Immunization with DISC1 protein in an animal model of ADHD influences behavior and excitatory amino acids in prefrontal cortex and striatum

The Disrupted - in - schizophrenia 1 (DISC1) gene is involved in vulnerability to neuropsychiatric disorders. Naples high-excitability (NHE) rat model neuropsychiatric problems characterized by an unbalanced mesocortical dopamine system. Here, we assessed behavioral and neurochemical effects of immu...

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Veröffentlicht in:	Amino acids 2015-03, Vol.47 (3), p.637-650
Hauptverfasser:	Ruocco, L. A., Treno, C., Gironi Carnevale, U. A., Arra, C., Boatto, G., Pagano, C., Tino, A., Nieddu, M., Michel, M., Prikulis, I., Carboni, E., de Souza Silva, M. A., Huston, J. P., Sadile, A. G., Korth, C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants Amino acids Analytical Chemistry Animals Aspartates Attention Deficit Disorder with Hyperactivity - chemically induced Attention Deficit Disorder with Hyperactivity - immunology Attention Deficit Disorder with Hyperactivity - metabolism Attention Deficit Disorder with Hyperactivity - physiopathology Behavior, Animal - drug effects Biochemical Engineering Biochemistry Biomedical and Life Sciences Brain Chemistry - drug effects Control equipment Escherichia coli Excitatory Amino Acids - immunology Excitatory Amino Acids - metabolism Glutamates Horizontal Immunization Life Sciences Male Maze Learning - drug effects Nerve Tissue Proteins - adverse effects Nerve Tissue Proteins - immunology Nerve Tissue Proteins - pharmacology Neurobiology Original Article Prefrontal Cortex - immunology Prefrontal Cortex - metabolism Prefrontal Cortex - physiopathology Proteomics Rats Rats, Sprague-Dawley
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