Percutaneous absorption, dermatopharmacokinetics and related bio-transformation studies of carbaryl, lindane, malathion, and parathion in isolated perfused porcine skin

The percutaneous absorption of topically applied pesticides is a primary route for systemic exposure and potential toxicity. The isolated perfused porcine skin flap (IPPSF) is an in vitro model for studying percutaneous absorption of xenobiotics as well as cutaneous metabolism and toxicity in an ana...

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Veröffentlicht in:	Toxicology (Amsterdam) 1994-08, Vol.91 (3), p.269-280
Hauptverfasser:	Chang, S.K., Williams, P.L., Dauterman, W.C., Riviere, J.E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Biotransformation Carbaryl - pharmacokinetics Carbaryl - toxicity Culture Techniques Hexachlorocyclohexane - pharmacokinetics Hexachlorocyclohexane - toxicity Insecticides - pharmacokinetics Insecticides - toxicity Malathion - pharmacokinetics Malathion - toxicity Medical sciences Microcirculation - metabolism Parathion - pharmacokinetics Parathion - toxicity Percutaneous absorption Perfusion Pesticide Pesticides, fertilizers and other agrochemicals toxicology Skin - blood supply Skin - drug effects Skin - metabolism Skin Absorption Skin flap Swine Toxicology
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