Development of a human interleukin-6 receptor antagonist

Neutralizing monoclonal antibodies specific for human interleukin-6 (IL-6) bind two distinct sites on the IL-6 protein (sites I and II). Their interference with IL-6 receptor binding suggested that site I is a receptor-binding site of IL-6, whereas site II is important for signal transduction. Mutag...

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Veröffentlicht in:	The Journal of biological chemistry 1994-01, Vol.269 (1), p.86-93
Hauptverfasser:	BRAKENHOFF, J. P. J, DE HON, F. D, FONTAINE, V, TEN BOEKEL, E, SCHOOLTINK, H, ROSE-JOHN, S, HEINRICH, P. C, CONTENT, J, AARDEN, L. A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - pharmacology Biological and medical sciences Cell Line Cell receptors Cell structures and functions Fundamental and applied biological sciences. Psychology Hormone receptors. Growth factor receptors. Cytokine receptors. Prostaglandin receptors Humans Interleukin-6 - genetics Interleukin-6 - immunology Interleukin-6 - metabolism Mice Molecular and cellular biology Mutation Protein Binding Receptors, Interleukin - antagonists & inhibitors Receptors, Interleukin - metabolism Receptors, Interleukin-6 Signal Transduction
Online-Zugang:	Volltext
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