A clerodane diterpene inhibit adipogenesis by cell cycle arrest and ameliorate obesity in C57BL/6 mice

•For the first time, we report a Clerodane diterpene class of compound as an anti-adipogenic molecule.•Compound-1 exhibit beneficial effects as an anti-obesitic agent in high fat fed high BMI mice studies.•Anti-dyslipidemic and anti-obesitic properties of compound-1 proves it a potent translational...

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Veröffentlicht in:	Molecular and cellular endocrinology 2015-01, Vol.399, p.373-385
Hauptverfasser:	Beg, Muheeb, Shankar, Kripa, Varshney, Salil, Rajan, Sujith, Singh, Suriya Pratap, Jagdale, Pankaj, Puri, Anju, Chaudhari, Bhushan P., Sashidhara, Koneni V., Gaikwad, Anil Nilkanth
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3-L1 adipocyte Adipogenesis - drug effects Animals Biocompatibility CCAAT-Enhancer-Binding Proteins - metabolism Cell Cycle Checkpoints - drug effects Cell Line Cellular Clerodane diterpene Differentiation Diterpenes, Clerodane - chemistry Diterpenes, Clerodane - isolation & purification Diterpenes, Clerodane - pharmacology Glucose Glucose Transporter Type 4 - metabolism Humans Inhibitors Mesenchymal Stromal Cells - metabolism Mice Obesity Obesity - drug therapy Obesity - metabolism Obesity - pathology Orlistat PPAR gamma - metabolism Statins Tolerances Toxicity
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