Mutation of serine-516 in human prostaglandin G/H synthase-2 to methionine or aspirin acetylation of this residue stimulates 15- R-HETE synthesis

Prostaglandin G/H synthase (PGHS) is a key enzyme in cellular prostaglandin (PG) synthesis and is the target of non-steroidal anti-inflammatory agents. PGHS occurs in two isoforms, termed PGHS-1 and PGHS-2. These isoforms differ in several respects, including their enzymatic activity following acety...

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Veröffentlicht in:FEBS letters 1994-03, Vol.342 (1), p.33-37
Hauptverfasser: Mancini, Joseph A., O'Neill, Gary P., Bayly, Christopher, Vickers, Philip J.
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Sprache:eng
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