Helicobacter pylori treatment in children: Defining a dose for rabeprazole as a part of a triple therapy regimen

The proton pump inhibitor, rabeprazole, has been studied in children for the treatment of gastroesophageal reflux disease (GERD). In adults, rabeprazole is indicated for Helicobacter pylori eradication in combination with amoxicillin and clarithromycin. Nonlinear mixed effects modeling was conducted...

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Veröffentlicht in:	Journal of clinical pharmacology 2015-05, Vol.55 (5), p.592-600
Hauptverfasser:	Kimko, Holly, Thyssen, An, Mould, Diane R., Mannaert, Erik, Treem, William R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Amoxicillin - administration & dosage Area Under Curve Body Weight Child Child, Preschool children Clarithromycin - administration & dosage Clinical Trials, Phase I as Topic Clinical Trials, Phase III as Topic Dose-Response Relationship, Drug Drug Therapy, Combination Female Gastroesophageal reflux Helicobacter Infections - drug therapy Helicobacter pylori Humans Infant Male proton pump inhibitor Proton Pump Inhibitors - administration & dosage Proton Pump Inhibitors - pharmacokinetics Proton Pump Inhibitors - therapeutic use rabeprazole Rabeprazole - administration & dosage Rabeprazole - pharmacokinetics Rabeprazole - therapeutic use triple therapy Ulcers
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