Development of a more specific and accurate multiple reaction monitoring method based on GC–EI/MS/MS for simultaneously monitoring and determining 34 kinds of pesticides in Qianjinzhidai pills
•Thirty-four kinds of pesticides were monitored and determined by GC–EI/MS/MS.•A novel optimization method about ion transitions was provided.•This method can enhance the specificity of mass spectrum monitoring.•This method can improve the accuracy of content determination. A rapid and accurate mult...
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| Veröffentlicht in: | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Analytical technologies in the biomedical and life sciences, 2015-03, Vol.983-984, p.47-54 |
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| container_title | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences |
| container_volume | 983-984 |
| creator | Jiang, Yunbin Zhong, Mei Gou, Yan Peng, Wei Zhou, Juan Wu, Pie Ma, Yuying |
| description | •Thirty-four kinds of pesticides were monitored and determined by GC–EI/MS/MS.•A novel optimization method about ion transitions was provided.•This method can enhance the specificity of mass spectrum monitoring.•This method can improve the accuracy of content determination.
A rapid and accurate multi-residue method was developed for simultaneously monitoring and determining 34 kinds of pesticides by GC–EI/MS/MS, successfully applied in Qianjinzhidai pills. Precision, repeatability, stability, limit of detection (LOD), limit of quantification (LOQ), linearity range and accuracy tests were used to validate this method. The results, precision (RSD |
| doi_str_mv | 10.1016/j.jchromb.2015.01.002 |
| format | Article |
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A rapid and accurate multi-residue method was developed for simultaneously monitoring and determining 34 kinds of pesticides by GC–EI/MS/MS, successfully applied in Qianjinzhidai pills. Precision, repeatability, stability, limit of detection (LOD), limit of quantification (LOQ), linearity range and accuracy tests were used to validate this method. The results, precision (RSD<2%, n=6), repeatability (RSD<2%, n=6) and stability (RSD<2%, n=6), LOD (lower than 0.02mg/kg), LOQ (lower than 0.067mg/kg), linearity range (0.016–39.270μg/mL), recoveries (90–110%, RSD<15%, n=6), indicated that the method was feasible. This paper provided an optimization method about ion transitions which can improve the specificity of mass spectrum monitoring and the accuracy of content determination. This method can be also used to monitor and determine pesticide residues of other traditional Chinese medicine, but it was worth noting that the ion transitions should been again optimized according to the sample matrix.</description><identifier>ISSN: 1570-0232</identifier><identifier>EISSN: 1873-376X</identifier><identifier>DOI: 10.1016/j.jchromb.2015.01.002</identifier><identifier>PMID: 25618250</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Analytic Sample Preparation Methods ; Calibration ; Content determination ; Drugs, Chinese Herbal - chemistry ; Gas Chromatography-Mass Spectrometry - methods ; GC–EI/MS/MS ; Ion transitions ; Limit of Detection ; Linearity ; Monitoring ; Monitors ; Pesticide residues ; Pesticides ; Pesticides - analysis ; Pills ; Qianjinzhidai pills ; Reference Standards ; Repeatability ; Reproducibility ; Reproducibility of Results ; Spectrometry, Mass, Electrospray Ionization - methods ; Stability ; Traditional chinese medicine</subject><ispartof>Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2015-03, Vol.983-984, p.47-54</ispartof><rights>2015 Elsevier B.V.</rights><rights>Copyright © 2015 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c464t-72fa4b02d8fa6ca14de2a10713f984e65936bf8f599a14a28f06bafe6e09d8253</citedby><cites>FETCH-LOGICAL-c464t-72fa4b02d8fa6ca14de2a10713f984e65936bf8f599a14a28f06bafe6e09d8253</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jchromb.2015.01.002$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25618250$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jiang, Yunbin</creatorcontrib><creatorcontrib>Zhong, Mei</creatorcontrib><creatorcontrib>Gou, Yan</creatorcontrib><creatorcontrib>Peng, Wei</creatorcontrib><creatorcontrib>Zhou, Juan</creatorcontrib><creatorcontrib>Wu, Pie</creatorcontrib><creatorcontrib>Ma, Yuying</creatorcontrib><title>Development of a more specific and accurate multiple reaction monitoring method based on GC–EI/MS/MS for simultaneously monitoring and determining 34 kinds of pesticides in Qianjinzhidai pills</title><title>Journal of chromatography. B, Analytical technologies in the biomedical and life sciences</title><addtitle>J Chromatogr B Analyt Technol Biomed Life Sci</addtitle><description>•Thirty-four kinds of pesticides were monitored and determined by GC–EI/MS/MS.•A novel optimization method about ion transitions was provided.•This method can enhance the specificity of mass spectrum monitoring.•This method can improve the accuracy of content determination.
A rapid and accurate multi-residue method was developed for simultaneously monitoring and determining 34 kinds of pesticides by GC–EI/MS/MS, successfully applied in Qianjinzhidai pills. Precision, repeatability, stability, limit of detection (LOD), limit of quantification (LOQ), linearity range and accuracy tests were used to validate this method. The results, precision (RSD<2%, n=6), repeatability (RSD<2%, n=6) and stability (RSD<2%, n=6), LOD (lower than 0.02mg/kg), LOQ (lower than 0.067mg/kg), linearity range (0.016–39.270μg/mL), recoveries (90–110%, RSD<15%, n=6), indicated that the method was feasible. This paper provided an optimization method about ion transitions which can improve the specificity of mass spectrum monitoring and the accuracy of content determination. This method can be also used to monitor and determine pesticide residues of other traditional Chinese medicine, but it was worth noting that the ion transitions should been again optimized according to the sample matrix.</description><subject>Analytic Sample Preparation Methods</subject><subject>Calibration</subject><subject>Content determination</subject><subject>Drugs, Chinese Herbal - chemistry</subject><subject>Gas Chromatography-Mass Spectrometry - methods</subject><subject>GC–EI/MS/MS</subject><subject>Ion transitions</subject><subject>Limit of Detection</subject><subject>Linearity</subject><subject>Monitoring</subject><subject>Monitors</subject><subject>Pesticide residues</subject><subject>Pesticides</subject><subject>Pesticides - analysis</subject><subject>Pills</subject><subject>Qianjinzhidai pills</subject><subject>Reference Standards</subject><subject>Repeatability</subject><subject>Reproducibility</subject><subject>Reproducibility of Results</subject><subject>Spectrometry, Mass, Electrospray Ionization - methods</subject><subject>Stability</subject><subject>Traditional chinese medicine</subject><issn>1570-0232</issn><issn>1873-376X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkdGK1TAQhoso7rr6CEouvTlnk7RJ2yuR47ourIio4F1Ik4lnapvUpF1Yr3wH38hH8UlMOUfxTiGQDPPN_JP5i-Ixo1tGmTzvt73ZxzB2W06Z2FK2pZTfKU5ZU5ebspYf7-a3qOmG8pKfFA9S6illNa3L-8UJF5I1XNDT4scLuIEhTCP4mQRHNBlDBJImMOjQEO0t0cYsUc9AxmWYcRqARNBmxuAz7HEOEf0nMsK8D5Z0OoElOXW5-_nt-8XV-et3-RAXIkm4NtAewpKG279rVxULM8QR_RqXFfmM3qZ1ognSjAYtJIKevEXte_Rf92g1kgmHIT0s7jk9JHh0vM-KDy8v3u9eba7fXF7tnl9vTCWreVNzp6uOcts4LY1mlQWuGa1Z6dqmAinaUnaucaJtc1LzxlHZaQcSaGvzssqz4umh7xTDlyVPpUZMBobh8CPFpGwbUVai-Q9UlIwLUVcZFQfUxJBSBKemiKOOt4pRtTqtenV0Wq1OK8pUdjrXPTlKLN0I9k_Vb2sz8OwAQN7JDUJUySB4AxYjmFnZgP-Q-AXlJsFc</recordid><startdate>20150301</startdate><enddate>20150301</enddate><creator>Jiang, Yunbin</creator><creator>Zhong, Mei</creator><creator>Gou, Yan</creator><creator>Peng, Wei</creator><creator>Zhou, Juan</creator><creator>Wu, Pie</creator><creator>Ma, Yuying</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TB</scope><scope>8FD</scope><scope>FR3</scope></search><sort><creationdate>20150301</creationdate><title>Development of a more specific and accurate multiple reaction monitoring method based on GC–EI/MS/MS for simultaneously monitoring and determining 34 kinds of pesticides in Qianjinzhidai pills</title><author>Jiang, Yunbin ; Zhong, Mei ; Gou, Yan ; Peng, Wei ; Zhou, Juan ; Wu, Pie ; Ma, Yuying</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c464t-72fa4b02d8fa6ca14de2a10713f984e65936bf8f599a14a28f06bafe6e09d8253</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Analytic Sample Preparation Methods</topic><topic>Calibration</topic><topic>Content determination</topic><topic>Drugs, Chinese Herbal - chemistry</topic><topic>Gas Chromatography-Mass Spectrometry - methods</topic><topic>GC–EI/MS/MS</topic><topic>Ion transitions</topic><topic>Limit of Detection</topic><topic>Linearity</topic><topic>Monitoring</topic><topic>Monitors</topic><topic>Pesticide residues</topic><topic>Pesticides</topic><topic>Pesticides - analysis</topic><topic>Pills</topic><topic>Qianjinzhidai pills</topic><topic>Reference Standards</topic><topic>Repeatability</topic><topic>Reproducibility</topic><topic>Reproducibility of Results</topic><topic>Spectrometry, Mass, Electrospray Ionization - methods</topic><topic>Stability</topic><topic>Traditional chinese medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jiang, Yunbin</creatorcontrib><creatorcontrib>Zhong, Mei</creatorcontrib><creatorcontrib>Gou, Yan</creatorcontrib><creatorcontrib>Peng, Wei</creatorcontrib><creatorcontrib>Zhou, Juan</creatorcontrib><creatorcontrib>Wu, Pie</creatorcontrib><creatorcontrib>Ma, Yuying</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><jtitle>Journal of chromatography. B, Analytical technologies in the biomedical and life sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jiang, Yunbin</au><au>Zhong, Mei</au><au>Gou, Yan</au><au>Peng, Wei</au><au>Zhou, Juan</au><au>Wu, Pie</au><au>Ma, Yuying</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Development of a more specific and accurate multiple reaction monitoring method based on GC–EI/MS/MS for simultaneously monitoring and determining 34 kinds of pesticides in Qianjinzhidai pills</atitle><jtitle>Journal of chromatography. B, Analytical technologies in the biomedical and life sciences</jtitle><addtitle>J Chromatogr B Analyt Technol Biomed Life Sci</addtitle><date>2015-03-01</date><risdate>2015</risdate><volume>983-984</volume><spage>47</spage><epage>54</epage><pages>47-54</pages><issn>1570-0232</issn><eissn>1873-376X</eissn><abstract>•Thirty-four kinds of pesticides were monitored and determined by GC–EI/MS/MS.•A novel optimization method about ion transitions was provided.•This method can enhance the specificity of mass spectrum monitoring.•This method can improve the accuracy of content determination.
A rapid and accurate multi-residue method was developed for simultaneously monitoring and determining 34 kinds of pesticides by GC–EI/MS/MS, successfully applied in Qianjinzhidai pills. Precision, repeatability, stability, limit of detection (LOD), limit of quantification (LOQ), linearity range and accuracy tests were used to validate this method. The results, precision (RSD<2%, n=6), repeatability (RSD<2%, n=6) and stability (RSD<2%, n=6), LOD (lower than 0.02mg/kg), LOQ (lower than 0.067mg/kg), linearity range (0.016–39.270μg/mL), recoveries (90–110%, RSD<15%, n=6), indicated that the method was feasible. This paper provided an optimization method about ion transitions which can improve the specificity of mass spectrum monitoring and the accuracy of content determination. This method can be also used to monitor and determine pesticide residues of other traditional Chinese medicine, but it was worth noting that the ion transitions should been again optimized according to the sample matrix.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>25618250</pmid><doi>10.1016/j.jchromb.2015.01.002</doi><tpages>8</tpages></addata></record> |
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| subjects | Analytic Sample Preparation Methods Calibration Content determination Drugs, Chinese Herbal - chemistry Gas Chromatography-Mass Spectrometry - methods GC–EI/MS/MS Ion transitions Limit of Detection Linearity Monitoring Monitors Pesticide residues Pesticides Pesticides - analysis Pills Qianjinzhidai pills Reference Standards Repeatability Reproducibility Reproducibility of Results Spectrometry, Mass, Electrospray Ionization - methods Stability Traditional chinese medicine |
| title | Development of a more specific and accurate multiple reaction monitoring method based on GC–EI/MS/MS for simultaneously monitoring and determining 34 kinds of pesticides in Qianjinzhidai pills |
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