Efficient, specific cross-linking and cleavage of DNA by stable, synthetic complementary oligodeoxynucleotides
"Antisense" oligodeoxynucleotides (ODNs) have generated significant recent interest as potential chemotherapeutic agents. Despite theoretical appeal, the potency necessary for animal or clinical trials has not yet been shown. We have been investigating the attachment of a side chain, beari...
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| Veröffentlicht in: | Journal of the American Chemical Society 1989, Vol.111 (22), p.8517-8519 |
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| container_end_page | 8519 |
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| container_issue | 22 |
| container_start_page | 8517 |
| container_title | Journal of the American Chemical Society |
| container_volume | 111 |
| creator | MEYER, R. B TABONE, J. C HURST, G. D SMITH, T. M GAMPER, H |
| description | "Antisense" oligodeoxynucleotides (ODNs) have generated significant recent interest as potential chemotherapeutic agents. Despite theoretical appeal, the potency necessary for animal or clinical trials has not yet been shown. We have been investigating the attachment of a side chain, bearing an alkylating electrophile, to ODNs as a method of achieving irreversible inactivation of the complementary target nucleic acid. These ODNs can, as shown here, function as exceptionally selective cleavage reagents for DNA. |
| doi_str_mv | 10.1021/ja00204a034 |
| format | Article |
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These ODNs can, as shown here, function as exceptionally selective cleavage reagents for DNA.</description><identifier>ISSN: 0002-7863</identifier><identifier>EISSN: 1520-5126</identifier><identifier>DOI: 10.1021/ja00204a034</identifier><identifier>CODEN: JACSAT</identifier><language>eng</language><publisher>Washington, DC: American Chemical Society</publisher><subject>Analytical, structural and metabolic biochemistry ; Biological and medical sciences ; Dna, deoxyribonucleoproteins ; Fundamental and applied biological sciences. 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M</creatorcontrib><creatorcontrib>GAMPER, H</creatorcontrib><title>Efficient, specific cross-linking and cleavage of DNA by stable, synthetic complementary oligodeoxynucleotides</title><title>Journal of the American Chemical Society</title><description>"Antisense" oligodeoxynucleotides (ODNs) have generated significant recent interest as potential chemotherapeutic agents. Despite theoretical appeal, the potency necessary for animal or clinical trials has not yet been shown. We have been investigating the attachment of a side chain, bearing an alkylating electrophile, to ODNs as a method of achieving irreversible inactivation of the complementary target nucleic acid. These ODNs can, as shown here, function as exceptionally selective cleavage reagents for DNA.</description><subject>Analytical, structural and metabolic biochemistry</subject><subject>Biological and medical sciences</subject><subject>Dna, deoxyribonucleoproteins</subject><subject>Fundamental and applied biological sciences. 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B</creatorcontrib><creatorcontrib>TABONE, J. C</creatorcontrib><creatorcontrib>HURST, G. D</creatorcontrib><creatorcontrib>SMITH, T. M</creatorcontrib><creatorcontrib>GAMPER, H</creatorcontrib><collection>Pascal-Francis</collection><collection>Nucleic Acids Abstracts</collection><jtitle>Journal of the American Chemical Society</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MEYER, R. B</au><au>TABONE, J. C</au><au>HURST, G. D</au><au>SMITH, T. M</au><au>GAMPER, H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Efficient, specific cross-linking and cleavage of DNA by stable, synthetic complementary oligodeoxynucleotides</atitle><jtitle>Journal of the American Chemical Society</jtitle><date>1989</date><risdate>1989</risdate><volume>111</volume><issue>22</issue><spage>8517</spage><epage>8519</epage><pages>8517-8519</pages><issn>0002-7863</issn><eissn>1520-5126</eissn><coden>JACSAT</coden><abstract>"Antisense" oligodeoxynucleotides (ODNs) have generated significant recent interest as potential chemotherapeutic agents. Despite theoretical appeal, the potency necessary for animal or clinical trials has not yet been shown. We have been investigating the attachment of a side chain, bearing an alkylating electrophile, to ODNs as a method of achieving irreversible inactivation of the complementary target nucleic acid. These ODNs can, as shown here, function as exceptionally selective cleavage reagents for DNA.</abstract><cop>Washington, DC</cop><pub>American Chemical Society</pub><doi>10.1021/ja00204a034</doi><tpages>3</tpages></addata></record> |
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| ispartof | Journal of the American Chemical Society, 1989, Vol.111 (22), p.8517-8519 |
| issn | 0002-7863 1520-5126 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_16700255 |
| source | ACS Publications |
| subjects | Analytical, structural and metabolic biochemistry Biological and medical sciences Dna, deoxyribonucleoproteins Fundamental and applied biological sciences. Psychology Nucleic acids |
| title | Efficient, specific cross-linking and cleavage of DNA by stable, synthetic complementary oligodeoxynucleotides |
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