Stereoselective microbial/enzymatic oxidation of (exo, exo)-7-oxabicyclo [2.2.1] heptane-2,3-dimethanol to the corresponding chiral lactol and lactone

A key chiral intermediate, lactol 2[3aS(3aα, 4α, 7α, 7aα)]-hexahydro-4,7-epoxy-isobenzofuran-1 (3H)-one, and the corresponding chiral lactone 3 were made in high optical purity by stereoselective enzymatic and microbial oxidation of the parent diol 1. Horse liver alcohol dehydrogenase (HLADH) in the...

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Veröffentlicht in:	Enzyme and microbial technology 1992, Vol.14 (10), p.778-784
Hauptverfasser:	Patel, Ramesh N., Liu, Mark, Banerjee, Amit, Thottathil, John K., Kloss, John, Szarka, Laszlo J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Bioconversions. Hemisynthesis Biological and medical sciences Biotechnology diol to lactol and lactone Fundamental and applied biological sciences. Psychology Methods. Procedures. Technologies microbial oxidation Rhodococcus stereoselective Thromboxane antagonist
Online-Zugang:	Volltext
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