Bothropic antivenom based on monoclonal antibodies, is it possible?

Neutralizing monoclonal antibodies against three major toxic components of Bothrops atrox venom were produced and tested. The mAbs against phospholipase A2, hemorrhagic metalloprotease, and thrombin-like enzymes were produced in large amounts and purified with caprylic acid followed by ammonium sulf...

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Veröffentlicht in:	Toxicon (Oxford) 2013-09, Vol.71, p.49-56
Hauptverfasser:	Frauches, Thiago S., Petretski, Jorge H., Arnholdt, Andrea C.V., Lasunskaia, Elena B., de Carvalho, Eulógio C.Q., Kipnis, Thereza L., da Silva, Wilmar D., Kanashiro, Milton M.
Format:	Artikel
Sprache:	eng
Schlagworte:	ammonium sulfate Ammonium Sulfate - metabolism Animals Antibodies, Monoclonal - immunology Antibodies, Monoclonal - pharmacology Antivenins - immunology Antivenins - pharmacology Antivenom antivenoms Blood Coagulation - drug effects Bothrops Bothrops atrox Caprylates - metabolism Crotalid Venoms - antagonists & inhibitors Crotalid Venoms - immunology Crotalid Venoms - toxicity Electrophoresis, Polyacrylamide Gel hemorrhage metalloproteinases Mice Monoclonal antibodies Neutralization Tests Neutralizing octanoic acid Phospholipase phospholipase A2 polyacrylamide gel electrophoresis Precipitation Snake venom Survival survival rate Toxicity Toxicology Toxins venoms
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