Creatine Inhibits Adipogenesis by Downregulating Insulin-Induced Activation of the Phosphatidylinositol 3-Kinase Signaling Pathway

Creatine is a nitrogenous organic acid known to function in adenosine triphosphate (ATP) metabolism. Recent evidence indicates that creatine regulates the differentiation of mesenchymal stem cells (MSCs) in processes such as osteogenesis and myogenesis. In this study, we show that creatine also has...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Stem cells and development 2015-04, Vol.24 (8), p.983-994
Hauptverfasser:	Lee, Nayeon, Kim, Inhee, Park, Soojeong, Han, Dasol, Ha, Soobong, Kwon, Mookwang, Kim, Juwan, Byun, Sung-Hyun, Oh, Wonil, Jeon, Hong Bae, Kweon, Dae-Hyuk, Cho, Jae Youl, Yoon, Keejung
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells Adipogenesis Animals CCAAT-Enhancer-Binding Protein-alpha - genetics CCAAT-Enhancer-Binding Protein-alpha - metabolism Cells, Cultured Complement Factor D - genetics Complement Factor D - metabolism Creatine - pharmacology Down-Regulation Fatty Acid-Binding Proteins - genetics Fatty Acid-Binding Proteins - metabolism Glucose Transporter Type 1 - genetics Glucose Transporter Type 1 - metabolism Glucose Transporter Type 4 - genetics Glucose Transporter Type 4 - metabolism Humans Insulin - pharmacology Male Mesenchymal Stromal Cells - cytology Mesenchymal Stromal Cells - drug effects Mesenchymal Stromal Cells - metabolism Mice Mice, Inbred C57BL Original Research Reports Phosphatidylinositol 3-Kinases - metabolism PPAR gamma - genetics PPAR gamma - metabolism Signal Transduction Triglycerides - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!