Molecular Mechanism of Poly(vinyl alcohol) Mediated Prevention of Aggregation and Stabilization of Insulin in Nanoparticles

It is a challenge to formulate polymer based nanoparticles of therapeutic proteins as excipients and process conditions affect stability and structural integrity of the protein. Hence, understanding the protein stability and complex aggregation phenomena is an important area of research in therapeut...

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Veröffentlicht in:	Molecular pharmaceutics 2015-04, Vol.12 (4), p.1018-1030
Hauptverfasser:	Rawat, Sanjay, Gupta, Pawan, Kumar, Anil, Garg, Prabha, Suri, C. Raman, Sahoo, Debendra K
Format:	Artikel
Sprache:	eng
Schlagworte:	Acrylamides - chemistry Animals Calorimetry, Differential Scanning Cattle Chlorides - chemistry Circular Dichroism Diabetes Mellitus, Experimental - drug therapy Female Guanidine - chemistry Insulin - chemistry Lactic Acid - chemistry Microscopy, Electron, Scanning Molecular Docking Simulation Molecular Weight Nanoparticles - chemistry Pancreas - metabolism Particle Size Polyglactin 910 - chemistry Polyglycolic Acid - chemistry Polymers - chemistry Polysorbates - chemistry Polyvinyl Alcohol - chemistry Protein Structure, Secondary Protein Structure, Tertiary Rats Rats, Sprague-Dawley Surface-Active Agents - chemistry Temperature
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