Extracellular matrix stiffness and composition jointly regulate the induction of malignant phenotypes in mammary epithelium

In vitro models of normal mammary epithelium have correlated increased extracellular matrix (ECM) stiffness with malignant phenotypes. However, the role of increased stiffness in this transformation remains unclear because of difficulties in controlling ECM stiffness, composition and architecture in...

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Veröffentlicht in:	Nature materials 2014-10, Vol.13 (10), p.970-978
Hauptverfasser:	Chaudhuri, Ovijit, Koshy, Sandeep T., Branco da Cunha, Cristiana, Shin, Jae-Won, Verbeke, Catia S., Allison, Kimberly H., Mooney, David J.
Format:	Artikel
Sprache:	eng
Schlagworte:	639/166/985 639/166/988 639/301/54/2295 639/301/923/1027 Alginates - metabolism Architecture Basement Membrane - physiology Basements Biocompatible Materials Biomaterials Biophysical Phenomena Cell Line Cell Transformation, Neoplastic - metabolism Cell Transformation, Neoplastic - pathology Cells Cellular biology Condensed Matter Physics Electrochemical machining Epithelium Epithelium - pathology Epithelium - physiopathology Extracellular Matrix - physiology Female Genotype & phenotype Glucuronic Acid - metabolism Hemidesmosomes - physiology Hexuronic Acids - metabolism Humans Integrin alpha6beta4 - metabolism Interpenetrating networks Ligands Mammary Glands, Human - pathology Mammary Glands, Human - physiopathology Materials Science Matrix Mechanotransduction, Cellular - physiology Membranes Models, Biological Nanotechnology Optical and Electronic Materials Phenotype Phosphatidylinositol 3-Kinases - metabolism rac1 GTP-Binding Protein - metabolism Signal Transduction Stiffness Transformations Tumors
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