT. It also functions as a component of the cadherin complex, which may therefore be implicated in PT pathogenesis. By assessing stromal α‐catenin, β‐catenin and E‐cadherin expression in 158 PT cases using immunohistochemistry and examining associations with clinicopathological features, we aimed to determine the role of these proteins in PT pathogenesis.
Methods and results: Cytoplasmic β‐catenin correlated with α‐catenin expression. A significantly higher expression of both markers was observed in borderline than in benign PT (P = 0.003 and <0.001, respectively), but a lower level was found in malignant PT. Cytoplasmic E‐cadherin expression was significantly higher in borderline and malignant than in benign PT (P = 0.001 and 0.012, respectively), but was not correlated with other markers. Both E‐cadherin and α‐catenin showed stronger correlations with histological parameters than β‐catenin. α‐Catenin showed a significant correlation with recurrence (P = 0.005 and 0.016, respectively).
Conclusions: α‐ and β‐catenins may be important in the early stages of PT development, while E‐cadherin may be required for malignant development. The correlation of α‐catenin expression with tumour recurrence may be relevant in predicting PT behaviour.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>22571452</pmid><doi>10.1111/j.1365-2559.2012.04271.x</doi><tpages>8</tpages></addata></record> |
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| subjects | alpha Catenin - biosynthesis beta Catenin - biosynthesis Biological and medical sciences Biomarkers, Tumor - metabolism Breast Neoplasms - metabolism Breast Neoplasms - pathology Cadherins - biosynthesis E-cadherin Female Humans Immunohistochemistry Investigative techniques, diagnostic techniques (general aspects) Medical sciences Neoplasm Recurrence, Local - metabolism Neoplasm Recurrence, Local - pathology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Phyllodes Tumor - metabolism Phyllodes Tumor - pathology phyllodes tumour Prognosis α-catenin β-catenin |
| title | Involvement of α- and β-catenins and E-cadherin in the development of mammary phyllodes tumours |
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