Temporal relationship between aquaporin-4 and glial fibrillary acidic protein in cerebellum of neonate and adult rats administered a BBB disrupting spider venom

Two astrocyte markers, the glial water channel aquaporin-4 (AQP4) and the glial fibrillary acidic protein (GFAP), have been implicated in several physiological and pathological conditions in the central nervous system (CNS) as well as in blood–brain barrier breakdown (BBBb). By color segmentation th...

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Veröffentlicht in:	Toxicon (Oxford) 2013-05, Vol.66, p.37-46
Hauptverfasser:	Stavale, Leila Miguel, Soares, Edilene Siqueira, Mendonça, Monique C.P., Irazusta, Silvia P., da Cruz Höfling, Maria Alice
Format:	Artikel
Sprache:	eng
Schlagworte:	Adults Age Factors Animals Animals, Newborn Aquaporin 4 - metabolism Araneae Astrocytes - drug effects Astrocytes - metabolism Astrocytes - pathology Biomarkers - metabolism Blood-Brain Barrier - drug effects Blood-Brain Barrier - metabolism Blood-Brain Barrier - pathology Blood–brain barrier Cell Membrane Permeability - drug effects Cell Membrane Permeability - physiology Central nervous system Cerebellum Cerebellum - drug effects Cerebellum - metabolism Channels color edema Edema - chemically induced Edema - metabolism Edema - pathology electrolytes GIMP Glial Fibrillary Acidic Protein - metabolism Image processing Image Processing, Computer-Assisted Male Markers neonates Perivascular edema permeability Phoneutria nigriventer potassium Proteins Rats Rats, Wistar Segmentation Spider Venoms - toxicity Spiders Time Factors venoms Water channel
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