New 4-alkyl-1,4-dihydropyridines: Evaluation of photostability and phototoxic potential
The photostability and phototoxic potential of two new 4-alkyl-1,4-dihydropyridines (PCA-4230 and PCA-4248) were investigated. When these 4-alkyl-1,4-dihydropyridines were irradiated with a multilamp photoreactor (band centred at 350 nm), both exhibited a slow photodegradation showing first-order ki...
Gespeichert in:
| Veröffentlicht in: | Journal of photochemistry and photobiology. B, Biology Biology, 1993-07, Vol.19 (2), p.135-138 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 138 |
|---|---|
| container_issue | 2 |
| container_start_page | 135 |
| container_title | Journal of photochemistry and photobiology. B, Biology |
| container_volume | 19 |
| creator | Cortés, M.P. Cárdenas, A.M. Hidalgo, M.E. Glena, C. Fernández, E. Sunkel, C. |
| description | The photostability and phototoxic potential of two new 4-alkyl-1,4-dihydropyridines (PCA-4230 and PCA-4248) were investigated. When these 4-alkyl-1,4-dihydropyridines were irradiated with a multilamp photoreactor (band centred at 350 nm), both exhibited a slow photodegradation showing first-order kinetics. The photodegradation rate constants were 0.37 h
−1 for PCA-4248 and 0.39 h
−1 for PCA-4230 in oxygenated conditions. The photodecomposition was slower for both drugs in the absence of oxygen.
In order to evaluate the phototoxicity induced by these drugs, red blood cells and Hep-2 (human laringo carcinoma cell line) were irradiated using a minisolarium, which emits UVA radiation (350–390 nm). The results showed that PCA-4248 and PCA-4230 did not exhibit a phototoxic effect in the two models tested. |
| doi_str_mv | 10.1016/1011-1344(93)87108-Y |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_16698719</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>101113449387108Y</els_id><sourcerecordid>16698719</sourcerecordid><originalsourceid>FETCH-LOGICAL-c417t-b54c54d7fa17c5c1368aee0d768fe05018279a42357ff2e6807019e2127fbe133</originalsourceid><addsrcrecordid>eNp9kEFrFTEQgINYalv9Bwp7EKlgNLPJJlkPgpRqhaIXRXoKecmERvdttkle6_579_mePTaHyTDzzTB8hDwH9hYYyHdLAApciNOev9YKmKZXj8gRaMVpK3X7eMn_I0_IcSm_2PI6qQ7JoeZKMSWPyM-veNcIaoff80DhjaA-Xs8-p2nO0ccRy_vm_NYOG1tjGpsUmuk61VSqXcUh1rmxo9-VavoTXTOlimONdnhKDoIdCj7b_yfkx6fz72cX9PLb5y9nHy-pE6AqXXXCdcKrYEG5zgGX2iIyr6QOyDoGulW9FS3vVAgtSs0Ugx5baFVYIXB-Ql7t9k453WywVLOOxeEw2BHTphiQsl_c9AsodqDLqZSMwUw5rm2eDTCz9bkNYLayTM_NP5_mahl7sd-_Wa3R3w_tBS79l_u-Lc4OIdvRxXKPCa1Zz7fYhx2Gi4vbiNkUF3F06GNGV41P8eE7_gKHspEy</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>16698719</pqid></control><display><type>article</type><title>New 4-alkyl-1,4-dihydropyridines: Evaluation of photostability and phototoxic potential</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Cortés, M.P. ; Cárdenas, A.M. ; Hidalgo, M.E. ; Glena, C. ; Fernández, E. ; Sunkel, C.</creator><creatorcontrib>Cortés, M.P. ; Cárdenas, A.M. ; Hidalgo, M.E. ; Glena, C. ; Fernández, E. ; Sunkel, C.</creatorcontrib><description>The photostability and phototoxic potential of two new 4-alkyl-1,4-dihydropyridines (PCA-4230 and PCA-4248) were investigated. When these 4-alkyl-1,4-dihydropyridines were irradiated with a multilamp photoreactor (band centred at 350 nm), both exhibited a slow photodegradation showing first-order kinetics. The photodegradation rate constants were 0.37 h
−1 for PCA-4248 and 0.39 h
−1 for PCA-4230 in oxygenated conditions. The photodecomposition was slower for both drugs in the absence of oxygen.
In order to evaluate the phototoxicity induced by these drugs, red blood cells and Hep-2 (human laringo carcinoma cell line) were irradiated using a minisolarium, which emits UVA radiation (350–390 nm). The results showed that PCA-4248 and PCA-4230 did not exhibit a phototoxic effect in the two models tested.</description><identifier>ISSN: 1011-1344</identifier><identifier>EISSN: 1873-2682</identifier><identifier>DOI: 10.1016/1011-1344(93)87108-Y</identifier><identifier>PMID: 8377076</identifier><identifier>CODEN: JPPBEG</identifier><language>eng</language><publisher>Lausanne: Elsevier B.V</publisher><subject>4-Methyl-dihydropyridines ; Antithrombotic drug ; Biological and medical sciences ; Carcinoma, Squamous Cell ; Cell Survival - drug effects ; Cell Survival - radiation effects ; Dihydropyridines - chemistry ; Dihydropyridines - radiation effects ; Dihydropyridines - toxicity ; Drug toxicity and drugs side effects treatment ; Erythrocytes - drug effects ; Erythrocytes - radiation effects ; Fibrinolytic Agents - chemistry ; Humans ; Kinetics ; Light ; Medical sciences ; Miscellaneous (drug allergy, mutagens, teratogens...) ; Molecular Structure ; PAF antagonist ; Pharmacology. Drug treatments ; Photophysical properties ; Photosensitizing Agents - chemistry ; Photosensitizing Agents - toxicity ; Photostability ; Phototoxicity ; Time Factors ; Tumor Cells, Cultured ; UV light</subject><ispartof>Journal of photochemistry and photobiology. B, Biology, 1993-07, Vol.19 (2), p.135-138</ispartof><rights>1993</rights><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-b54c54d7fa17c5c1368aee0d768fe05018279a42357ff2e6807019e2127fbe133</citedby><cites>FETCH-LOGICAL-c417t-b54c54d7fa17c5c1368aee0d768fe05018279a42357ff2e6807019e2127fbe133</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/1011-1344(93)87108-Y$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4880936$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8377076$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cortés, M.P.</creatorcontrib><creatorcontrib>Cárdenas, A.M.</creatorcontrib><creatorcontrib>Hidalgo, M.E.</creatorcontrib><creatorcontrib>Glena, C.</creatorcontrib><creatorcontrib>Fernández, E.</creatorcontrib><creatorcontrib>Sunkel, C.</creatorcontrib><title>New 4-alkyl-1,4-dihydropyridines: Evaluation of photostability and phototoxic potential</title><title>Journal of photochemistry and photobiology. B, Biology</title><addtitle>J Photochem Photobiol B</addtitle><description>The photostability and phototoxic potential of two new 4-alkyl-1,4-dihydropyridines (PCA-4230 and PCA-4248) were investigated. When these 4-alkyl-1,4-dihydropyridines were irradiated with a multilamp photoreactor (band centred at 350 nm), both exhibited a slow photodegradation showing first-order kinetics. The photodegradation rate constants were 0.37 h
−1 for PCA-4248 and 0.39 h
−1 for PCA-4230 in oxygenated conditions. The photodecomposition was slower for both drugs in the absence of oxygen.
In order to evaluate the phototoxicity induced by these drugs, red blood cells and Hep-2 (human laringo carcinoma cell line) were irradiated using a minisolarium, which emits UVA radiation (350–390 nm). The results showed that PCA-4248 and PCA-4230 did not exhibit a phototoxic effect in the two models tested.</description><subject>4-Methyl-dihydropyridines</subject><subject>Antithrombotic drug</subject><subject>Biological and medical sciences</subject><subject>Carcinoma, Squamous Cell</subject><subject>Cell Survival - drug effects</subject><subject>Cell Survival - radiation effects</subject><subject>Dihydropyridines - chemistry</subject><subject>Dihydropyridines - radiation effects</subject><subject>Dihydropyridines - toxicity</subject><subject>Drug toxicity and drugs side effects treatment</subject><subject>Erythrocytes - drug effects</subject><subject>Erythrocytes - radiation effects</subject><subject>Fibrinolytic Agents - chemistry</subject><subject>Humans</subject><subject>Kinetics</subject><subject>Light</subject><subject>Medical sciences</subject><subject>Miscellaneous (drug allergy, mutagens, teratogens...)</subject><subject>Molecular Structure</subject><subject>PAF antagonist</subject><subject>Pharmacology. Drug treatments</subject><subject>Photophysical properties</subject><subject>Photosensitizing Agents - chemistry</subject><subject>Photosensitizing Agents - toxicity</subject><subject>Photostability</subject><subject>Phototoxicity</subject><subject>Time Factors</subject><subject>Tumor Cells, Cultured</subject><subject>UV light</subject><issn>1011-1344</issn><issn>1873-2682</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEFrFTEQgINYalv9Bwp7EKlgNLPJJlkPgpRqhaIXRXoKecmERvdttkle6_579_mePTaHyTDzzTB8hDwH9hYYyHdLAApciNOev9YKmKZXj8gRaMVpK3X7eMn_I0_IcSm_2PI6qQ7JoeZKMSWPyM-veNcIaoff80DhjaA-Xs8-p2nO0ccRy_vm_NYOG1tjGpsUmuk61VSqXcUh1rmxo9-VavoTXTOlimONdnhKDoIdCj7b_yfkx6fz72cX9PLb5y9nHy-pE6AqXXXCdcKrYEG5zgGX2iIyr6QOyDoGulW9FS3vVAgtSs0Ugx5baFVYIXB-Ql7t9k453WywVLOOxeEw2BHTphiQsl_c9AsodqDLqZSMwUw5rm2eDTCz9bkNYLayTM_NP5_mahl7sd-_Wa3R3w_tBS79l_u-Lc4OIdvRxXKPCa1Zz7fYhx2Gi4vbiNkUF3F06GNGV41P8eE7_gKHspEy</recordid><startdate>19930701</startdate><enddate>19930701</enddate><creator>Cortés, M.P.</creator><creator>Cárdenas, A.M.</creator><creator>Hidalgo, M.E.</creator><creator>Glena, C.</creator><creator>Fernández, E.</creator><creator>Sunkel, C.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>19930701</creationdate><title>New 4-alkyl-1,4-dihydropyridines: Evaluation of photostability and phototoxic potential</title><author>Cortés, M.P. ; Cárdenas, A.M. ; Hidalgo, M.E. ; Glena, C. ; Fernández, E. ; Sunkel, C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-b54c54d7fa17c5c1368aee0d768fe05018279a42357ff2e6807019e2127fbe133</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>4-Methyl-dihydropyridines</topic><topic>Antithrombotic drug</topic><topic>Biological and medical sciences</topic><topic>Carcinoma, Squamous Cell</topic><topic>Cell Survival - drug effects</topic><topic>Cell Survival - radiation effects</topic><topic>Dihydropyridines - chemistry</topic><topic>Dihydropyridines - radiation effects</topic><topic>Dihydropyridines - toxicity</topic><topic>Drug toxicity and drugs side effects treatment</topic><topic>Erythrocytes - drug effects</topic><topic>Erythrocytes - radiation effects</topic><topic>Fibrinolytic Agents - chemistry</topic><topic>Humans</topic><topic>Kinetics</topic><topic>Light</topic><topic>Medical sciences</topic><topic>Miscellaneous (drug allergy, mutagens, teratogens...)</topic><topic>Molecular Structure</topic><topic>PAF antagonist</topic><topic>Pharmacology. Drug treatments</topic><topic>Photophysical properties</topic><topic>Photosensitizing Agents - chemistry</topic><topic>Photosensitizing Agents - toxicity</topic><topic>Photostability</topic><topic>Phototoxicity</topic><topic>Time Factors</topic><topic>Tumor Cells, Cultured</topic><topic>UV light</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cortés, M.P.</creatorcontrib><creatorcontrib>Cárdenas, A.M.</creatorcontrib><creatorcontrib>Hidalgo, M.E.</creatorcontrib><creatorcontrib>Glena, C.</creatorcontrib><creatorcontrib>Fernández, E.</creatorcontrib><creatorcontrib>Sunkel, C.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Journal of photochemistry and photobiology. B, Biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cortés, M.P.</au><au>Cárdenas, A.M.</au><au>Hidalgo, M.E.</au><au>Glena, C.</au><au>Fernández, E.</au><au>Sunkel, C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>New 4-alkyl-1,4-dihydropyridines: Evaluation of photostability and phototoxic potential</atitle><jtitle>Journal of photochemistry and photobiology. B, Biology</jtitle><addtitle>J Photochem Photobiol B</addtitle><date>1993-07-01</date><risdate>1993</risdate><volume>19</volume><issue>2</issue><spage>135</spage><epage>138</epage><pages>135-138</pages><issn>1011-1344</issn><eissn>1873-2682</eissn><coden>JPPBEG</coden><abstract>The photostability and phototoxic potential of two new 4-alkyl-1,4-dihydropyridines (PCA-4230 and PCA-4248) were investigated. When these 4-alkyl-1,4-dihydropyridines were irradiated with a multilamp photoreactor (band centred at 350 nm), both exhibited a slow photodegradation showing first-order kinetics. The photodegradation rate constants were 0.37 h
−1 for PCA-4248 and 0.39 h
−1 for PCA-4230 in oxygenated conditions. The photodecomposition was slower for both drugs in the absence of oxygen.
In order to evaluate the phototoxicity induced by these drugs, red blood cells and Hep-2 (human laringo carcinoma cell line) were irradiated using a minisolarium, which emits UVA radiation (350–390 nm). The results showed that PCA-4248 and PCA-4230 did not exhibit a phototoxic effect in the two models tested.</abstract><cop>Lausanne</cop><cop>Amsterdam</cop><cop>New York, NY</cop><pub>Elsevier B.V</pub><pmid>8377076</pmid><doi>10.1016/1011-1344(93)87108-Y</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1011-1344 |
| ispartof | Journal of photochemistry and photobiology. B, Biology, 1993-07, Vol.19 (2), p.135-138 |
| issn | 1011-1344 1873-2682 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_16698719 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | 4-Methyl-dihydropyridines Antithrombotic drug Biological and medical sciences Carcinoma, Squamous Cell Cell Survival - drug effects Cell Survival - radiation effects Dihydropyridines - chemistry Dihydropyridines - radiation effects Dihydropyridines - toxicity Drug toxicity and drugs side effects treatment Erythrocytes - drug effects Erythrocytes - radiation effects Fibrinolytic Agents - chemistry Humans Kinetics Light Medical sciences Miscellaneous (drug allergy, mutagens, teratogens...) Molecular Structure PAF antagonist Pharmacology. Drug treatments Photophysical properties Photosensitizing Agents - chemistry Photosensitizing Agents - toxicity Photostability Phototoxicity Time Factors Tumor Cells, Cultured UV light |
| title | New 4-alkyl-1,4-dihydropyridines: Evaluation of photostability and phototoxic potential |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-22T04%3A00%3A19IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=New%204-alkyl-1,4-dihydropyridines:%20Evaluation%20of%20photostability%20and%20phototoxic%20potential&rft.jtitle=Journal%20of%20photochemistry%20and%20photobiology.%20B,%20Biology&rft.au=Cort%C3%A9s,%20M.P.&rft.date=1993-07-01&rft.volume=19&rft.issue=2&rft.spage=135&rft.epage=138&rft.pages=135-138&rft.issn=1011-1344&rft.eissn=1873-2682&rft.coden=JPPBEG&rft_id=info:doi/10.1016/1011-1344(93)87108-Y&rft_dat=%3Cproquest_cross%3E16698719%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=16698719&rft_id=info:pmid/8377076&rft_els_id=101113449387108Y&rfr_iscdi=true |