Pemphigoid with antibodies to laminin γ1, BP180 and BP230, associated with psoriasis vulgaris: Successful disease control with cyclosporin
Both anti‐laminin γ1 pemphigoid and bullous pemphigoid are autoimmune subepidermal blistering diseases. The former is rare and characterized by autoantibodies to laminin γ1, a 200‐kDa dermal protein, while the latter is common among the elderly and characterized by autoantibodies to BP180 and BP230,...
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| Veröffentlicht in: | Journal of dermatology 2015-04, Vol.42 (4), p.394-397 |
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| container_title | Journal of dermatology |
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| creator | Imanishi, Akiko Tateishi, Chiharu Imanishi, Hisayoshi Sowa-Osako, Junko Koga, Hiroshi Tsuruta, Daisuke Hashimoto, Takashi |
| description | Both anti‐laminin γ1 pemphigoid and bullous pemphigoid are autoimmune subepidermal blistering diseases. The former is rare and characterized by autoantibodies to laminin γ1, a 200‐kDa dermal protein, while the latter is common among the elderly and characterized by autoantibodies to BP180 and BP230, both of which are hemidesmosomal proteins. We experienced a 69‐year‐old Japanese male patient with blister formation secondary to erythrodermic psoriasis, which was successfully treated with cyclosporin. The histopathology of erythema corresponded with psoriasis and that of a blistering lesion showed infiltration of neutrophils and eosinophils in and around the subepidermal blisters. Patient immunoglobulin G antibodies labeled both the epidermal and dermal sides of 1 mol/L NaCl‐split human skin by indirect immunofluorescent microscopy and recognized laminin γ1, BP180 and BP230 by immunoblotting. To the best of our knowledge, this is the first report of coexistence of psoriasis and atypical pemphigoid with these three autoantibodies. |
| doi_str_mv | 10.1111/1346-8138.12798 |
| format | Article |
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The former is rare and characterized by autoantibodies to laminin γ1, a 200‐kDa dermal protein, while the latter is common among the elderly and characterized by autoantibodies to BP180 and BP230, both of which are hemidesmosomal proteins. We experienced a 69‐year‐old Japanese male patient with blister formation secondary to erythrodermic psoriasis, which was successfully treated with cyclosporin. The histopathology of erythema corresponded with psoriasis and that of a blistering lesion showed infiltration of neutrophils and eosinophils in and around the subepidermal blisters. Patient immunoglobulin G antibodies labeled both the epidermal and dermal sides of 1 mol/L NaCl‐split human skin by indirect immunofluorescent microscopy and recognized laminin γ1, BP180 and BP230 by immunoblotting. To the best of our knowledge, this is the first report of coexistence of psoriasis and atypical pemphigoid with these three autoantibodies.</description><identifier>ISSN: 0385-2407</identifier><identifier>EISSN: 1346-8138</identifier><identifier>DOI: 10.1111/1346-8138.12798</identifier><identifier>PMID: 25708520</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Aged ; Autoantibodies - metabolism ; Autoantigens - immunology ; BP180 ; Collagen Type XVII ; cyclosporin ; Cyclosporine - therapeutic use ; Dystonin - immunology ; Humans ; Immunosuppressive Agents - therapeutic use ; Laminin - immunology ; laminin γ1 ; Male ; Non-Fibrillar Collagens - immunology ; pemphigoid ; Pemphigoid, Bullous - drug therapy ; Pemphigoid, Bullous - immunology ; Pemphigoid, Bullous - pathology ; psoriasis ; Psoriasis - drug therapy ; Psoriasis - immunology ; Psoriasis - pathology</subject><ispartof>Journal of dermatology, 2015-04, Vol.42 (4), p.394-397</ispartof><rights>2015 Japanese Dermatological Association</rights><rights>2015 Japanese Dermatological Association.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2F1346-8138.12798$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2F1346-8138.12798$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25708520$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Imanishi, Akiko</creatorcontrib><creatorcontrib>Tateishi, Chiharu</creatorcontrib><creatorcontrib>Imanishi, Hisayoshi</creatorcontrib><creatorcontrib>Sowa-Osako, Junko</creatorcontrib><creatorcontrib>Koga, Hiroshi</creatorcontrib><creatorcontrib>Tsuruta, Daisuke</creatorcontrib><creatorcontrib>Hashimoto, Takashi</creatorcontrib><title>Pemphigoid with antibodies to laminin γ1, BP180 and BP230, associated with psoriasis vulgaris: Successful disease control with cyclosporin</title><title>Journal of dermatology</title><addtitle>J Dermatol</addtitle><description>Both anti‐laminin γ1 pemphigoid and bullous pemphigoid are autoimmune subepidermal blistering diseases. The former is rare and characterized by autoantibodies to laminin γ1, a 200‐kDa dermal protein, while the latter is common among the elderly and characterized by autoantibodies to BP180 and BP230, both of which are hemidesmosomal proteins. We experienced a 69‐year‐old Japanese male patient with blister formation secondary to erythrodermic psoriasis, which was successfully treated with cyclosporin. The histopathology of erythema corresponded with psoriasis and that of a blistering lesion showed infiltration of neutrophils and eosinophils in and around the subepidermal blisters. Patient immunoglobulin G antibodies labeled both the epidermal and dermal sides of 1 mol/L NaCl‐split human skin by indirect immunofluorescent microscopy and recognized laminin γ1, BP180 and BP230 by immunoblotting. To the best of our knowledge, this is the first report of coexistence of psoriasis and atypical pemphigoid with these three autoantibodies.</description><subject>Aged</subject><subject>Autoantibodies - metabolism</subject><subject>Autoantigens - immunology</subject><subject>BP180</subject><subject>Collagen Type XVII</subject><subject>cyclosporin</subject><subject>Cyclosporine - therapeutic use</subject><subject>Dystonin - immunology</subject><subject>Humans</subject><subject>Immunosuppressive Agents - therapeutic use</subject><subject>Laminin - immunology</subject><subject>laminin γ1</subject><subject>Male</subject><subject>Non-Fibrillar Collagens - immunology</subject><subject>pemphigoid</subject><subject>Pemphigoid, Bullous - drug therapy</subject><subject>Pemphigoid, Bullous - immunology</subject><subject>Pemphigoid, Bullous - pathology</subject><subject>psoriasis</subject><subject>Psoriasis - drug therapy</subject><subject>Psoriasis - immunology</subject><subject>Psoriasis - pathology</subject><issn>0385-2407</issn><issn>1346-8138</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kc1O3DAQx62qqCy0596Qjz0Q8Fdsh1vZ8lGE2q1o1aPlOA4YnDjNJMA-Qx-n79Fnapbdri8ezfx-c5g_Qu8pOaLTO6ZcyExTro8oU4V-hWbbzms0I1znGRNE7aI9gHtCWJFT8gbtslwRnTMyQ78Xvunuwm0KFX4Kwx227RDKVAUPeEg42ia0ocV__9BDfLqgmkxANVWMk0NsAZILdvAbt4PUBwsB8OMYb20f4ATfjM55gHqMuArgLXjsUjv0Ka4dt3QxQTeJ7Vu0U9sI_t3m30c_zs--zy-z668Xn-cfr7PAuNCZZTn1RFqpK1pTZaXzRe0qwZngSuVKu8IVUnBXKisKWmvvRFlpXtelmG5W8H30Yb2369Ov0cNgmgDOx2hbn0YwVCrKqNRET-jBBh3Lxlem60Nj-6X5f8AJyNfAU4h-uZ1TYlb5mFUaZpWGecnHXH06eykmL1t7AQb_vPVs_2Ck4io3P79cmPPFNynV_Mrc8H_C1JIj</recordid><startdate>201504</startdate><enddate>201504</enddate><creator>Imanishi, Akiko</creator><creator>Tateishi, Chiharu</creator><creator>Imanishi, Hisayoshi</creator><creator>Sowa-Osako, Junko</creator><creator>Koga, Hiroshi</creator><creator>Tsuruta, Daisuke</creator><creator>Hashimoto, Takashi</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>201504</creationdate><title>Pemphigoid with antibodies to laminin γ1, BP180 and BP230, associated with psoriasis vulgaris: Successful disease control with cyclosporin</title><author>Imanishi, Akiko ; Tateishi, Chiharu ; Imanishi, Hisayoshi ; Sowa-Osako, Junko ; Koga, Hiroshi ; Tsuruta, Daisuke ; Hashimoto, Takashi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i2348-a251e06a68d1f17a6ce9fcd4324377578c9c9643cb7a491f8ec4bd83ffb411193</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Aged</topic><topic>Autoantibodies - metabolism</topic><topic>Autoantigens - immunology</topic><topic>BP180</topic><topic>Collagen Type XVII</topic><topic>cyclosporin</topic><topic>Cyclosporine - therapeutic use</topic><topic>Dystonin - immunology</topic><topic>Humans</topic><topic>Immunosuppressive Agents - therapeutic use</topic><topic>Laminin - immunology</topic><topic>laminin γ1</topic><topic>Male</topic><topic>Non-Fibrillar Collagens - immunology</topic><topic>pemphigoid</topic><topic>Pemphigoid, Bullous - drug therapy</topic><topic>Pemphigoid, Bullous - immunology</topic><topic>Pemphigoid, Bullous - pathology</topic><topic>psoriasis</topic><topic>Psoriasis - drug therapy</topic><topic>Psoriasis - immunology</topic><topic>Psoriasis - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Imanishi, Akiko</creatorcontrib><creatorcontrib>Tateishi, Chiharu</creatorcontrib><creatorcontrib>Imanishi, Hisayoshi</creatorcontrib><creatorcontrib>Sowa-Osako, Junko</creatorcontrib><creatorcontrib>Koga, Hiroshi</creatorcontrib><creatorcontrib>Tsuruta, Daisuke</creatorcontrib><creatorcontrib>Hashimoto, Takashi</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Imanishi, Akiko</au><au>Tateishi, Chiharu</au><au>Imanishi, Hisayoshi</au><au>Sowa-Osako, Junko</au><au>Koga, Hiroshi</au><au>Tsuruta, Daisuke</au><au>Hashimoto, Takashi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pemphigoid with antibodies to laminin γ1, BP180 and BP230, associated with psoriasis vulgaris: Successful disease control with cyclosporin</atitle><jtitle>Journal of dermatology</jtitle><addtitle>J Dermatol</addtitle><date>2015-04</date><risdate>2015</risdate><volume>42</volume><issue>4</issue><spage>394</spage><epage>397</epage><pages>394-397</pages><issn>0385-2407</issn><eissn>1346-8138</eissn><abstract>Both anti‐laminin γ1 pemphigoid and bullous pemphigoid are autoimmune subepidermal blistering diseases. The former is rare and characterized by autoantibodies to laminin γ1, a 200‐kDa dermal protein, while the latter is common among the elderly and characterized by autoantibodies to BP180 and BP230, both of which are hemidesmosomal proteins. We experienced a 69‐year‐old Japanese male patient with blister formation secondary to erythrodermic psoriasis, which was successfully treated with cyclosporin. The histopathology of erythema corresponded with psoriasis and that of a blistering lesion showed infiltration of neutrophils and eosinophils in and around the subepidermal blisters. Patient immunoglobulin G antibodies labeled both the epidermal and dermal sides of 1 mol/L NaCl‐split human skin by indirect immunofluorescent microscopy and recognized laminin γ1, BP180 and BP230 by immunoblotting. To the best of our knowledge, this is the first report of coexistence of psoriasis and atypical pemphigoid with these three autoantibodies.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>25708520</pmid><doi>10.1111/1346-8138.12798</doi><tpages>4</tpages></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Aged Autoantibodies - metabolism Autoantigens - immunology BP180 Collagen Type XVII cyclosporin Cyclosporine - therapeutic use Dystonin - immunology Humans Immunosuppressive Agents - therapeutic use Laminin - immunology laminin γ1 Male Non-Fibrillar Collagens - immunology pemphigoid Pemphigoid, Bullous - drug therapy Pemphigoid, Bullous - immunology Pemphigoid, Bullous - pathology psoriasis Psoriasis - drug therapy Psoriasis - immunology Psoriasis - pathology |
| title | Pemphigoid with antibodies to laminin γ1, BP180 and BP230, associated with psoriasis vulgaris: Successful disease control with cyclosporin |
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