Dopamine Neurotoxicity: Inhibition of Mitochondrial Respiration

: Dopamine, due to metabolism by monoamine oxidase or autoxidation, can generate toxic products such as hydrogen peroxide, oxygen‐derived radicals, semiquinones, and quinones and thus exert its neurotoxic effects. Intracerebroventricular injection of dopamine into rats pretreated with the monoamine...

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Veröffentlicht in:	Journal of neurochemistry 1995-02, Vol.64 (2), p.718-723
Hauptverfasser:	Ben‐Shachar, Dorit, Zuk, Roza, Glinka, Yelena
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Dopamine Dopamine - pharmacology Male Mitochondria - metabolism Mitochondrial NADH dehydrogenase NADH Dehydrogenase - metabolism Neurotoxicity Neurotoxins - pharmacology Norepinephrine Norepinephrine - pharmacology Oxidation-Reduction Oxidative stress state Oxygen - metabolism Rats Rats, Sprague-Dawley Stress, Physiological - metabolism Survival Analysis
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