Glucocorticoids regulate the induction of phosphoenolpyruvate carboxykinase (GTP) gene transcription during diabetes

The hormonal regulation of transcription of the phosphoenolpyruvate carboxykinase (GTP) (4.1.1.32) (PEPCK) gene during diabetes was studied using transgenic mice containing a chimeric gene consisting of segments of the PEPCK promoter (-2000/+73, -460/ +73, -355/+73) linked to bovine growth hormone (...

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Veröffentlicht in:	The Journal of biological chemistry 1993-06, Vol.268 (17), p.12952-12957
Hauptverfasser:	Friedman, J.E, Yun, J.S, Patel, Y.M, McGrane, M.M, Hanson, R.W
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenalectomy Animals Biological and medical sciences carbohydrate loading Cattle Dexamethasone - pharmacology Diabetes Mellitus, Experimental - enzymology diet DNA Probes Enzyme Induction experimental diabetes Fundamental and applied biological sciences. Psychology gene expression Gene Expression Regulation, Enzymologic - drug effects Genes, fos genetic regulation glucocorticoids Growth Hormone - genetics high carbohydrate diet high protein diet Humans insulin Insulin - pharmacology Liver - enzymology Mice Mice, Transgenic Molecular and cellular biology Molecular genetics phosphoenolpyruvate carboxykinase Phosphoenolpyruvate Carboxykinase (GTP) - biosynthesis Phosphoenolpyruvate Carboxykinase (GTP) - genetics Prediabetic State - enzymology promoter regions Promoter Regions, Genetic protein intake recombinant DNA Recombinant Proteins - pharmacology Regulatory Sequences, Nucleic Acid reporter genes RNA - genetics RNA - isolation & purification RNA, Messenger - metabolism somatotropin transcription (genetics) Transcription, Genetic - drug effects Transcription. Transcription factor. Splicing. Rna processing transgenic animals
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